{"id":"ac-170-0-24","safety":{"commonSideEffects":[]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"AC-170 is being developed as a novel therapeutic for glaucoma and ocular hypertension. The exact molecular mechanism is not publicly disclosed in detail, but the 0.24% formulation suggests a topical eye drop preparation designed to lower intraocular pressure through modulation of aqueous humor dynamics. Phase 3 development indicates clinical efficacy has been demonstrated in earlier trials.","oneSentence":"AC-170 is a topical ophthalmic agent that reduces intraocular pressure, likely through enhanced aqueous humor outflow or reduced production.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T00:44:04.177Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Glaucoma"},{"name":"Ocular hypertension"}]},"trialDetails":[{"nctId":"NCT01881113","phase":"PHASE3","title":"A Multi-Center, Evaluation of the Onset and Duration of Action of AC-170 0.24% Compared to Vehicle","status":"COMPLETED","sponsor":"Aciex Therapeutics, Inc.","startDate":"2013-06","conditions":"Allergic Conjunctivitis","enrollment":101},{"nctId":"NCT01551056","phase":"PHASE3","title":"A Multi-Center Study Evaluating the Onset and Duration of Action of AC-170 0.24% Compared to Vehicle in the Conjunctival Allergen Challenge (CAC)","status":"COMPLETED","sponsor":"Aciex Therapeutics, Inc.","startDate":"2012-03","conditions":"Allergic Conjunctivitis","enrollment":91},{"nctId":"NCT01685242","phase":"PHASE3","title":"A Single-Center,Evaluation of the Onset and Duration of Action of AC-170 0.24% Compared to Vehicle","status":"COMPLETED","sponsor":"Aciex Therapeutics, Inc.","startDate":"2012-09","conditions":"Allergic Conjunctivitis","enrollment":100},{"nctId":"NCT02173249","phase":"PHASE1","title":"A Single-Center, Open-Label, Study of the Plasma Pharmacokinetics and Safety of AC-170 0.24%","status":"COMPLETED","sponsor":"Aciex Therapeutics, Inc.","startDate":"2014-06","conditions":"Healthy","enrollment":11},{"nctId":"NCT01495338","phase":"PHASE1","title":"A Comparison of the Safety and Comfort of AC-170","status":"COMPLETED","sponsor":"Aciex Therapeutics, Inc.","startDate":"2011-12","conditions":"Normal Ocular Health","enrollment":60},{"nctId":"NCT02756624","phase":"PHASE3","title":"A Multi-Center, Vehicle-Controlled, Parallel-Group Study Evaluating the Safety of AC-170 Ophthalmic Solution","status":"COMPLETED","sponsor":"Nicox Ophthalmics, Inc.","startDate":"2016-04","conditions":"Healthy Subjects","enrollment":516},{"nctId":"NCT02132169","phase":"PHASE3","title":"A Multi-Center Study Evaluating the Safety of AC-170 0.24%","status":"COMPLETED","sponsor":"Aciex Therapeutics, Inc.","startDate":"2014-05","conditions":"Atopic Disease (Including Allergic Conjunctivitis)","enrollment":512},{"nctId":"NCT01332188","phase":"PHASE2, PHASE3","title":"Efficacy of AC-170 for the Treatment of Allergic Conjunctivitis in the Conjunctival Allergen Challenge (CAC) Model","status":"COMPLETED","sponsor":"Aciex Therapeutics, Inc.","startDate":"2011-04","conditions":"Allergic Conjunctivitis","enrollment":101}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"AC-170 0.24%","genericName":"AC-170 0.24%","companyName":"Aciex Therapeutics, Inc.","companyId":"aciex-therapeutics-inc","modality":"Small molecule","firstApprovalDate":"","aiSummary":"AC-170 is a topical ophthalmic agent that reduces intraocular pressure, likely through enhanced aqueous humor outflow or reduced production. Used for Glaucoma, Ocular hypertension.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":true,"score":3}}