{"id":"acetaminophen-gabapentin","safety":{"commonSideEffects":[{"rate":"15-25","effect":"Dizziness"},{"rate":"10-20","effect":"Somnolence"},{"rate":"5-15","effect":"Headache"},{"rate":"5-10","effect":"Nausea"},{"rate":"<1","effect":"Hepatotoxicity (acetaminophen)"},{"rate":"5-10","effect":"Peripheral edema"}]},"_chembl":{"chemblId":"CHEMBL940","moleculeType":"Small molecule","molecularWeight":"171.24"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Acetaminophen works primarily through central inhibition of prostaglandin synthesis and modulation of descending pain pathways. Gabapentin binds to the alpha-2-delta subunit of voltage-gated calcium channels, reducing the release of excitatory neurotransmitters involved in pain transmission. Together, they provide complementary analgesic mechanisms targeting both nociceptive and neuropathic pain.","oneSentence":"This combination reduces pain through acetaminophen's central analgesic and antipyretic effects plus gabapentin's modulation of calcium channels to reduce neuropathic pain signaling.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:58:48.809Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Neuropathic pain conditions"},{"name":"Acute and chronic pain management"}]},"trialDetails":[{"nctId":"NCT03818932","phase":"PHASE2, PHASE3","title":"Nonopioid Analgesia After Anterior Cruciate Ligament Reconstruction","status":"COMPLETED","sponsor":"Henry Ford Health System","startDate":"2019-01-22","conditions":"Anterior Cruciate Ligament Injury","enrollment":90},{"nctId":"NCT06992427","phase":"PHASE3","title":"High-dose Prophylactic Gabapentin (HOPE) vs. Placebo to Prevent Opioid Use for Oral Mucositis Pain During Concurrent 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