{"id":"5-hydroxytryptophan","safety":{"commonSideEffects":[{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Gastrointestinal upset"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Serotonin syndrome (rare, especially with concurrent serotonergic agents)"}]},"_chembl":{"chemblId":"CHEMBL350221","moleculeType":"Small molecule","molecularWeight":"220.23"},"_dailymed":{"setId":"5c0ff0d8-2db4-42c0-9b6d-572f9ad0c98b","title":"ELEVATE (LYCOPODIUM CLAVATUM, NATRUM MURIATICUM, SEPIA, CAUSTICUM, PHOSPHORUS, SULPHUR, 5-HYDROXYTRYPTOPHAN, ALUMINA, SILICEA, ACETYLCHOLINE CHLORIDE, DOPAMINE HYDROCHLORIDE, NOREPINEPHRINE (BITARTRATE), PHENYLETHYLAMINE (HYDROCHLORIDE), SEROTONIN (HYDROCHLORIDE), ADENOSINUM CYCLOPHOSPHORICUM, CEREBRUM (SUIS), DIENCEPHALON (SUIS), FUNICULUS UMBILICALIS SUIS, PANTOTHENIC ACID, PINEAL GLAND (SUIS), SARCOLACTICUM ACIDUM, FAECALIS (ALKALIGENES), GAERTNER BACILLUS (BACH), PROTEUS (VULGARIS)) LIQUID [DESERET BIOLOGICALS, INC.]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"5-HTP is an amino acid intermediate in the serotonin synthesis pathway. After oral administration, it crosses the blood-brain barrier more efficiently than serotonin itself and is converted to serotonin by the enzyme aromatic amino acid decarboxylase. This increases synaptic serotonin availability, which modulates mood, sleep, and other serotonin-dependent functions.","oneSentence":"5-Hydroxytryptophan (5-HTP) is a precursor to serotonin that increases central nervous system serotonin levels by crossing the blood-brain barrier and being converted to serotonin via aromatic amino acid decarboxylase.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T02:59:25.539Z","_scrapedBy":"cloudflare-swarm","_wikipedia":{"url":"https://en.wikipedia.org/wiki/5-Hydroxytryptophan","title":"5-Hydroxytryptophan","extract":"5-Hydroxytryptophan (5-HTP), used medically as oxitriptan, is a naturally occurring amino acid and chemical precursor as well as a metabolic intermediate in the biosynthesis of the neurotransmitter serotonin."},"indications":{"approved":[{"name":"Depression"},{"name":"Anxiety"},{"name":"Sleep disorders"},{"name":"Fibromyalgia"}]},"trialDetails":[{"nctId":"NCT04160910","phase":"PHASE2","title":"5HTP Regulation Of Asthma In Children","status":"RECRUITING","sponsor":"Indiana University","startDate":"2021-02-11","conditions":"Mild or Moderate Asthma With Allergic Sensitization","enrollment":20},{"nctId":"NCT06718452","phase":"NA","title":"Tinnitus and Treatment With umPEA-LUT","status":"NOT_YET_RECRUITING","sponsor":"University of Campania Luigi Vanvitelli","startDate":"2026-04-20","conditions":"Tinnitus, Neuroinflammation","enrollment":100},{"nctId":"NCT07190989","phase":"NA","title":"A Replicate Crossover Trial on Nutritional Supplementation in Association Football (Soccer)","status":"COMPLETED","sponsor":"Aspire Academy","startDate":"2025-09-21","conditions":"Healthy","enrollment":15},{"nctId":"NCT04520178","phase":"PHASE2, PHASE3","title":"Effects of 5HTP on the Injured Human Spinal Cord","status":"RECRUITING","sponsor":"University of Alberta","startDate":"2020-07-01","conditions":"Spinal Cord Injuries","enrollment":30},{"nctId":"NCT05895747","phase":"PHASE2","title":"5-HTP and Creatine for Depression R33 Phase","status":"RECRUITING","sponsor":"University of Utah","startDate":"2023-09-28","conditions":"Major Depressive Disorder","enrollment":106},{"nctId":"NCT06893822","phase":"NA","title":"The Effect of Griffonia Simplicifolia on Pain Intensity, Central and Peripheral Sensitization, Painmodulation in Healthy Volunteers","status":"RECRUITING","sponsor":"Medical