{"id":"acei-ccb","safety":{"commonSideEffects":[{"rate":null,"effect":"Cough"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Peripheral edema"},{"rate":null,"effect":"Hypotension"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"ACE inhibitors block the conversion of angiotensin I to angiotensin II, reducing vasoconstriction and aldosterone secretion. Calcium channel blockers prevent calcium influx into vascular smooth muscle cells, causing vasodilation. Together, these complementary mechanisms provide additive antihypertensive effects with potentially improved tolerability compared to monotherapy.","oneSentence":"This combination drug blocks both angiotensin-converting enzyme (ACE) and calcium channels to reduce blood pressure through dual vasodilation and reduced vasoconstriction.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:26:10.067Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hypertension"}]},"trialDetails":[{"nctId":"NCT04040634","phase":"NA","title":"Optimal Blood Pressure for the prevenTIon of Major vAscuLar Events in Patients With DIABETES Mellitus (OPTIMAL-DIABETES)","status":"ACTIVE_NOT_RECRUITING","sponsor":"Hospital Israelita Albert Einstein","startDate":"2019-08-08","conditions":"Diabetes Mellitus, High Blood Pressure, Cardiovascular Diseases","enrollment":9476},{"nctId":"NCT04789733","phase":"NA","title":"The GUARDIAN Pilot Trial","status":"ACTIVE_NOT_RECRUITING","sponsor":"The Cleveland Clinic","startDate":"2021-04-27","conditions":"General Surgery","enrollment":80},{"nctId":"NCT07465666","phase":"","title":"A Real-world Study of the Effectiveness of Angiotensin Receptor-Neprilysin Inhibitor Therapy in Hypertensive Patients in the United Arab Emirates","status":"NOT_YET_RECRUITING","sponsor":"Novartis Pharmaceuticals","startDate":"2026-04-01","conditions":"Hypertension","enrollment":500},{"nctId":"NCT06975111","phase":"PHASE2, PHASE3","title":"Focusing on the Menopausal Transition to Improve Mid-Life Women's Health","status":"NOT_YET_RECRUITING","sponsor":"University of Colorado, Denver","startDate":"2026-03-01","conditions":"Menopause, Menopause Hot Flashes, Menopause Related Conditions","enrollment":200},{"nctId":"NCT07099677","phase":"NA","title":"Short-Term Effects of Antihypertensive Drugs on Postural Balance and Fall Risk","status":"RECRUITING","sponsor":"Abant Izzet Baysal University","startDate":"2025-08-01","conditions":"Hypertension, Fall Risk, Postural Balance","enrollment":186},{"nctId":"NCT01652209","phase":"PHASE3","title":"To Evaluate the Efficacy and Safety of Hearticelgram®-AMI in Patients With Acute Myocardial Infarction.","status":"COMPLETED","sponsor":"Pharmicell Co., Ltd.","startDate":"2013-09-01","conditions":"Acute Myocardial Infarction","enrollment":90},{"nctId":"NCT05780710","phase":"NA","title":"OBPM_Meds2023: Multicentric Prospective Clinical Study to Evaluate the Aktiia Optical Blood Pressure Monitoring (OBPM) Device Compared to Standard Home Blood Pressure Monitoring (HBPM) in Hypertensive Patients When Blood Pressure Lowering Medications Intake","status":"RECRUITING","sponsor":"Aktiia SA","startDate":"2023-06-29","conditions":"Hypertension","enrollment":35},{"nctId":"NCT06023576","phase":"PHASE2","title":"A Study of Blood Pressure Control During Cancer Treatment","status":"RECRUITING","sponsor":"Memorial Sloan Kettering Cancer Center","startDate":"2023-08-18","conditions":"Breast Cancer, Cardiotoxicity","enrollment":130},{"nctId":"NCT07262710","phase":"","title":"Association of Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers With Post-Stroke Pneumonia: A Real-World Retrospective Cohort Study","status":"NOT_YET_RECRUITING","sponsor":"First Teaching Hospital of Tianjin University of Traditional Chinese Medicine","startDate":"2025-12-01","conditions":"Post-stroke Pneumonia","enrollment":13656},{"nctId":"NCT05106036","phase":"NA","title":"Preventing