{"id":"abiraterone-acetate-prednisolone","safety":{"commonSideEffects":[{"rate":"30–40","effect":"Hypertension"},{"rate":"15–25","effect":"Hypokalemia"},{"rate":"10–20","effect":"Fluid retention/edema"},{"rate":"15–25","effect":"Fatigue"},{"rate":"10–15","effect":"Joint swelling/arthralgia"},{"rate":"10–15","effect":"Diarrhea"},{"rate":"10–15","effect":"Urinary tract infection"},{"rate":"5–10","effect":"Elevated liver enzymes"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"anthropic-haiku","explanation":"Abiraterone acetate is a selective inhibitor of 17α-hydroxylase/17,20-lyase (CYP17A1), an enzyme critical for androgen biosynthesis in the adrenal glands and tumor microenvironment. By blocking this enzyme, it reduces circulating androgens and intratumoral androgen levels. Prednisolone is co-administered as a glucocorticoid to suppress ACTH-driven adrenal androgen production and mitigate mineralocorticoid excess caused by abiraterone, enhancing efficacy and tolerability.","oneSentence":"Abiraterone acetate inhibits CYP17A1 to block androgen synthesis, while prednisolone suppresses adrenocorticotropic hormone feedback to further reduce testosterone production in castration-resistant prostate cancer.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T02:20:26.540Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Castration-resistant prostate cancer (metastatic or non-metastatic)"},{"name":"Metastatic castration-sensitive prostate cancer (in combination with androgen deprivation therapy)"}]},"trialDetails":[{"nctId":"NCT06421935","phase":"PHASE1","title":"M9466 Alone or in Combination in Advanced Solid Tumors (DDriver 501)","status":"ACTIVE_NOT_RECRUITING","sponsor":"EMD Serono Research & Development Institute, 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testosterone production in castration-resistant prostate cancer. Used for Castration-resistant prostate cancer (metastatic or non-metastatic), Metastatic castration-sensitive prostate cancer (in combination with androgen deprivation therapy).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}