{"id":"abraxane-carboplatin","safety":{"commonSideEffects":[{"rate":"40-60","effect":"Neutropenia"},{"rate":"30-50","effect":"Anemia"},{"rate":"20-40","effect":"Thrombocytopenia"},{"rate":"20-40","effect":"Peripheral neuropathy"},{"rate":"30-50","effect":"Nausea/vomiting"},{"rate":"40-60","effect":"Fatigue"},{"rate":"30-50","effect":"Alopecia"},{"rate":"5-10","effect":"Hypersensitivity reactions"}]},"_chembl":{"chemblId":"CHEMBL1351","moleculeType":"Small molecule","molecularWeight":"371.25"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Abraxane is a nanoparticle formulation of paclitaxel that binds to albumin for improved delivery and tolerability; it works by stabilizing microtubules and preventing their disassembly during mitosis. Carboplatin is a platinum-based alkylating agent that forms DNA adducts and crosslinks, blocking DNA replication and transcription. 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