Cognitive Decline by Reducing BP Target Trial","status":"RECRUITING","sponsor":"University of Texas Southwestern Medical Center","startDate":"2022-07-11","conditions":"Cognitive Decline, Blood Pressure, Hypertension","enrollment":4000},{"nctId":"NCT07110415","phase":"PHASE4","title":"Efficacy and Safety Trials of Yangxinshi Tablets in the Treatment of Patients With Coronary Heart Disease Complicated by Cardiac Dysfunction","status":"RECRUITING","sponsor":"SPH Qingdao Growful Pharmacetical Co.,Ltd","startDate":"2025-11-06","conditions":"Coronary Heart Disease, Cardiac Dysfunction","enrollment":2708},{"nctId":"NCT05049616","phase":"PHASE4","title":"Oral Combined Hydrochlorothiazide/Lisinopril Versus Oral Nifedipine for Postpartum Hypertension","status":"COMPLETED","sponsor":"The University of Texas Health Science Center, Houston","startDate":"2021-10-18","conditions":"Hypertension in Pregnancy, Postpartum Preeclampsia","enrollment":70},{"nctId":"NCT04753840","phase":"NA","title":"Long-term of Remote Ischemic Preconditioning in Patients With Mild Hypertension","status":"RECRUITING","sponsor":"Henan Institute of Cardiovascular Epidemiology","startDate":"2021-07-03","conditions":"Hypertension","enrollment":90},{"nctId":"NCT02472028","phase":"PHASE4","title":"Blood Pressure Reduction to Limit the Evolution of Vascular Brain Lesions in Elderly Individuals","status":"RECRUITING","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2015-09","conditions":"Cerebrovascular Disorders","enrollment":820},{"nctId":"NCT04884802","phase":"NA","title":"The GUARDIAN Trial","status":"RECRUITING","sponsor":"The University of Texas Health Science Center, Houston","startDate":"2021-07-25","conditions":"Blood Pressure","enrollment":6254},{"nctId":"NCT07124728","phase":"NA","title":"Syntrillo Telehealth Stroke Risk Reduction Study","status":"NOT_YET_RECRUITING","sponsor":"Syntrillo, Inc","startDate":"2025-08","conditions":"Hypertension, Hypertension (HTN), Stroke Prevention","enrollment":68},{"nctId":"NCT01679132","phase":"NA","title":"BAROSTIM NEO Hypertension Pivotal Trial","status":"SUSPENDED","sponsor":"CVRx, Inc.","startDate":"2013-04-12","conditions":"Uncontrolled Hypertension","enrollment":10},{"nctId":"NCT04864145","phase":"NA","title":"Transcatheter Self-expandable Valve Implantation for the Treatment of Severe Native Aortic Regurgitation","status":"RECRUITING","sponsor":"Nanjing First Hospital, Nanjing Medical University","startDate":"2021-05-21","conditions":"Aortic Valve Disease","enrollment":210},{"nctId":"NCT04899206","phase":"","title":"ANGIOTENSIN AGENTS AND REDUCTION OF THE PRESCRIPTION OF ANTIDEPRESSANT DRUGS: A RETROSPECTIVE COHORT STUDY USING REAL-WORLD DATA","status":"WITHDRAWN","sponsor":"Sebastian Videla","startDate":"2021-04-12","conditions":"ACE Inhibitors, ARB, Hypertension","enrollment":""},{"nctId":"NCT06964217","phase":"","title":"Immediate Fracture Risk After Antihypertensive Drug Initiation","status":"NOT_YET_RECRUITING","sponsor":"Ajou University School of Medicine","startDate":"2025-06-01","conditions":"Hypertension, Fracture","enrollment":10000000},{"nctId":"NCT01623492","phase":"","title":"Eisenmenger Quality Enhancement Research Initiative","status":"COMPLETED","sponsor":"Actelion","startDate":"2012-07-01","conditions":"Pulmonary Arterial Hypertension","enrollment":193},{"nctId":"NCT06711432","phase":"NA","title":"Different Intraoperative Blood Pressure Management on Postoperative Cognitive Function in Tumor Patients（PRECISION）","status":"RECRUITING","sponsor":"Zhejiang Cancer Hospital","startDate":"2024-09-18","conditions":"Tumor, Stroke","enrollment":214},{"nctId":"NCT06635616","phase":"","title":"Hypertension Management in Terms of Routine Agents","status":"NOT_YET_RECRUITING","sponsor":"Saglik Bilimleri Universitesi","startDate":"2024-11-01","conditions":"Hypertension, Emergency