{"id":"acedapsone","rwe":[{"pmid":"37907954","year":"2023","title":"The pipeline for drugs for control and elimination of neglected tropical diseases: 2. Oral anti-infective drugs and drug combinations for off-label use.","finding":"","journal":"Parasites & vectors","studyType":"Clinical Study"},{"pmid":"33117053","year":"2020","title":"The State of Affairs in Post-Exposure Leprosy Prevention: A Descriptive Meta-Analysis on Immuno- and Chemo-Prophylaxis.","finding":"","journal":"Research and reports in tropical medicine","studyType":"Clinical Study"},{"pmid":"32339493","year":"2020","title":"Metabolism and interactions of antileprosy drugs.","finding":"","journal":"Biochemical pharmacology","studyType":"Clinical Study"},{"pmid":"20107683","year":"2009","title":"Chemoprophylaxis in contacts of patients with leprosy: systematic review and meta-analysis.","finding":"","journal":"Revista panamericana de salud publica = Pan American journal of public health","studyType":"Clinical Study"},{"pmid":"12862255","year":"2003","title":"Effectiveness of multidrug therapy in multibacillary leprosy: a long-term follow-up of 34 multibacillary leprosy patients treated with multidrug regimens till skin smear negativity.","finding":"","journal":"Leprosy review","studyType":"Clinical Study"}],"tags":[{"label":"acedapsone","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"},{"label":"Anti-Bacterial Agents","category":"pharmacology"},{"label":"Anti-Infective Agents","category":"pharmacology"},{"label":"Antimalarials","category":"pharmacology"},{"label":"Antiparasitic Agents","category":"pharmacology"},{"label":"Antiprotozoal Agents","category":"pharmacology"},{"label":"Leprostatic Agents","category":"pharmacology"}],"phase":"phase_2","safety":{"commonSideEffects":[]},"trials":["NCT00520442"],"aliases":[],"patents":[],"pricing":[],"allNames":"acetamin","offLabel":[],"synonyms":["acedapsone","acetamin","diacetyldapsone","sulfadiamine","sulfodiamin","sulfodiamine"],"timeline":[],"brandName":"Acetamin","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"acedapsone","explanation":"Think of it like a roadblock in a factory. Acedapsone blocks the production of a key component, folic acid, which is necessary for certain bacteria to grow and multiply. By stopping this process, acedapsone can help prevent the spread of infections.","oneSentence":"Acedapsone works by inhibiting the enzyme dihydropteroate synthase, which is involved in the synthesis of folic acid.","technicalDetail":"Acedapsone exerts its antibacterial effects by competitively inhibiting dihydropteroate synthase, an enzyme essential for the de novo synthesis of tetrahydrofolate, a critical cofactor in bacterial metabolism."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3662","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=ACEDAPSONE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T08:21:43.661319","biosimilars":[],"competitors":[],"dataSources":[{"url":"https://clinicaltrials.gov","name":"ClinicalTrials.gov","fields":["trialDetails","trials"],"retrievedDate":"2026-04-07"},{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"acedapsone","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[{"nctId":"NCT00520442","phase":"NA","title":"Ibuprofen Versus Acetaminophen With Codeine In Acute Pediatric Forearm Fractures","status":"COMPLETED","sponsor":"Medical College of Wisconsin","isPivotal":false,"enrollment":335,"indication":"Fracture","completionDate":"2007-09"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"UNII":"0GZ72U84TN","CHEBI":"CHEBI:139474","INN_ID":"2719","UMLSCUI":"C0000949","ChEMBL_ID":"CHEMBL154166","KEGG_DRUG":"D02751","PUBCHEM_CID":"6477","MESH_DESCRIPTOR_UI":"D000072"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":33,"therapeuticAreas":["Metabolic"],"biosimilarFilings":[],"recentPublications":[{"date":"2023 Oct 31","pmid":"37907954","title":"The pipeline for drugs for control and elimination of neglected tropical diseases: 2. Oral anti-infective drugs and drug combinations for off-label use.","journal":"Parasites & vectors"},{"date":"2020","pmid":"33117053","title":"The State of Affairs in Post-Exposure Leprosy Prevention: A Descriptive Meta-Analysis on Immuno- and Chemo-Prophylaxis.","journal":"Research and reports in tropical medicine"},{"date":"2020 Jul","pmid":"32339493","title":"Metabolism and interactions of antileprosy drugs.","journal":"Biochemical pharmacology"},{"date":"2009 Oct","pmid":"20107683","title":"Chemoprophylaxis in contacts of patients with leprosy: systematic review and meta-analysis.","journal":"Revista panamericana de salud publica = Pan American journal of public health"},{"date":"2003 Jun","pmid":"12862255","title":"Effectiveness of multidrug therapy in multibacillary leprosy: a long-term follow-up of 34 multibacillary leprosy patients treated with multidrug regimens till skin smear negativity.","journal":"Leprosy review"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Acedapsone, also known as Acetamin, is a small molecule drug in the acedapsone class. Its original development is attributed to an unknown entity, and its current ownership is also unclear. The exact target of acedapsone is unknown, and it has not been approved by the FDA for any indications. As a result, there is limited information available on its commercial status, pharmacokinetics, or safety profile. Further research is needed to fully understand acedapsone's properties and potential applications.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":true,"score":2}}