{"id":"abp-959","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypocalcemia"},{"rate":null,"effect":"Osteonecrosis of the jaw"},{"rate":null,"effect":"Infection"}]},"_chembl":{"chemblId":"CHEMBL5796061","moleculeType":null,"molecularWeight":"491.59"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"ABP 959 targets RANKL (receptor activator of nuclear factor kappa-B ligand), a key mediator of osteoclast differentiation and activation. By inhibiting RANKL signaling, the drug reduces bone resorption and is being developed for conditions characterized by excessive bone loss. This mechanism is similar to denosumab, an established RANKL inhibitor.","oneSentence":"ABP 959 is a RANKL inhibitor that blocks osteoclast activation and bone resorption.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:58:40.457Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Giant cell tumor of bone"},{"name":"Bone metastases"}]},"trialDetails":[{"nctId":"NCT03818607","phase":"PHASE3","title":"A Study Evaluating the Efficacy and Safety of ABP 959 Compared With Eculizumab in Adult Participants With PNH","status":"COMPLETED","sponsor":"Amgen","startDate":"2019-01-22","conditions":"Paroxysmal Nocturnal Hemoglobinuria","enrollment":42}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":4,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Treatment T"],"phase":"phase_3","status":"active","brandName":"ABP 959","genericName":"ABP 959","companyName":"Amgen","companyId":"amgen","modality":"Small molecule","firstApprovalDate":"","aiSummary":"ABP 959 is a RANKL inhibitor that blocks osteoclast activation and bone resorption. Used for Giant cell tumor of bone, Bone metastases.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}