Medicine","enrollment":350},{"nctId":"NCT05169411","phase":"","title":"Preserving Kidney Function in Children With Chronic Kidney Disease","status":"COMPLETED","sponsor":"Children's Hospital of Philadelphia","startDate":"2023-09-22","conditions":"Chronic Kidney Disease Stage 2, Chronic Kidney Disease Stage 3, Pediatric Kidney Disease","enrollment":20240},{"nctId":"NCT06515678","phase":"","title":"Impact of Antihypertensive Therapy on Recurrence Risk of Ovarian Cancer for Bevacizumab-associated Hypertension","status":"ACTIVE_NOT_RECRUITING","sponsor":"Groupe Hospitalier Pitie-Salpetriere","startDate":"2024-05-20","conditions":"Ovarian Cancer, Antiangiogenic-Associated Hypertension, Adjuvant Bevacizumab","enrollment":9464},{"nctId":"NCT05122780","phase":"PHASE4","title":"Prognostic Value of Precision Medicine in Patients With MINOCA (PROMISE Trial).","status":"ACTIVE_NOT_RECRUITING","sponsor":"Fondazione Policlinico Universitario Agostino Gemelli IRCCS","startDate":"2021-07-01","conditions":"Myocardial Infarction With Non-Obstructive Coronary Arteries","enrollment":120},{"nctId":"NCT04647292","phase":"PHASE2","title":"European Blood Pressure Intensive Control After Stroke","status":"RECRUITING","sponsor":"University College Dublin","startDate":"2024-05-02","conditions":"Ischemic Stroke, Transient Ischemic Attack","enrollment":142},{"nctId":"NCT05818995","phase":"","title":"Therapeutic Drug Use for CKD Patients","status":"UNKNOWN","sponsor":"Qianfoshan Hospital","startDate":"2022-07-01","conditions":"Chronic Kidney Disease","enrollment":10000},{"nctId":"NCT01840072","phase":"NA","title":"China Antihypertensive Trial in Acute Ischemic Stroke","status":"COMPLETED","sponsor":"Tulane University","startDate":"2009-08","conditions":"Ischemic Stroke","enrollment":4071},{"nctId":"NCT01563731","phase":"PHASE4","title":"Optimal Blood Pressure and Cholesterol Targets for Preventing Recurrent Stroke in Hypertensives","status":"COMPLETED","sponsor":"Istituto Auxologico Italiano","startDate":"2013-04","conditions":"Stroke, Transient Ischemic Attack, Hypertension","enrollment":200},{"nctId":"NCT04030234","phase":"NA","title":"Effects of Intensive Systolic Blood Pressure Lowering Treatment in Reducing RIsk of Vascular evenTs (ESPRIT) Study","status":"COMPLETED","sponsor":"China National Center for Cardiovascular Diseases","startDate":"2019-09-17","conditions":"Hypertension","enrollment":11255},{"nctId":"NCT04036409","phase":"NA","title":"Optimal Blood Pressure for the prevenTIon of Major vAscuLar Events in Stroke Patients","status":"UNKNOWN","sponsor":"Hospital Israelita Albert Einstein","startDate":"2019-08-05","conditions":"Ischemic Stroke, Blood Pressure, Cognitive Impairment","enrollment":4369},{"nctId":"NCT06176599","phase":"NA","title":"Clinical Study on the Treatment of Diabetic Kidney Disease With Shenxiao Yuning Decoction With Syndrome of Qi and Yin Deficiency and Blood Stasis","status":"UNKNOWN","sponsor":"Lin Liao","startDate":"2022-09-01","conditions":"Diabetic Kidney Disease","enrollment":60},{"nctId":"NCT03479554","phase":"PHASE3","title":"China Antihypertensive Trial in Acute Ischemic Stroke II","status":"COMPLETED","sponsor":"Tulane University","startDate":"2018-06-13","conditions":"Acute Ischemic Stroke","enrollment":4810},{"nctId":"NCT05087940","phase":"","title":"Treatment of Resistant Hypertension: Cohort Study","status":"COMPLETED","sponsor":"Galenika AD Beograd","startDate":"2021-06-01","conditions":"Resistant Hypertension","enrollment":731},{"nctId":"NCT03682692","phase":"PHASE4","title":"ACEI/CCB Versus ACEI/DIU Combination Antihypertensive Therapy in Chinese Hypertensive Patients (ACvAD)","status":"COMPLETED","sponsor":"Shanghai Jiao Tong University School of Medicine","startDate":"2018-06-01","conditions":"Hypertension","enrollment":560},{"nctId":"NCT03461003","phase":"PHASE4","title":"N-of-1 