{"id":"acetaminophen-plus-ibuprofen","safety":{"commonSideEffects":[{"rate":"null","effect":"Gastrointestinal upset"},{"rate":"null","effect":"Rash"},{"rate":"null","effect":"Dizziness"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Acetaminophen is a non-selective inhibitor of cyclooxygenase enzymes, which are responsible for the production of prostaglandins. Ibuprofen, on the other hand, is a selective inhibitor of COX-2, which is involved in the production of prostaglandins in the body. By inhibiting these enzymes, both drugs are able to reduce the production of prostaglandins, which in turn reduces pain and inflammation.","oneSentence":"Acetaminophen works by inhibiting the production of prostaglandins, which are chemicals that cause pain and fever, while ibuprofen works by inhibiting the enzyme COX-2, which is involved in the production of prostaglandins.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:58:57.539Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Relief of mild to moderate pain"},{"name":"Reduction of fever"}]},"trialDetails":[{"nctId":"NCT07094542","phase":"PHASE2","title":"Jaw Muscle Pain Post Wisdom Molar Surgery","status":"NOT_YET_RECRUITING","sponsor":"Rutgers, The State University of New Jersey","startDate":"2026-05","conditions":"Post Operative Pain, Impacted Third Molar Tooth, Muscle Pain","enrollment":80},{"nctId":"NCT06365892","phase":"NA","title":"Open-label Placebo (COLP) for Pain in Adolescent 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