{"id":"abrocitinib-suspension-f6","rwe":[],"tags":[],"safety":{"drugInteractions":[{"drug":"Warfarin","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Live vaccines","action":"Avoid","effect":"Decreased vaccine efficacy"},{"drug":"Bacillus Calmette-Guérin (BCG) vaccine","action":"Avoid","effect":"Decreased vaccine efficacy"},{"drug":"Other vaccines","action":"Avoid","effect":"Decreased vaccine efficacy"},{"drug":"Interleukin-1 (IL-1) inhibitors","action":"Monitor","effect":"Increased risk of infections"},{"drug":"Live attenuated influenza vaccine","action":"Avoid","effect":"Decreased vaccine efficacy"},{"drug":"Tuberculosis vaccine","action":"Avoid","effect":"Decreased vaccine efficacy"},{"drug":"Vaccines","action":"Avoid","effect":"Decreased vaccine efficacy"},{"drug":"Vaccines (live)","action":"Avoid","effect":"Decreased vaccine efficacy"},{"drug":"Vaccines (live, attenuated)","action":"Avoid","effect":"Decreased vaccine efficacy"},{"drug":"Vaccines (live, attenuated, or inactivated)","action":"Avoid","effect":"Decreased vaccine efficacy"},{"drug":"Vaccines (live, attenuated, or inactivated; 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including inactivated influenza vaccine and MMR vaccine; and other vaccines; and BCG vaccine; and oral poliovirus vaccine; and rotavirus vaccine; and yellow fever vaccine; and varicella vaccine; and zoster vaccine; and HPV vaccine; and meningococcal conjugate vaccine; and pneumococcal conjugate vaccine; and Hib vaccine; and DTaP vaccine; and Tdap vaccine; and MMR vaccine; and inactivated influenza vaccine; and oral poliovirus vaccine; and rotavirus vaccine; and yellow fever vaccine; and varicella vaccine)","action":"Avoid","effect":"Decreased vaccine efficacy"},{"drug":"Vaccines (live, attenuated, or inactivated; including inactivated influenza vaccine and MMR vaccine; and other vaccines; and BCG vaccine; and oral poliovirus vaccine; and rotavirus vaccine; and yellow fever vaccine; and varicella vaccine; and zoster vaccine; and HPV vaccine; and meningococcal conjugate vaccine; and pneumococcal conjugate vaccine; and Hib vaccine; and DTaP vaccine; and Tdap vaccine; and MMR vaccine; and inactivated influenza vaccine; 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and rotavirus vaccine; and yellow fever vaccine; and varicella vaccine; and zoster vaccine; and HPV vaccine; and meningococcal conjugate vaccine; and pneumococcal conjugate vaccine; and Hib vaccine; and DTaP vaccine; and Tdap vaccine; and MMR vaccine; and inactivated influenza vaccine; and oral poliovirus vaccine; and rotavirus vaccine; and yellow fever vaccine; and varicella vaccine; and zoster vaccine; and HPV vaccine; and meningococcal conjugate vaccine)","action":"Avoid","effect":"Decreased vaccine efficacy"},{"drug":"Vaccines (live, attenuated, or inactivated; including inactivated influenza vaccine and MMR vaccine; and other vaccines; and BCG vaccine; and oral poliovirus vaccine; and rotavirus vaccine; and yellow fever vaccine; and varicella vaccine; and zoster vaccine; and HPV vaccine; and meningococcal conjugate vaccine; and pneumococcal conjugate vaccine; and Hib vaccine; and DTaP vaccine; and Tdap vaccine; and MMR vaccine; and inactivated influenza vaccine; and oral poliovirus vaccine; and rotavirus vaccine; and yellow fever vaccine; and varicella vaccine; and zoster vaccine; and HPV vaccine; and meningococcal conjugate vaccine; and pneumococcal conjugate vaccine)","action":"Avoid","effect":"Decreased vaccine efficacy"}],"commonSideEffects":[],"contraindications":["Do not start CIBINQO if you: - are under 12 years of age\n- intend to use it for a condition for which it was not prescribed \n- have any kind of infection unless your healthcare provider tells you it is okay \n- have any signs and symptoms of blood clots \n- have lymphocyte, neutrophil, red blood cell, or platelet counts that are too low \n- take medicines that prevent blood clots (antiplatelet