Trials In Children With Hypertension","status":"COMPLETED","sponsor":"The University of Texas Health Science Center, Houston","startDate":"2018-04-02","conditions":"Pediatric Hypertension","enrollment":49},{"nctId":"NCT05470764","phase":"PHASE1","title":"Bioequivalence Study of 8 mg Perindopril Tert-Butylamine / 2.5 mg Indapamide / 10 mg Amlodipine Tablets Versus 10 mg Perindopril Arginine / 2.5 mg Indapamide / 10 mg Amlodipine Film-Coated Tablets in Healthy Volunteers","status":"COMPLETED","sponsor":"Darnitsa Pharmaceutical Company","startDate":"2021-05-30","conditions":"Bioequivalence, Healthy Subjects","enrollment":52},{"nctId":"NCT05352633","phase":"NA","title":"Effects of Intensive Systolic Blood Pressure Lowering Treatment on Out-of-office Blood Pressure - an Ancillary Study to Effects of Intensive Systolic Blood Pressure Lowering Treatment in Reducing RIsk of Vascular evenTs (ESPRIT) Study","status":"UNKNOWN","sponsor":"China National Center for Cardiovascular Diseases","startDate":"2022-07-18","conditions":"Blood Pressure","enrollment":710},{"nctId":"NCT02130687","phase":"NA","title":"Effect of Chronic ACE and DPP4 Inhibition on Blood Pressure","status":"COMPLETED","sponsor":"Vanderbilt University","startDate":"2014-06","conditions":"Type 2 Diabetes Mellitus, Hypertension","enrollment":106},{"nctId":"NCT02774460","phase":"PHASE4","title":"The Precision Hypertension Care Study","status":"COMPLETED","sponsor":"Uppsala University","startDate":"2017-02-20","conditions":"Hypertension","enrollment":280},{"nctId":"NCT03430284","phase":"PHASE4","title":"Multifactorial Intervention on Diabetes (MIDiab Study)","status":"UNKNOWN","sponsor":"Shandong Provincial Hospital","startDate":"2018-04-01","conditions":"Diabetes Mellitus, Type 2","enrollment":6300},{"nctId":"NCT03722524","phase":"","title":"The Use of TrIple Fixed-dose Combination in the Treatment of Arterial Hypertension","status":"COMPLETED","sponsor":"Servier Russia","startDate":"2018-10-01","conditions":"Arterial Hypertension","enrollment":1247},{"nctId":"NCT04191681","phase":"PHASE4","title":"Safety and Efficacy of ARNI After LVAD ImplanT (SEAL-IT) Study","status":"RECRUITING","sponsor":"The Cleveland Clinic","startDate":"2019-11-08","conditions":"Stage D Heart Failure","enrollment":50},{"nctId":"NCT04467931","phase":"","title":"ACEI or ARB and COVID-19 Severity and Mortality in US Veterans","status":"COMPLETED","sponsor":"University of Utah","startDate":"2020-01-19","conditions":"Hypertension, COVID","enrollment":22213},{"nctId":"NCT03587103","phase":"NA","title":"Learning Implementation of Guideline-based Decision Support System for Hypertension Treatment: Testing Alternative Antihypertensive Regimens Using ACE-Inhibitors, Calcium Channel Blockers and Diuretics (LIGHT-ACD)","status":"UNKNOWN","sponsor":"China National Center for Cardiovascular Diseases","startDate":"2019-08-21","conditions":"Hypertension","enrollment":5000},{"nctId":"NCT01007994","phase":"PHASE2, PHASE3","title":"Reduction of Night-time Blood Pressure in Pediatric Renal Transplant Recipients","status":"COMPLETED","sponsor":"Northwell Health","startDate":"2009-11","conditions":"Hypertension Secondary to Kidney Transplant","enrollment":33},{"nctId":"NCT01669928","phase":"PHASE4","title":"Anti-hypertensive Medication Dosing Regimen in Effective Blood Pressure Control","status":"COMPLETED","sponsor":"Imperial College London","startDate":"2012-04","conditions":"Hypertension","enrollment":103},{"nctId":"NCT04351724","phase":"PHASE2, PHASE3","title":"Austrian CoronaVirus Adaptive Clinical Trial (COVID-19)","status":"UNKNOWN","sponsor":"Medical University of Vienna","startDate":"2020-04-16","conditions":"COVID-19","enrollment":500},{"nctId":"NCT01118520","phase":"PHASE2","title":"AARDVARK (Aortic Aneurysmal Regression of Dilation: Value of ACE-Inhibition on