{"id":"acetaminophen-solid-formulation","safety":{"commonSideEffects":[{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Dizziness"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"featherless-qwen","explanation":"Acetaminophen's mechanism of action involves the inhibition of COX enzymes, which are responsible for the production of prostaglandins. Prostaglandins play a key role in pain and fever pathways, and their reduction leads to the therapeutic effects of acetaminophen.","oneSentence":"Acetaminophen exerts its analgesic and antipyretic effects primarily through inhibition of cyclooxygenase (COX) enzymes, leading to reduced prostaglandin synthesis.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T04:52:18.955Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Mild to moderate pain"},{"name":"Fever"}]},"trialDetails":[{"nctId":"NCT02322879","phase":"PHASE4","title":"Protective Effects of Propylene Glycol in Daily Acetaminophen Dosing","status":"COMPLETED","sponsor":"Beth Israel Deaconess Medical Center","startDate":"2013-05","conditions":"Acetaminophen Toxicity","enrollment":21},{"nctId":"NCT01246713","phase":"NA","title":"Effect on Acetaminophen Metabolism by Liquid Formulations","status":"COMPLETED","sponsor":"Beth Israel Deaconess Medical Center","startDate":"2010-12","conditions":"Acetaminophen Metabolism, Acetaminophen Poisoning, Drug Metabolism by Excipients","enrollment":15}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_1","status":"active","brandName":"Acetaminophen solid formulation","genericName":"Acetaminophen solid formulation","companyName":"Beth Israel Deaconess Medical Center","companyId":"beth-israel-deaconess-medical-center","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Acetaminophen exerts its analgesic and antipyretic effects primarily through inhibition of cyclooxygenase (COX) enzymes, leading to reduced prostaglandin synthesis. Used for Mild to moderate pain, Fever.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}