University of Graz","startDate":"2025-09-12","conditions":"Chronic Pain, Central Sensitisation, Peripheral Sensitization","enrollment":20},{"nctId":"NCT05216406","phase":"NA","title":"Effects of Daily Supplementation of 5-HTP on Body Composition","status":"COMPLETED","sponsor":"Nova Southeastern University","startDate":"2021-01-01","conditions":"Body Composition","enrollment":65},{"nctId":"NCT05401032","phase":"PHASE2","title":"Proof-of-concept Study to Evaluate the Safety and Efficacy of Tryptophan in Patients with BPH.","status":"RECRUITING","sponsor":"Clinical Academic Center (2CA-Braga)","startDate":"2024-12-20","conditions":"BPH, LUTS(Lower Urinary Tract Symptoms)","enrollment":70},{"nctId":"NCT05030129","phase":"PHASE2","title":"ERG/5-HTP in Fragile X Syndrome (FXS)","status":"COMPLETED","sponsor":"Elizabeth Berry-Kravis","startDate":"2021-10-07","conditions":"Fragile X Syndrome","enrollment":15},{"nctId":"NCT02509143","phase":"NA","title":"Acupuncture for Postoperative Nausea and Vomiting in Patients Undergoing Colorectal Surgery","status":"COMPLETED","sponsor":"Pusan National University Yangsan Hospital","startDate":"2015-07","conditions":"Postoperative Nausea and Vomiting, Colorectal Neoplasms","enrollment":60},{"nctId":"NCT04395183","phase":"PHASE2","title":"5-HTP and Creatine for Depression","status":"COMPLETED","sponsor":"University of Utah","startDate":"2021-03-01","conditions":"Major Depressive Disorder","enrollment":43},{"nctId":"NCT05363254","phase":"NA","title":"CSD200902: Assessment of Indoor Air Quality for a Heated Tobacco Product With Four Non-Combusted Cigarette Variants in an Environmental Testing Chamber","status":"COMPLETED","sponsor":"RAI Services Company","startDate":"2022-05-23","conditions":"Tobacco Use, Smoking, Tobacco Smoking","enrollment":120},{"nctId":"NCT06018168","phase":"NA","title":"An RCT Evaluating the Efficacy of a Skincare Routine and Acne Supplement on Improving Acne and Other Symptoms of PMS","status":"COMPLETED","sponsor":"Clearstem Skincare","startDate":"2023-06-30","conditions":"Acne, Premenstrual Syndrome","enrollment":60},{"nctId":"NCT05543811","phase":"NA","title":"The Influence of Food for Special Dietary Use - Spread Enriched With 5-hydroxytryptophan, Theanine and Gamma-aminobutyric Acid on Psychophysiological Functions of Subjects Without Meaningful Organic and Cognitive Pathology","status":"COMPLETED","sponsor":"Federal State Budgetary Scientific Institution \"Federal Research Centre of Nutrition, Biotechnology","startDate":"2022-09-15","conditions":"Cognitive Change, Memory; Disturbance, Mild, Emotional Regulation","enrollment":140},{"nctId":"NCT04000919","phase":"PHASE2, PHASE3","title":"Effects of 5HTP and LDOPA on CNS Excitability After SCI","status":"SUSPENDED","sponsor":"Jessica M D'Amico","startDate":"2019-06-19","conditions":"Spinal Cord Injuries","enrollment":30},{"nctId":"NCT02922725","phase":"PHASE4","title":"Placebo-controlled Trial of 5-hydroxytryptophan and Creatine for SSRI or SNRI Augmentation in Treatment Resistant Depression in Females","status":"TERMINATED","sponsor":"Brent Michael Kious, MD, PhD","startDate":"2016-11","conditions":"Major Depressive Disorder","enrollment":32},{"nctId":"NCT04078724","phase":"NA","title":"Impact of Nutritional Supplementation on Sleep Quality and Gut Microbiome Composition in Older Adults","status":"COMPLETED","sponsor":"National University of Singapore","startDate":"2020-07-04","conditions":"Sleep, Gut Microbiome","enrollment":33},{"nctId":"NCT03574948","phase":"PHASE2","title":"5-HTP in Patients With IBD in Clinical and Biologic Remission:Effect