{"id":"aav8-hlca5","safety":{"commonSideEffects":[]},"_chembl":{"chemblId":"CHEMBL4594321","moleculeType":"Gene"},"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"AAV8.hLCA5 is a gene therapy vector that delivers a healthy copy of the LCA5 gene to photoreceptor cells in the retina, treating Leber congenital amaurosis 10 (LCA10).","oneSentence":"Gene therapy for Leber congenital amaurosis 10 (LCA10)","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T04:51:21.900Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Leber congenital amaurosis 10 (LCA10)"}]},"trialDetails":[{"nctId":"NCT05616793","phase":"PHASE1, PHASE2","title":"Safety and Tolerability Subretinal OPGx-001 for LCA5-Associated Inherited Retinal Degeneration (LCA5-IRD) and Non-interventional Arm With Untreated Patients","status":"RECRUITING","sponsor":"Opus Genetics, Inc","startDate":"2023-06-15","conditions":"LCA5","enrollment":22}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_1","status":"active","brandName":"AAV8.hLCA5","genericName":"AAV8.hLCA5","companyName":"Opus Genetics, Inc","companyId":"opus-genetics-inc","modality":"Biologic","firstApprovalDate":"","aiSummary":"Gene therapy for Leber congenital amaurosis 10 (LCA10) Used for Leber congenital amaurosis 10 (LCA10).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":true,"score":3}}