{"id":"acetaminophen-po","safety":{"commonSideEffects":[{"rate":null,"effect":"Hepatotoxicity (at high doses or chronic use)"},{"rate":null,"effect":"Rash"},{"rate":null,"effect":"Nausea"}]},"_chembl":null,"_dailymed":{"setId":"5cdb47c5-7951-4279-8a05-0a3199d3dd45","title":"JOHNSON AND JOHNSON ALL PURPOSE FIRST AID KIT (ACETAMINOPHEN, DIPHENHYDRAMINE HYDROCHLORIDE, ZINC ACETATE, NEOMYCIN SULFATE, POLYMYXIN B SULFATE, AND PRAMOXINE HYDROCHLORIDE) KIT [KENVUE BRANDS LLC]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Acetaminophen is believed to work primarily through inhibition of cyclooxygenase (COX) enzymes in the brain and spinal cord, reducing prostaglandin production and thereby lowering the pain threshold and resetting the hypothalamic thermostat. Unlike NSAIDs, it has minimal peripheral anti-inflammatory effects and does not significantly inhibit COX in peripheral tissues, which accounts for its different safety profile.","oneSentence":"Acetaminophen reduces pain and fever by inhibiting prostaglandin synthesis in the central nervous system.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:42:09.280Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Mild to moderate pain"},{"name":"Fever reduction"}]},"trialDetails":[{"nctId":"NCT06009926","phase":"PHASE2","title":"Evaluation of Broccoli Seed and Sprout Extract for Detoxification of Carcinogens in Firefighters","status":"ACTIVE_NOT_RECRUITING","sponsor":"National Cancer Institute (NCI)","startDate":"2023-12-04","conditions":"Hematopoietic and Lymphatic System Neoplasm, Malignant Solid Neoplasm, Occupational Malignant Neoplasm","enrollment":72},{"nctId":"NCT04268498","phase":"PHASE2","title":"A Study of Daratumumab, Carfilzomib, 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