{"id":"abametapir-lotion-0-74-w-w","safety":{"commonSideEffects":[{"rate":null,"effect":"Application site erythema"},{"rate":null,"effect":"Application site irritation"},{"rate":null,"effect":"Scalp irritation"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Abametapir works by blocking zinc-dependent metalloproteinases in head lice, which are essential enzymes the parasites use to penetrate skin and obtain blood meals. By inhibiting these enzymes, the drug prevents lice from feeding and reproducing, leading to their death. This novel mechanism of action differs from traditional neurotoxic pediculicides, potentially offering advantages in resistance management.","oneSentence":"Abametapir is a topical pediculicide that inhibits lice metalloproteinases, disrupting their ability to feed and survive on the scalp.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:58:22.319Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Head lice infestation (Pediculosis capitis)"}]},"trialDetails":[{"nctId":"NCT02061813","phase":"PHASE1","title":"Dermal Safety Study to Evaluate Potential Irritation of Abametapir Lotion","status":"COMPLETED","sponsor":"Dr. Reddy's Laboratories Limited","startDate":"2014-01","conditions":"Head Lice","enrollment":40},{"nctId":"NCT02097485","phase":"PHASE2","title":"Ovicidal Efficacy and Safety of Abametapir Lotion 0.74% Administered for the Treatment of Head Lice Infestation","status":"COMPLETED","sponsor":"Dr. Reddy's Laboratories Limited","startDate":"2014-05","conditions":"Head Lice Infestation","enrollment":50},{"nctId":"NCT02060903","phase":"PHASE3","title":"A Study of the Efficacy and Safety of Abametapir Lotion Administered for the Treatment of Head Lice Infestation","status":"COMPLETED","sponsor":"Dr. Reddy's Laboratories Limited","startDate":"2014-02","conditions":"Head Lice Infestation","enrollment":379},{"nctId":"NCT02062060","phase":"PHASE3","title":"Study of the Efficacy and Safety of Abametapir Lotion Administered for the Treatment of Head Lice Infestation","status":"COMPLETED","sponsor":"Dr. Reddy's Laboratories Limited","startDate":"2014-02","conditions":"Head Lice Infestation","enrollment":325},{"nctId":"NCT02062073","phase":"PHASE1","title":"Dermal Safety Study to Evaluate the Sensitizing Potential of Abametapir Lotion","status":"COMPLETED","sponsor":"Dr. Reddy's Laboratories Limited","startDate":"2014-01","conditions":"Head Lice","enrollment":238}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Abametapir 0.74%"],"phase":"phase_3","status":"active","brandName":"Abametapir Lotion 0.74% w/w","genericName":"Abametapir Lotion 0.74% w/w","companyName":"Dr. Reddy's Laboratories Limited","companyId":"dr-reddy-s-laboratories-limited","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Abametapir is a topical pediculicide that inhibits lice metalloproteinases, disrupting their ability to feed and survive on the scalp. Used for Head lice infestation (Pediculosis capitis).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}