{"id":"acecarbromal","rwe":[{"pmid":"2079506","year":"1990","title":"Identification and differentiation of barbiturates, other sedative-hypnotics and their metabolites in urine integrated in a general screening procedure using computerized gas chromatography-mass spectrometry.","finding":"","journal":"Journal of chromatography","studyType":"Clinical Study"},{"pmid":"20869","year":"1977","title":"Separation and quantitative determination of acecarbromal, carbromal, and bromisoval as well as their main metabolites by means of high-pressure liquid chromatographic analysis.","finding":"","journal":"Archives of toxicology","studyType":"Clinical Study"}],"tags":[{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"},{"label":"Central Nervous System Agents","category":"pharmacology"},{"label":"Central Nervous System Depressants","category":"pharmacology"},{"label":"Hypnotics and Sedatives","category":"pharmacology"}],"phase":"phase_2","safety":{"commonSideEffects":[]},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"paxarel","offLabel":[],"synonyms":["acecarbromal","acetcarbromal","acetylcarbromal","paxarel"],"timeline":[],"brandName":"Paxarel","ecosystem":[],"mechanism":{"modality":"Small Molecule","explanation":"In simple terms, Paxarel is believed to affect the way that brain cells communicate with each other, which can help to reduce anxiety and promote relaxation. This is achieved by influencing the levels and activity of chemicals called neurotransmitters, such as GABA and glutamate, which play a crucial role in regulating mood and emotional responses.","oneSentence":"Paxarel is thought to work by modulating the activity of certain neurotransmitters in the brain.","technicalDetail":"The exact mechanism of action of Paxarel is not well-characterized, but it is thought to involve the modulation of GABA_A receptors and the inhibition of glutamate release, leading to a decrease in excitatory neurotransmission and an increase in inhibitory neurotransmission."},"_wikipedia":{"url":"https://en.wikipedia.org/wiki/Acecarbromal","title":"Acecarbromal","extract":"Acecarbromal (INN), also known as acetylcarbromal and acetyladalin, is a hypnotic and sedative drug of the ureide (acylurea) group discovered by Bayer in 1917 that was formerly marketed in the United States and Europe. It is also used in combination with extract of quebracho and vitamin E as a treatment for erectile dysfunction under the brand name Afrodor in Europe. Acecarbromal is structurally related to the barbiturates, which are basically cyclized ureas. Prolonged use is not recommended as it can cause bromine poisoning."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/42","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=ACECARBROMAL","fields":["publications"],"source":"PubMed/NCBI"},{"id":3,"url":"https://en.wikipedia.org/wiki/Acecarbromal","fields":["history","overview"],"source":"Wikipedia"}],"_enrichedAt":"2026-03-30T08:21:29.328823","biosimilars":[],"competitors":[],"genericName":"acecarbromal","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NUI":"N0000179026","MMSL":"4125","NDDF":"007110","UNII":"E47C56IGOY","VUID":"4019029","CHEBI":"CHEBI:135155","VANDF":"4019029","INN_ID":"1549","RXNORM":"16688","UMLSCUI":"C0050402","ChEMBL_ID":"CHEMBL2104673","KEGG_DRUG":"D07059","PUBCHEM_CID":"6489","SNOMEDCT_US":"108389007","MESH_SUPPLEMENTAL_RECORD_UI":"C023718"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":2,"therapeuticAreas":["Neuroscience"],"biosimilarFilings":[],"recentPublications":[{"date":"1990 Sep 14","pmid":"2079506","title":"Identification and differentiation of barbiturates, other sedative-hypnotics and their metabolites in urine integrated in a general screening procedure using computerized gas chromatography-mass spectrometry.","journal":"Journal of chromatography"},{"date":"1977 Aug 9","pmid":"20869","title":"Separation and quantitative determination of acecarbromal, carbromal, and bromisoval as well as their main metabolites by means of high-pressure liquid chromatographic analysis.","journal":"Archives of toxicology"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Paxarel is a small molecule. It is also known by the synonyms ABASIN, ACECARBROMAL, and SEDAMYL.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}