medicines), except for low-dose aspirin up to a dose of 81 mg each day during the first 3 months of CIBINQO treatment \n- are taking certain other medicines\n- are breastfeeding or plan to breastfeed\n- have severe kidney problems\n- have severe liver problems\n- recently received a live vaccine"],"specialPopulations":{"Pregnancy":"Pregnancy Exposure Registry There is a pregnancy exposure registry that monitors pregnancy outcomes in women exposed to CIBINQO during pregnancy. Pregnant women exposed to CIBINQO and health care providers are encouraged to call 1-877-311-3770. Risk Summary  Based on the findings in rats, oral administration of CIBINQO may impair female fertility. Impaired fertility in female rats was reversible 1 month after cessation of abrocitinib oral administration [see Nonclinical Toxicology (13.1)].","Geriatric use":"The safety and effectiveness of CIBINQO have not been established in patients 65 years of age and older.","Paediatric use":"The safety and effectiveness of CIBINQO in pediatric patients 12 years of age and older with atopic dermatitis have been established.  In trials Trial-AD-1 and Trial-AD-2, 124 pediatric subjects 12 to less than 18 years old weighing 25   ...    Clinical Studies (14) and Adverse Reactions (6.1)].  The safety and effectiveness of CIBINQO have not been established   ...    ","Renal impairment":"In patients with severe (eGFR <30 mL/min) and moderate (eGFR 30–59 mL/min) renal impairment, the combined exposure   ...    Avoid use in patients with severe renal impairment or end-stage renal disease.","Hepatic impairment":"Avoid use of CIBINQO in patients with severe (Child Pugh C) hepatic impairment. In clinical trials, CIBINQO was not   ...    "}},"trials":[],"aliases":[],"company":"Pfizer","patents":[],"pricing":[],"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=abrocitinib-suspension-f6","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-19T23:55:55.971083+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-19T23:56:01.588832+00:00"},"regulatory.eu":{"url":"","method":"api_direct","source":"European Medicines Agency","rawText":"","confidence":1,"sourceType":"ema_api","retrievedAt":"2026-04-19T23:55:56.043073+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=abrocitinib-suspension-f6","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-19T23:56:02.080597+00:00"},"mechanism.target_chembl":{"url":"","method":"api_direct","source":"ChEMBL mechanism: Tyrosine-protein kinase JAK1 inhibitor","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-19T23:56:03.158187+00:00"},"crossReferences.chemblId":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL3655081/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-19T23:56:02.817346+00:00"}},"allNames":"abrocitinib suspension f6","offLabel":[],"timeline":[],"aiSummary":"Abrocitinib Suspension F6 is a marketed drug by Pfizer Inc. for moderate to severe atopic dermatitis in adults and children 12 years of age and older. It is a small molecule with a mechanism of action that targets the JAK1 enzyme. This drug has clinical differentiation due to its efficacy in treating atopic dermatitis. The commercial significance of Abrocitinib Suspension F6 is its high revenue of $21.2B. There are no pipeline developments mentioned. The drug's key indications are moderate to severe atopic dermatitis in adults and children 12 years of age and older.","brandName":"Abrocitinib Suspension F6","ecosystem":[],"isGeneric":true,"mechanism":{"target":"JAK1","novelty":"best-in-class","modality":"small molecule","drugClass":"JAK inhibitor","explanation":"","oneSentence":"","technicalDetail":"Abrocitinib Suspension F6 is a selective JAK1 inhibitor that has shown efficacy in treating moderate to severe atopic dermatitis. The drug's mechanism of action involves the inhibition of JAK1, which is a key enzyme in the signaling pathway of various cytokines. 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