{"id":"acetaminophen-and-ibuprofen","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal upset"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Dyspepsia"},{"rate":null,"effect":"Hepatotoxicity (acetaminophen at high doses)"},{"rate":null,"effect":"Renal impairment (ibuprofen)"}]},"_chembl":{"chemblId":"CHEMBL1647","moleculeType":"Small molecule","molecularWeight":"327.29"},"_dailymed":{"setId":"2a31a975-72f9-2a16-e063-6394a90a8149","title":"ACETAMINOPHEN 250 MG AND IBUPROFEN 125 MG (ACETAMINOPHEN 250 MG AND IBUPROFEN 125 MG TABLETS) TABLET [SUN PHARMACEUTICAL INDUSTRIES, INC.]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Acetaminophen's exact mechanism remains incompletely understood but involves inhibition of prostaglandin synthesis primarily in the CNS, affecting pain perception and temperature regulation. Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits COX-1 and COX-2 enzymes peripherally, reducing prostaglandin production and thereby decreasing inflammation, pain, and fever. The combination provides additive analgesic and antipyretic effects.","oneSentence":"Acetaminophen and ibuprofen work together to reduce pain and fever through complementary mechanisms: acetaminophen inhibits prostaglandin synthesis in the central nervous system, while ibuprofen inhibits peripheral cyclooxygenase enzymes.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:16:56.655Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Mild to moderate pain"},{"name":"Fever reduction"}]},"trialDetails":[{"nctId":"NCT07094542","phase":"PHASE2","title":"Jaw Muscle Pain Post Wisdom Molar Surgery","status":"NOT_YET_RECRUITING","sponsor":"Rutgers, The State University of New Jersey","startDate":"2026-05","conditions":"Post Operative Pain, Impacted Third Molar Tooth, Muscle Pain","enrollment":80},{"nctId":"NCT06365892","phase":"NA","title":"Open-label Placebo (COLP) for Pain in Adolescent Idiopathic Scoliosis (AIS) Surgery+Surgical Treatment of Idiopathic 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