{"id":"5-fluorouracil-oxaliplatin","safety":{"commonSideEffects":[{"rate":"40-50","effect":"Neutropenia"},{"rate":"30-40","effect":"Anemia"},{"rate":"20-30","effect":"Thrombocytopenia"},{"rate":"50-70","effect":"Nausea and vomiting"},{"rate":"40-50","effect":"Diarrhea"},{"rate":"30-40","effect":"Peripheral neuropathy"},{"rate":"20-30","effect":"Mucositis"},{"rate":"50-60","effect":"Fatigue"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"5-fluorouracil (5-FU) is a pyrimidine antimetabolite that blocks thymidylate synthase, preventing dTMP synthesis and disrupting DNA replication. Oxaliplatin is a third-generation platinum compound that forms interstrand and intrastrand DNA cross-links, leading to apoptosis. The combination (often called FOLFOX when combined with leucovorin and fluorouracil) exploits complementary mechanisms to enhance cytotoxicity against rapidly dividing cancer cells.","oneSentence":"5-fluorouracil inhibits thymidylate synthase to disrupt DNA synthesis, while oxaliplatin forms DNA cross-links, together providing synergistic cytotoxic effects against cancer cells.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:57:39.042Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Colorectal cancer (metastatic and adjuvant settings)"},{"name":"Gastric cancer"},{"name":"Pancreatic cancer"},{"name":"Ovarian cancer"}]},"trialDetails":[{"nctId":"NCT06948448","phase":"PHASE2","title":"A Study to Evaluate the Safety and Efficacy of Two Dose Levels of ONO-4578 With Opdivo®, in Combination With mFOLFOX6 and Bevacizumab Versus Standard of Care in Participants With Non-MSI-H/dMMR, PD-L1 Positive Advanced Colorectal Cancer","status":"RECRUITING","sponsor":"Ono Pharmaceutical Co. 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