on Fatigue Scores","status":"COMPLETED","sponsor":"University Hospital, Ghent","startDate":"2018-12-06","conditions":"Crohn Disease, Ulcerative Colitis, Fatigue","enrollment":175},{"nctId":"NCT03112655","phase":"NA","title":"Diagnostic Tools for Human African Trypanosomiasis Elimination and Clinical Trials: Early Test-of-cure","status":"COMPLETED","sponsor":"Institut de Recherche pour le Developpement","startDate":"2017-02-24","conditions":"African Trypanosomiasis, African; Trypanosomiasis, West, Sleeping Sickness; West African","enrollment":88},{"nctId":"NCT03364101","phase":"NA","title":"The Poweroff Sleep Study","status":"COMPLETED","sponsor":"NYU Langone Health","startDate":"2017-10-01","conditions":"Sleep","enrollment":60},{"nctId":"NCT00227136","phase":"PHASE3","title":"Effect of Oral 5-HTP Intake on Urinary 5-HIAA Excretion","status":"TERMINATED","sponsor":"University of Western Ontario, Canada","startDate":"2005-05","conditions":"Carcinoid Tumors, Neuroendocrine Tumors","enrollment":8},{"nctId":"NCT02967354","phase":"NA","title":"[11C]5-Hydroxy-tryptophan PET for Assessment of Islet Mass in Type 2 Diabetes","status":"COMPLETED","sponsor":"Per-Ola Carlsson","startDate":"2013-01","conditions":"Type2 Diabetes","enrollment":39},{"nctId":"NCT02356107","phase":"PHASE4","title":"5-hydroxytryptophan and Creatine for Treatment Resistant Depression Associated With Hypoxia in Females","status":"COMPLETED","sponsor":"Perry Renshaw","startDate":"2015-04","conditions":"Major Depressive Disorder","enrollment":15},{"nctId":"NCT02689479","phase":"NA","title":"11C-5-HTP PET in Clinical Islet Transplantation","status":"COMPLETED","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"2013-05","conditions":"Type 1 Diabetes","enrollment":8},{"nctId":"NCT00731003","phase":"NA","title":"The Effect of Serotonergic Modulation on Intestinal Permeability and Visceral Hypersensitivity in Healthy Individuals and Irritable Bowel Syndrome (IBS) Patients","status":"COMPLETED","sponsor":"Maastricht University Medical Center","startDate":"2009-04","conditions":"Irritable Bowel Syndrome","enrollment":60},{"nctId":"NCT02187341","phase":"NA","title":"Effects of Exercise and 5-HTP on Cortisol Levels","status":"UNKNOWN","sponsor":"Benedictine University","startDate":"2014-06","conditions":"Plasma Cortisol","enrollment":12},{"nctId":"NCT01514409","phase":"NA","title":"Sub-chronic Effects of 5-hydroxytryptophan on Mood and Emotional Processing in Healthy Volunteers","status":"COMPLETED","sponsor":"Northumbria University","startDate":"2011-05","conditions":"Mood","enrollment":33},{"nctId":"NCT00328913","phase":"PHASE2","title":"The Effect of 5-Hydroxytryptophan (5-HTP) on Satiety","status":"COMPLETED","sponsor":"TNO","startDate":"2006-03","conditions":"Obesity","enrollment":24}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":2958,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["5-HTP, Basic Vitamins","5HTP"],"phase":"marketed","status":"active","brandName":"5-Hydroxytryptophan","genericName":"5-Hydroxytryptophan","companyName":"Elizabeth Berry-Kravis","companyId":"elizabeth-berry-kravis","modality":"Small molecule","firstApprovalDate":"","aiSummary":"5-Hydroxytryptophan (5-HTP) is a precursor to serotonin that increases central nervous system serotonin levels by crossing the blood-brain barrier and being converted to serotonin via aromatic amino acid decarboxylase. Used for Depression (off-label use), Insomnia (off-label use), Fibromyalgia (off-label use).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":3,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}