{"id":"acetaminophen-iv-po","safety":{"commonSideEffects":[{"rate":null,"effect":"Hepatotoxicity (at high doses or chronic use)"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Rash"},{"rate":null,"effect":"Hypersensitivity reactions"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Acetaminophen is believed to work primarily through inhibition of cyclooxygenase (COX) enzymes in the brain and spinal cord, reducing prostaglandin production and thereby lowering the pain threshold and resetting the hypothalamic thermostat. The exact mechanism remains incompletely understood, but it does not significantly inhibit peripheral COX enzymes like NSAIDs do. Both intravenous and oral formulations deliver the same active compound with similar mechanisms of action, though IV administration provides faster onset.","oneSentence":"Acetaminophen reduces pain and fever by inhibiting prostaglandin synthesis in the central nervous system.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:42:01.706Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Mild to moderate pain"},{"name":"Fever reduction"}]},"trialDetails":[{"nctId":"NCT06009926","phase":"PHASE2","title":"Evaluation of Broccoli Seed and Sprout Extract for Detoxification of Carcinogens in Firefighters","status":"ACTIVE_NOT_RECRUITING","sponsor":"National Cancer Institute (NCI)","startDate":"2023-12-04","conditions":"Hematopoietic and Lymphatic System Neoplasm, Malignant Solid Neoplasm, Occupational Malignant Neoplasm","enrollment":72},{"nctId":"NCT04268498","phase":"PHASE2","title":"A Study of Daratumumab, Carfilzomib, Lenalidomide, and Dexamethasone 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