{"id":"6mpfixed","safety":{"commonSideEffects":[{"rate":null,"effect":"Myelosuppression (leukopenia, thrombocytopenia)"},{"rate":null,"effect":"Hepatotoxicity"},{"rate":null,"effect":"Nausea and vomiting"},{"rate":null,"effect":"Increased infection risk"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"6MP is converted intracellularly to active metabolites that interfere with purine metabolism, reducing the synthesis of DNA and RNA. This leads to decreased proliferation of lymphocytes and other rapidly dividing cells, making it effective as both an immunosuppressant and antileukemic agent. The 'fixed' designation likely refers to a fixed-dose formulation.","oneSentence":"6MP (6-mercaptopurine) is a purine analog that inhibits nucleotide synthesis and suppresses immune cell proliferation.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:58:09.174Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute lymphoblastic leukemia (ALL)"},{"name":"Inflammatory bowel disease (Crohn's disease, ulcerative colitis)"}]},"trialDetails":[{"nctId":"NCT00816049","phase":"PHASE3","title":"ALL2008 Protocol for Childhood Acute Lymphoblastic Leukemia (ALL) - 6MP Consolidation Therapy","status":"COMPLETED","sponsor":"Rigshospitalet, Denmark","startDate":"2009-01","conditions":"Acute Lymphoblastic Leukemia","enrollment":775}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["PuriNethol, Puri-Nethol (6-mercaptopurine)"],"phase":"phase_3","status":"active","brandName":"6MPfixed","genericName":"6MPfixed","companyName":"Rigshospitalet, Denmark","companyId":"rigshospitalet-denmark","modality":"Small molecule","firstApprovalDate":"","aiSummary":"6MP (6-mercaptopurine) is a purine analog that inhibits nucleotide synthesis and suppresses immune cell proliferation. Used for Acute lymphoblastic leukemia (ALL), Inflammatory bowel disease (Crohn's disease, ulcerative colitis).","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}