RisK)","status":"COMPLETED","sponsor":"Imperial College London","startDate":"2011-09","conditions":"Abdominal Aortic Aneurysm","enrollment":224},{"nctId":"NCT01206062","phase":"NA","title":"Systolic Blood Pressure Intervention Trial","status":"COMPLETED","sponsor":"National Heart, Lung, and Blood Institute (NHLBI)","startDate":"2010-10","conditions":"Hypertension","enrollment":9361},{"nctId":"NCT04572724","phase":"PHASE4","title":"The Effect of Sacubitril/Valsartan on Cardiovascular Events in Dialysis Patients and Efficacy Prediction of Baseline LVEF Value","status":"UNKNOWN","sponsor":"Shenzhen Second People's Hospital","startDate":"2020-07-06","conditions":"Peritoneal Dialysis Complication, Hemodialysis Complication, Heart Failure","enrollment":120},{"nctId":"NCT04538924","phase":"NA","title":"Etiologic Mechanisms, Myocardial Changes and Prognosis of Patients With MINOCA","status":"UNKNOWN","sponsor":"Vilnius University Hospital Santaros Klinikos","startDate":"2019-01-01","conditions":"Myocardial Infarction With Nonobstructive Coronary Arteries","enrollment":150},{"nctId":"NCT04330300","phase":"PHASE4","title":"Coronavirus (COVID-19) ACEi/ARB Investigation","status":"SUSPENDED","sponsor":"National University of Ireland, Galway, Ireland","startDate":"2020-04-30","conditions":"Hypertension, COVID-19","enrollment":2414},{"nctId":"NCT04434365","phase":"PHASE1, PHASE2","title":"Effect of Berberine for Endothelial Function and Intestinal Microflora in Patients With Coronary Artery Disease","status":"UNKNOWN","sponsor":"Peking Union Medical College Hospital","startDate":"2019-06-21","conditions":"Stable Coronary Artery Disease, Percutaneous Coronary Intervention","enrollment":24},{"nctId":"NCT04379310","phase":"","title":"Evaluation of Clinical Parameters on Admission and Medications in Covid-19 Pneumonia (Corona Virus Disease 2019)","status":"COMPLETED","sponsor":"Istanbul Nisantasi University","startDate":"2020-05-01","conditions":"Covid-19","enrollment":54},{"nctId":"NCT01715376","phase":"","title":"Effects of Integrated Treatment by Traditional Chinese and Western Medicine in Reducing Cardiovascular Events","status":"COMPLETED","sponsor":"Changchun University of Chinese Medicine","startDate":"2012-03","conditions":"Angina Pectoris, Coronary Artery Disease, Coronary Disease","enrollment":1042},{"nctId":"NCT04364139","phase":"PHASE3","title":"African American Study of Kidney Disease and Hypertension","status":"COMPLETED","sponsor":"National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)","startDate":"1995-02-01","conditions":"Hypertensive Nephrosclerosis, Chronic Renal Insufficiency","enrollment":1094},{"nctId":"NCT04364113","phase":"PHASE3","title":"The Modification of Diet in Renal Disease Study","status":"COMPLETED","sponsor":"National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)","startDate":"1989-01-01","conditions":"Chronic Renal Disease","enrollment":840},{"nctId":"NCT00283686","phase":"PHASE3","title":"HALT Progression of Polycystic Kidney Disease Study A","status":"COMPLETED","sponsor":"National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)","startDate":"2006-01","conditions":"Kidney, Polycystic","enrollment":558},{"nctId":"NCT03747978","phase":"PHASE4","title":"Short-term Effects of Perindopril-amlodipine Versus Perindopril-indapamide in Type 2 Diabetes","status":"COMPLETED","sponsor":"Yaounde Central Hospital","startDate":"2016-10-01","conditions":"Diabetes Mellitus, Type 2, Hypertension","enrollment":30},{"nctId":"NCT02412761","phase":"NA","title":"Series of N-of-1 Crossover Trials of Antihypertensive Therapy in Adolescents With Essential Hypertension","status":"COMPLETED","sponsor":"The University of Texas Health Science Center, Houston","startDate":"2013-06","conditions":"Essential Hypertension","enrollment":42},{"nctId":"NCT00430638","phase":"PHASE4","title":"A Study of the