{"id":"abelmoschus-manihot-am","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal upset"},{"rate":null,"effect":"Allergic reactions"},{"rate":null,"effect":"Headache"}]},"_chembl":{"chemblId":"CHEMBL2074718","moleculeType":"Small molecule","molecularWeight":"994.87"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"AM contains polyphenols and flavonoids that scavenge reactive oxygen species and inhibit inflammatory cytokine production in renal tissue. It has been shown to stabilize the glomerular filtration barrier and reduce urinary protein loss in chronic kidney disease models and clinical use.","oneSentence":"Abelmoschus manihot is a herbal extract that reduces proteinuria and inflammation in kidney disease through antioxidant and anti-inflammatory pathways.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:21:36.436Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Chronic kidney disease with proteinuria"},{"name":"Lupus nephritis"},{"name":"IgA nephropathy"}]},"trialDetails":[{"nctId":"NCT02231125","phase":"PHASE4","title":"Efficacy and Safety of Abelmoschus Manihot for IgA Nephropathy","status":"UNKNOWN","sponsor":"Chen Xiangmei","startDate":"2014-09","conditions":"IgA Nephropathy","enrollment":1600},{"nctId":"NCT02231138","phase":"PHASE4","title":"Efficacy and Safety of Abelmoschus Manihot for Chronic Kidney Disease","status":"UNKNOWN","sponsor":"Chinese PLA General Hospital","startDate":"2014-09","conditions":"Chronic Kidney Disease","enrollment":1600}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":20,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Huanghui capsule"],"phase":"marketed","status":"active","brandName":"Abelmoschus manihot (AM)","genericName":"Abelmoschus manihot (AM)","companyName":"Chinese PLA General Hospital","companyId":"chinese-pla-general-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Abelmoschus manihot (AM) is a small molecule being studied for its potential efficacy and safety in treating Chronic Kidney Disease and IgA Nephropathy. It has been investigated in a multicentre open study, comparing its effects to Losartan, another treatment for Chronic Kidney Disease.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}