{"id":"abobotulinumtoxin-a","safety":{"commonSideEffects":[{"rate":"10-20","effect":"Injection site pain or bruising"},{"rate":"5-15","effect":"Headache"},{"rate":"5-10","effect":"Muscle weakness"},{"rate":"5-10","effect":"Neck pain"},{"rate":"5-15","effect":"Antibody formation (neutralizing)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This botulinum toxin serotype A derivative irreversibly cleaves SNAP-25, a protein essential for acetylcholine vesicle fusion and release. By preventing neurotransmitter release, it produces localized muscle relaxation lasting 3-4 months. The effect is temporary as the body regenerates new nerve terminals.","oneSentence":"Abobotulinumtoxin A blocks acetylcholine release at the neuromuscular junction by cleaving SNARE proteins, causing temporary muscle paralysis.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:58:42.196Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Cervical dystonia"},{"name":"Blepharospasm"},{"name":"Hemifacial spasm"},{"name":"Spasticity"},{"name":"Chronic migraine"},{"name":"Hyperhidrosis"}]},"trialDetails":[{"nctId":"NCT05158166","phase":"PHASE1, PHASE2","title":"DaxibotulinumtoxinA Injection for Treatment of Adductor Spasmodic Dysphonia","status":"COMPLETED","sponsor":"University of California, San Francisco","startDate":"2023-10-13","conditions":"Adductor Spasmodic Dysphonia, Voice Disorders, Spasmodic Dysphonia","enrollment":22},{"nctId":"NCT06807164","phase":"PHASE2","title":"Serratus Plane Block (SPB) Versus Capsaïcine Versus Botox-A for Chronic 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