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It also has immunosuppressive effects through inhibition of T-cell proliferation.","oneSentence":"6MP (6-mercaptopurine) is a purine analog that inhibits nucleotide synthesis and DNA replication, leading to cell death in rapidly dividing cells.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:20:34.779Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute lymphoblastic leukemia (ALL)"},{"name":"Acute myeloid leukemia (AML)"},{"name":"Chronic myeloid leukemia (CML)"}]},"trialDetails":[{"nctId":"NCT06317662","phase":"PHASE2","title":"Testing the Addition of the Anti-cancer Drug Venetoclax and/or the Anti-cancer Immunotherapy Blinatumomab to the Usual Chemotherapy Treatment for Infants With Newly Diagnosed KMT2A-rearranged or KMT2A-non-rearranged Leukemia","status":"RECRUITING","sponsor":"National Cancer Institute (NCI)","startDate":"2025-06-05","conditions":"Acute Leukemia of Ambiguous Lineage, B Acute Lymphoblastic 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