{"id":"acetam-ketoro-tromet-group","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal upset"},{"rate":null,"effect":"Dyspepsia"},{"rate":null,"effect":"Headache"}]},"_chembl":{"chemblId":"CHEMBL2108795","moleculeType":"Vaccine component"},"_dailymed":null,"mechanism":{"_ai_source":"anthropic-haiku","explanation":"Acetaminophen inhibits prostaglandin synthesis in the central nervous system to reduce pain and fever. Ketoprofen is an NSAID that inhibits cyclooxygenase enzymes to reduce inflammation and pain. Trometamol (tromethamine) is a buffer that may enhance absorption and reduce gastrointestinal irritation from the NSAID component.","oneSentence":"This combination drug likely combines acetaminophen's analgesic and antipyretic effects with ketoprofen's nonsteroidal anti-inflammatory properties, potentially enhanced by trometamol as a buffering agent for improved tolerability.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T00:58:48.881Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute pain management (indication not fully specified in available data)"}]},"trialDetails":[{"nctId":"NCT03343392","phase":"PHASE3","title":"The Effect of Different Drugs in the Prevention of Tooth Sensitivity Caused by Tooth Bleaching Treatment.","status":"COMPLETED","sponsor":"Universidade Estadual de Ponta Grossa","startDate":"2017-11-05","conditions":"Hydrogen Peroxide Allergy","enrollment":114}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"acetam/ketoro tromet group","genericName":"acetam/ketoro tromet group","companyName":"Universidade Estadual de Ponta Grossa","companyId":"universidade-estadual-de-ponta-grossa","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This combination drug likely combines acetaminophen's analgesic and antipyretic effects with ketoprofen's nonsteroidal anti-inflammatory properties, potentially enhanced by trometamol as a buffering agent for improved tolerability. Used for Acute pain management (indication not fully specified in available data).","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}