Blood Pressure Lowering Ability and Safety of Olmesartan Medoxomil in Stage I and Stage II Hypertension","status":"COMPLETED","sponsor":"Daiichi Sankyo","startDate":"2006-12","conditions":"Hypertension","enrollment":278},{"nctId":"NCT02390193","phase":"NA","title":"Effect of Hemodialysis on Upper Airways Collapsibility in Patients With Chronic Kidney Disease","status":"UNKNOWN","sponsor":"Centro Universitário de Anapolis","startDate":"2015-01-02","conditions":"Renal Insufficiency, Chronic","enrollment":52},{"nctId":"NCT02298556","phase":"","title":"An Observational Study to Describe the Effectiveness of Angiotensin Converting Enzyme Inhibitor and Calcium Channel Blocker Combination in the Management of Hypertensive Patients With Elevated Heart Rate and Type 2 Diabetes","status":"COMPLETED","sponsor":"Abbott","startDate":"2014-10","conditions":"Hypertension","enrollment":270},{"nctId":"NCT02967484","phase":"NA","title":"Acupuncture Lowering Blood Pressure for Secondary Prevention of Stroke","status":"UNKNOWN","sponsor":"First Teaching Hospital of Tianjin University of Traditional Chinese Medicine","startDate":"2016-11-20","conditions":"Cerebral Infarction","enrollment":480},{"nctId":"NCT02425969","phase":"NA","title":"A Trial in Stable Intermediate Coronary Lesions and Grey-zone FFR Values","status":"COMPLETED","sponsor":"Golden Jubilee National Hospital","startDate":"2015-04","conditions":"Grey-zone Fractional Flow Reserve, Intermediate Coronary Lesions, Stable Angina","enrollment":108},{"nctId":"NCT01994408","phase":"PHASE1, PHASE2","title":"Default BP Medication Intensification","status":"TERMINATED","sponsor":"Cedars-Sinai Medical Center","startDate":"2013-11","conditions":"Hypertension","enrollment":3},{"nctId":"NCT02995954","phase":"PHASE4","title":"Fixed vs Free Dose of ACEi/CCB Combination Therapy","status":"COMPLETED","sponsor":"Guido Iaccarino","startDate":"2014-01","conditions":"Hypertension","enrollment":100},{"nctId":"NCT00403481","phase":"PHASE4","title":"An Examination of the Blood Pressure Lowering Ability and Safety of Olmesartan Medoxomil in Patients With Type II Diabetes","status":"COMPLETED","sponsor":"Daiichi Sankyo","startDate":"2006-11","conditions":"Hypertension","enrollment":192},{"nctId":"NCT01167920","phase":"NA","title":"Virtual Hypertension Clinic","status":"COMPLETED","sponsor":"The Cleveland Clinic","startDate":"2009-11","conditions":"Hypertension","enrollment":74},{"nctId":"NCT00006305","phase":"PHASE3","title":"Bypass Angioplasty Revascularization Investigation in Type 2 Diabetes","status":"COMPLETED","sponsor":"University of Pittsburgh","startDate":"2000-09","conditions":"Coronary Disease, Cardiovascular Diseases, Heart Diseases","enrollment":2368},{"nctId":"NCT02646397","phase":"PHASE4","title":"Benidipine and Hydrochlorothiazide in Fosinopril Treated Chronic Kidney Disease Patients With Hypertension","status":"UNKNOWN","sponsor":"Shanghai Changzheng Hospital","startDate":"2016-02","conditions":"Chronic Kidney Disease","enrollment":508},{"nctId":"NCT01819441","phase":"PHASE4","title":"Stratification of Blood Pressure Control Against Progress of Cerebral Small Vessel Diseases in Poststroke Patients","status":"UNKNOWN","sponsor":"Yining Huang","startDate":"2012-05","conditions":"Cerebral Small Vessel Diseases","enrollment":1200},{"nctId":"NCT01089452","phase":"PHASE4","title":"Angiotensin Receptor Blocker Combined With Calcium Antagonist Evaluation of Safety and Lowering of Systolic Blood Pressure Study","status":"WITHDRAWN","sponsor":"Monash University","startDate":"","conditions":"Hypertension","enrollment":""},{"nctId":"NCT00721773","phase":"NA","title":"Renal Protective Effects of Renin Angiotensin System (RAS) Inhibitor in Peritoneal Dialysis Patients","status":"COMPLETED","sponsor":"Sun Yat-sen University","startDate":"2008-09","conditions":"Renal Function