{"id":"aav-htert","safety":{"commonSideEffects":[]},"_chembl":{"chemblId":"CHEMBL4594561","moleculeType":"Vaccine component"},"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"AAV vectors are used to deliver the human telomerase reverse transcriptase (hTERT) gene to cells, which can lead to the activation of telomerase and the extension of telomeres, potentially leading to the regeneration of cells and tissues.","oneSentence":"AAV-mediated delivery of the hTERT gene","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T04:51:19.541Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Telomere-related disorders"}]},"trialDetails":[{"nctId":"NCT04133649","phase":"PHASE1","title":"Evaluation of Safety and Tolerability of Libella Gene Therapy for the Treatment of Aging: AAV- hTERT","status":"UNKNOWN","sponsor":"Libella Gene Therapeutics","startDate":"2019-10-17","conditions":"Aging","enrollment":5},{"nctId":"NCT04133454","phase":"PHASE1","title":"Evaluation of Safety and Tolerability of Libella Gene Therapy for Alzheimer's Disease: AAV- hTERT","status":"UNKNOWN","sponsor":"Libella Gene Therapeutics","startDate":"2019-10-10","conditions":"Alzheimer Disease","enrollment":5},{"nctId":"NCT04110964","phase":"PHASE1","title":"Evaluation of Safety and Tolerability of Libella Gene Therapy for Critical Limb Ischemia: AAV- hTERT","status":"UNKNOWN","sponsor":"Libella Gene Therapeutics","startDate":"2019-09-26","conditions":"Critical Limb Ischemia","enrollment":5}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":5,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["LGT"],"phase":"phase_1","status":"active","brandName":"AAV-hTERT","genericName":"AAV-hTERT","companyName":"Libella Gene Therapeutics","companyId":"libella-gene-therapeutics","modality":"Small molecule","firstApprovalDate":"","aiSummary":"AAV-mediated delivery of the hTERT gene Used for Telomere-related disorders.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":true,"score":3}}