{"id":"5-azacytidin","safety":{"commonSideEffects":[{"rate":null,"effect":"Myelosuppression (anemia, thrombocytopenia, neutropenia)"},{"rate":null,"effect":"Nausea and vomiting"},{"rate":null,"effect":"Fatigue"},{"rate":null,"effect":"Injection site reactions"},{"rate":null,"effect":"Fever"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"5-Azacytidine is a cytidine analog that incorporates into DNA during replication and inhibits DNA methyltransferase (DNMT) activity, leading to hypomethylation of CpG islands. This reactivates epigenetically silenced genes, including tumor suppressors, and can induce differentiation and apoptosis in myelodysplastic and other cancer cells. It also has immunomodulatory effects that enhance anti-tumor immunity.","oneSentence":"5-Azacytidine is a DNA methyltransferase inhibitor that reduces DNA methylation and promotes re-expression of silenced tumor suppressor genes.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:57:33.054Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Myelodysplastic syndromes"},{"name":"Acute myeloid leukemia"}]},"trialDetails":[{"nctId":"NCT00422890","phase":"PHASE3","title":"Treatment of Imminent Haematological Relapse in Patients With AML and MDS Following Allogeneic Stem Cell Transplantation With 5-azacitidine (Vidaza®)","status":"COMPLETED","sponsor":"Technische Universität Dresden","startDate":"2007-01","conditions":"Myeloid Leukemia, Myelodysplastic Syndrome","enrollment":10}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":9,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"5-Azacytidin","genericName":"5-Azacytidin","companyName":"Technische Universität Dresden","companyId":"technische-universit-t-dresden","modality":"Small molecule","firstApprovalDate":"","aiSummary":"5-Azacytidine is a DNA methyltransferase inhibitor that reduces DNA methylation and promotes re-expression of silenced tumor suppressor genes. Used for Myelodysplastic syndromes, Acute myeloid leukemia.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}