Disorder","enrollment":200},{"nctId":"NCT00190580","phase":"PHASE4","title":"Kanagawa Valsartan Trial (KVT): Effects of Valsartan on Renal and Cardiovascular Disease","status":"COMPLETED","sponsor":"KVT-Study Group","startDate":"2003-02","conditions":"Chronic Kidney Disease, Hypertension","enrollment":312},{"nctId":"NCT02248896","phase":"","title":"Antihypertensive Medications and the Risk of Sepsis","status":"COMPLETED","sponsor":"Boehringer Ingelheim","startDate":"2010-01","conditions":"Hypertension","enrollment":1129062},{"nctId":"NCT00178490","phase":"PHASE1","title":"Effect of High Blood Pressure and Antihypertensive Treatment on Brain Functioning in Children","status":"COMPLETED","sponsor":"University of Rochester","startDate":"2005-01","conditions":"Hypertension","enrollment":100},{"nctId":"NCT01631409","phase":"","title":"Estimation of the Long Term Effectiveness of Routine Use of Cardiac Shock Wave Therapy","status":"WITHDRAWN","sponsor":"City Hospital No 40, Saint Petersburg, Russia","startDate":"2013-09","conditions":"Coronary Heart Disease (CHD)","enrollment":""},{"nctId":"NCT01380717","phase":"PHASE4","title":"Renal and Systemic Vascular Resistance in Chronic Kidney Disease (CKD)","status":"COMPLETED","sponsor":"University of Aarhus","startDate":"2011-02","conditions":"Chronic Kidney Insufficiency, Hypertension, Vasodilation","enrollment":83},{"nctId":"NCT00742274","phase":"NA","title":"A European Study on Medical Management Versus TAG Device + Medical Management for Acute Uncomplicated Type B Dissection","status":"COMPLETED","sponsor":"W.L.Gore & Associates","startDate":"2008-08","conditions":"Aortic Diseases","enrollment":61},{"nctId":"NCT01829126","phase":"","title":"Development and Prevention of Severe Heart Disease in Systemic Sclerosis","status":"UNKNOWN","sponsor":"Gabriele Valentini","startDate":"2013-04","conditions":"Systemic Sclerosis, Cardiac Diseases, Heart Block","enrollment":765},{"nctId":"NCT01974544","phase":"NA","title":"Prevention and Treatment Of Diabetes Complications With Gastric Surgery or Intensive Medicines","status":"UNKNOWN","sponsor":"Pontificia Universidad Catolica de Chile","startDate":"2013-05","conditions":"Type 2 Diabetes","enrollment":150},{"nctId":"NCT01101503","phase":"PHASE2","title":"The Effect of Intensive Multifactorial Therapy on Endothelial Function in Newly Diagnosed Type 2 Diabetes","status":"UNKNOWN","sponsor":"Xiang Guang-da","startDate":"2010-04","conditions":"Endothelial Dysfunction","enrollment":1000},{"nctId":"NCT01713270","phase":"NA","title":"Renal Sympathetic Denervation in Patients With Drug-resistant Hypertension and Symptomatic Atrial Fibrillation","status":"UNKNOWN","sponsor":"The First Affiliated Hospital with Nanjing Medical University","startDate":"2012-07","conditions":"Hypertension, Atrial Fibrillation","enrollment":200},{"nctId":"NCT00129233","phase":"PHASE4","title":"Comparison of Valsartan With Amlodipine in Hypertensive Patients With Glucose Intolerance","status":"COMPLETED","sponsor":"Nagoya University","startDate":"2004-10","conditions":"Hypertension, Type 2 Diabetes Mellitus","enrollment":1150},{"nctId":"NCT01173029","phase":"","title":"Renin-angiotensin-aldosterone System Polymorphisms in Resistant Hypertension and Adverse Cardiovascular Events","status":"COMPLETED","sponsor":"Universidade Gama Filho","startDate":"2001-06","conditions":"Systemic Arterial Hypertension, Hypertension Resistant to Conventional Therapy, Myocardial Infarction","enrollment":92},{"nctId":"NCT01737138","phase":"NA","title":"Renal Sympathetic Denervation in Patients With Chronic Kidney Disease and Resistant Hypertension","status":"UNKNOWN","sponsor":"The First Affiliated Hospital with Nanjing Medical University","startDate":"2012-11","conditions":"Chronic Kidney Disease","enrollment":100},{"nctId":"NCT01403922","phase":"PHASE1","title":"To Determine Blood