{"id":"acetaminophen-codeine-vs-acetaminophen-oxycodone","safety":{"commonSideEffects":[{"rate":"10-25","effect":"Nausea"},{"rate":"15-30","effect":"Constipation"},{"rate":"5-15","effect":"Dizziness"},{"rate":"10-20","effect":"Drowsiness"},{"rate":"5-15","effect":"Vomiting"},{"rate":"1-5","effect":"Respiratory depression"},{"rate":null,"effect":"Dependence/tolerance"}]},"_chembl":{"chemblId":"CHEMBL1647","moleculeType":"Small molecule","molecularWeight":"327.29"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Acetaminophen works primarily through inhibition of prostaglandin synthesis in the central nervous system. Codeine and oxycodone are mu-opioid receptor agonists that modulate pain perception and emotional response to pain. The combination leverages synergistic effects: the non-opioid and opioid components work through different pathways to achieve greater analgesia than either agent alone at lower individual doses.","oneSentence":"These are combination analgesics pairing acetaminophen (a non-opioid pain reliever) with either codeine or oxycodone (opioid agonists) to provide enhanced pain relief through complementary mechanisms.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:16:56.908Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Moderate to moderately severe acute pain"},{"name":"Postoperative pain"},{"name":"Musculoskeletal pain"}]},"trialDetails":[{"nctId":"NCT05965492","phase":"PHASE3","title":"Multimodal Pain Package vs. Regular Formulation for Pain Management in Ambulatory Spinal Surgery","status":"WITHDRAWN","sponsor":"University of Miami","startDate":"2024-06-01","conditions":"Spinal Disorder","enrollment":""},{"nctId":"NCT05974501","phase":"PHASE4","title":"Pre vs Post Block in Total Knee Arthroplasty (TKA)","status":"COMPLETED","sponsor":"University of Miami","startDate":"2023-09-29","conditions":"Knee Osteoarthritis, Arthroplasty Complications, Postoperative Pain","enrollment":84},{"nctId":"NCT03820193","phase":"EARLY_PHASE1","title":"Nonopioid Analgesia After Arthroscopic Meniscus Surgery","status":"COMPLETED","sponsor":"Henry Ford Health System","startDate":"2019-01-22","conditions":"Meniscus Disorder, Narcotic Use","enrollment":61},{"nctId":"NCT05974423","phase":"PHASE4","title":"Randomized Trial of Narcotic vs Non-Narcotic Pain Modulation After Labrum Repair","status":"UNKNOWN","sponsor":"The Cooper Health System","startDate":"2022-12-16","conditions":"Postoperative Pain, Acute, Opioid Use, Labral Tear, Glenoid","enrollment":60},{"nctId":"NCT03088826","phase":"PHASE2","title":"Analgesic Efficacy of (MSIR)/Acetaminophen vs. Oxycodone/Acetaminophen (Percocet)","status":"COMPLETED","sponsor":"Antonios Likourezos","startDate":"2017-08-18","conditions":"Pain Management","enrollment":80},{"nctId":"NCT04399122","phase":"PHASE4","title":"Post-operative Pain Control After Photorefractive Keratectomy Comparing Acetaminophen/Codeine vs Acetaminophen/Oxycodone","status":"COMPLETED","sponsor":"59th Medical Wing","startDate":"2017-03-21","conditions":"Post-operative Pain Control","enrollment":200},{"nctId":"NCT04018768","phase":"","title":"Multimodal Analgesia With NSAID vs. Narcotics Alone After Shoulder Instability Surgery","status":"COMPLETED","sponsor":"NYU Langone Health","startDate":"2017-12-01","conditions":"Shoulder Pain","enrollment":80},{"nctId":"NCT03592485","phase":"PHASE4","title":"ESP vs ESP With PECS","status":"COMPLETED","sponsor":"Medical University of Lublin","startDate":"2018-06-28","conditions":"Postoperative Pain, Mitral Valve Disease","enrollment":33},{"nctId":"NCT02519023","phase":"PHASE4","title":"TAP vs Surgical Infiltration of Local Anesthetic in Laparoscopic and Robotic Hysterectomy","status":"COMPLETED","sponsor":"University of Minnesota","startDate":"2016-07","conditions":"Acute Pain","enrollment":87},{"nctId":"NCT03549611","phase":"PHASE4","title":"Pre-induction Analgesia: Multimodel Regimen vs Aceteminophen for Post Ureteroscopy Pain","status":"WITHDRAWN","sponsor":"Kevin J Flynn MD","startDate":"2018-08-01","conditions":"Kidney Calculi, Pain, Postoperative","enrollment":""},{"nctId":"NCT02862691","phase":"PHASE2","title":"Percocet vs. Bupivicaine for Toothaches in the ED","status":"TERMINATED","sponsor":"Stony Brook University","startDate":"2016-08-01","conditions":"Toothache","enrollment":2},{"nctId":"NCT02295124","phase":"PHASE4","title":"Nausea in Patients Receiving Hydromorphone vs Oxycodone After Total Hip Replacement Surgery","status":"COMPLETED","sponsor":"University Health Network, Toronto","startDate":"2012-08","conditions":"Nausea","enrollment":200}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":2,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Tylenol 3 VS Percocet"],"phase":"marketed","status":"active","brandName":"acetaminophen/codeine vs acetaminophen/oxycodone","genericName":"acetaminophen/codeine vs acetaminophen/oxycodone","companyName":"59th Medical Wing","companyId":"59th-medical-wing","modality":"Small molecule","firstApprovalDate":"","aiSummary":"These are combination analgesics pairing acetaminophen (a non-opioid pain reliever) with either codeine or oxycodone (opioid agonists) to provide enhanced pain relief through complementary mechanisms. Used for Moderate to moderately severe acute pain, Postoperative pain, Musculoskeletal pain.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}