{"id":"aceclofenac-and-esomeprazole","safety":{"commonSideEffects":[{"rate":"10%","effect":"Diarrhea"},{"rate":"8%","effect":"Nausea"},{"rate":"6%","effect":"Abdominal pain"},{"rate":"5%","effect":"Headache"},{"rate":"4%","effect":"Dizziness"}]},"_chembl":{"chemblId":"CHEMBL93645","moleculeType":"Small molecule","molecularWeight":"354.19"},"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Aceclofenac is a nonsteroidal anti-inflammatory drug (NSAID) that works by inhibiting the enzyme cyclooxygenase-2 (COX-2), which is responsible for the production of prostaglandins. Prostaglandins are chemical messengers that cause pain, inflammation, and fever. By inhibiting COX-2, aceclofenac reduces the production of prostaglandins, thereby reducing pain and inflammation. Esomeprazole, on the other hand, is a proton pump inhibitor (PPI) that works by blocking the action of the enzyme H+/K+ ATPase in the stomach lining, which is responsible for the production of stomach acid. By blocking this enzyme, esomeprazole reduces the production of stomach acid, thereby reducing symptoms of gastroesophageal reflux disease (GERD) and other acid-related disorders.","oneSentence":"Inhibits COX-2 and blocks the action of prostaglandins, thereby reducing inflammation and pain, and also inhibits the proton pump in the stomach, thereby reducing acid production.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T04:52:14.055Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Gastroesophageal reflux disease (GERD)"},{"name":"Peptic ulcer disease"}]},"trialDetails":[{"nctId":"NCT03127046","phase":"PHASE1","title":"Drug-drug Interaction Between Aceclofenac 200 mg and Esomeprazole 20 mg in Healthy Male Volunteers","status":"UNKNOWN","sponsor":"Dong Wha Pharmaceutical Co. Ltd.","startDate":"2017-03-31","conditions":"Healthy","enrollment":30}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Airtal and Nexium concomitant"],"phase":"phase_1","status":"active","brandName":"Aceclofenac and Esomeprazole","genericName":"Aceclofenac and Esomeprazole","companyName":"Dong Wha Pharmaceutical Co. Ltd.","companyId":"dong-wha-pharmaceutical-co-ltd","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Inhibits COX-2 and blocks the action of prostaglandins, thereby reducing inflammation and pain, and also inhibits the proton pump in the stomach, thereby reducing acid production. Used for Gastroesophageal reflux disease (GERD), Peptic ulcer disease.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}