{"id":"5-hidroxitriptophan","safety":{"commonSideEffects":[{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Gastrointestinal upset"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Serotonin syndrome (rare, with concurrent serotonergic agents)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"anthropic-haiku","explanation":"5-HTP is an amino acid intermediate in the serotonin synthesis pathway. It is more effective than L-tryptophan at raising brain serotonin because it bypasses the rate-limiting step of tryptophan hydroxylase and crosses the blood-brain barrier more efficiently. Increased serotonin availability can improve mood, reduce pain perception, and normalize sleep-wake cycles.","oneSentence":"5-hydroxytryptophan (5-HTP) is a precursor to serotonin that increases central nervous system serotonin levels by crossing the blood-brain barrier and being converted to serotonin via aromatic amino acid decarboxylase.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T02:26:52.802Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Depression"},{"name":"Anxiety disorders"},{"name":"Fibromyalgia"},{"name":"Sleep disorders"}]},"trialDetails":[{"nctId":"NCT05401032","phase":"PHASE2","title":"Proof-of-concept Study to Evaluate the Safety and Efficacy of Tryptophan in Patients with BPH.","status":"RECRUITING","sponsor":"Clinical Academic Center (2CA-Braga)","startDate":"2024-12-20","conditions":"BPH, LUTS(Lower Urinary Tract Symptoms)","enrollment":70}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Cincofarm"],"phase":"phase_2","status":"active","brandName":"5-hidroxitriptophan","genericName":"5-hidroxitriptophan","companyName":"Clinical Academic Center (2CA-Braga)","companyId":"clinical-academic-center-2ca-braga","modality":"Small molecule","firstApprovalDate":"","aiSummary":"5-hydroxytryptophan (5-HTP) is a precursor to serotonin that increases central nervous system serotonin levels by crossing the blood-brain barrier and being converted to serotonin via aromatic amino acid decarboxylase. Used for Depression, Anxiety disorders, Fibromyalgia.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}