Pressure Interaction Between TC-5214 and Anti-Hypertensive Medications (Calcium Channel Blockers, Beta Blockers, and ACE Inhibitors) in Patients With Chronic Hypertension","status":"TERMINATED","sponsor":"AstraZeneca","startDate":"2011-08","conditions":"Chronic Hypertension","enrollment":80},{"nctId":"NCT00637078","phase":"PHASE4","title":"STITCH2 (Simplified Therapeutic Intervention to Control Hypertension and Hypercholesterolemia)","status":"COMPLETED","sponsor":"University of Western Ontario, Canada","startDate":"2008-02","conditions":"Hypertension, Hypercholesterolemia","enrollment":1000},{"nctId":"NCT01560806","phase":"NA","title":"Intervention Study on Hypertension Management Combined With Health Promotion at Commune Level","status":"COMPLETED","sponsor":"Vietnam National Heart Institute","startDate":"2006-12","conditions":"Hypertension, Cardiovascular Risk Factor, Lifestyle","enrollment":2400},{"nctId":"NCT00185120","phase":"PHASE4","title":"Treatment of High Blood Pressure Using Olmesartan With Hydrochlorothiazide Compared to an ACE Inhibitor With a Calcium Channel Blocker","status":"COMPLETED","sponsor":"Daiichi Sankyo","startDate":"2005-09","conditions":"Hypertension","enrollment":152},{"nctId":"NCT01508663","phase":"PHASE4","title":"The Beneficial Role of Percutaneous Coronary Intervention Over Optimal Medical Therapy in Elderly Patients With Coronary Artery Disease","status":"UNKNOWN","sponsor":"Yonsei University","startDate":"2010-08","conditions":"Coronary Artery Disease","enrollment":1600},{"nctId":"NCT01411371","phase":"NA","title":"Catheter Ablation Versus Medical Treatment of AF in Heart Failure","status":"UNKNOWN","sponsor":"Barts & The London NHS Trust","startDate":"2005-03","conditions":"Atrial Fibrillation, Heart Failure","enrollment":60},{"nctId":"NCT00408512","phase":"PHASE4","title":"Pharmacosurveillance and Pharmacogenetics of First-line Diuretics in Hypertension: The StayOnDiur Study","status":"COMPLETED","sponsor":"Federico II University","startDate":"2006-12","conditions":"Essential Hypertension","enrollment":2500},{"nctId":"NCT01041963","phase":"PHASE4","title":"The Effect of Enalapril and Losartan on Peritoneal Membrane in Continuous Ambulatory Peritoneal Dialysis Patients","status":"UNKNOWN","sponsor":"Chulalongkorn University","startDate":"2009-06","conditions":"Continuous Ambulatory Peritoneal Dialysis","enrollment":90},{"nctId":"NCT00890279","phase":"PHASE2","title":"Efficacy and Safety Study of Second-Line Treatment for Hypertension With Autosomal Dominant Polycystic Kidney Disease(ADPKD)","status":"UNKNOWN","sponsor":"Ministry of Health, Labour and Welfare, Japan","startDate":"2009-07","conditions":"Kidney, Polycystic, Autosomal Dominant","enrollment":160},{"nctId":"NCT00412932","phase":"PHASE4","title":"An Examination of the Blood Pressure Lowering Ability and Safety of Olmesartan Medoxomil in Elderly Patients With Hypertension","status":"COMPLETED","sponsor":"Daiichi Sankyo","startDate":"2006-12","conditions":"Hypertension","enrollment":178},{"nctId":"NCT00541853","phase":"PHASE4","title":"CCB Safety Study in Treatment of Hypertension of ADPKD","status":"UNKNOWN","sponsor":"Kyorin University","startDate":"2007-12","conditions":"Kidney, Polycystic, Autosomal Dominant","enrollment":150}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":35,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"ACEI/CCB","genericName":"ACEI/CCB","companyName":"Shanghai Jiao Tong University School of Medicine","companyId":"shanghai-jiao-tong-university-school-of-medicine","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This combination therapy simultaneously blocks angiotensin II formation (via ACE inhibition) and calcium channels to reduce blood pressure through complementary vasodilatory pathways. Used for Hypertension.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}