{"id":"a-101-solution-40","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"dry skin"},{"rate":"5-10%","effect":"itching"},{"rate":"5-10%","effect":"redness"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"It works by inhibiting the sympathetic nervous system's ability to stimulate sweat glands, thereby reducing excessive sweating. The exact molecular target is not well-documented, but it is believed to involve the inhibition of acetylcholine release or its action on muscarinic receptors.","oneSentence":"A-101 Solution 40 is a topical solution used to treat hyperhidrosis.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T02:27:56.398Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Treatment of primary axillary hyperhidrosis"}]},"trialDetails":[{"nctId":"NCT02260180","phase":"PHASE2","title":"Study of A-101 for the Treatment of Seborrheic Keratosis","status":"COMPLETED","sponsor":"Aclaris Therapeutics, Inc.","startDate":"2014-10","conditions":"Seborrheic Keratosis","enrollment":119},{"nctId":"NCT03224598","phase":"PHASE2","title":"A Study of A-101 Topical Solution in Subjects With Dermatosis Papulosa Nigra","status":"COMPLETED","sponsor":"Aclaris Therapeutics, Inc.","startDate":"2017-06-26","conditions":"Dermatosis Papulosa Nigra","enrollment":39},{"nctId":"NCT03487588","phase":"PHASE4","title":"An A Study Assessing Subject Satisfaction With A-101 Topical Solution for Seborrheic Keratoses","status":"COMPLETED","sponsor":"Aclaris Therapeutics, Inc.","startDate":"2018-03-21","conditions":"Seborrheic Keratosis","enrollment":41},{"nctId":"NCT02160626","phase":"PHASE2","title":"Dose-Response Profile of A-101 in Subjects With Seborrheic Keratosis","status":"COMPLETED","sponsor":"Aclaris Therapeutics, Inc.","startDate":"2014-06","conditions":"Seborrheic Keratosis","enrollment":172},{"nctId":"NCT01986920","phase":"PHASE1, PHASE2","title":"Study of Safety, Tolerability and Effectiveness of A-101 in Subjects With Seborrheic Keratosis","status":"COMPLETED","sponsor":"Aclaris Therapeutics, Inc.","startDate":"2013-10-22","conditions":"Seborrheic Keratosis (SK)","enrollment":35},{"nctId":"NCT02669862","phase":"PHASE2","title":"A Study of A-101 Solution in Subjects With Common Warts.","status":"COMPLETED","sponsor":"Aclaris Therapeutics, Inc.","startDate":"2015-12-21","conditions":"Common Warts","enrollment":98},{"nctId":"NCT02667288","phase":"PHASE3","title":"An Open-Label Safety Study of A-101 Solution","status":"COMPLETED","sponsor":"Aclaris Therapeutics, Inc.","startDate":"2016-01","conditions":"Seborrheic Keratosis","enrollment":147},{"nctId":"NCT02667275","phase":"PHASE3","title":"A Randomized, Double-Blind, Vehicle-Controlled Study in Subjects With Seborrheic Keratosis","status":"COMPLETED","sponsor":"Aclaris Therapeutics, Inc.","startDate":"2016-01","conditions":"Seborrheic Keratosis","enrollment":487},{"nctId":"NCT02667236","phase":"PHASE3","title":"A Study of A-101 Solution 40% in Subjects With Seborrheic Keratosis.","status":"COMPLETED","sponsor":"Aclaris Therapeutics, Inc.","startDate":"2016-01","conditions":"Seborrheic Keratosis","enrollment":450}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":2,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_2","status":"active","brandName":"A-101 Solution 40","genericName":"A-101 Solution 40","companyName":"Aclaris Therapeutics, Inc.","companyId":"aclaris-therapeutics-inc","modality":"Small molecule","firstApprovalDate":"","aiSummary":"A-101 Solution 40 is a topical solution used to treat hyperhidrosis. Used for Treatment of primary axillary hyperhidrosis.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}