{"id":"4d-710","safety":{"commonSideEffects":[{"rate":null,"effect":"Pulmonary exacerbations"},{"rate":null,"effect":"Respiratory infections"},{"rate":null,"effect":"Hemoptysis"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"This approach aims to restore normal CFTR protein function, which is essential for the proper functioning of chloride channels in the lungs, thereby improving lung function and reducing the risk of pulmonary exacerbations. By delivering the CFTR gene directly to the lungs, 4D-710 seeks to bypass the need for systemic gene therapy and minimize potential off-target effects.","oneSentence":"4D-710 is a gene therapy that uses an adeno-associated virus to deliver a functional copy of the CFTR gene to the lungs, correcting the underlying genetic defect in cystic fibrosis.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T02:26:30.374Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Cystic fibrosis"}]},"trialDetails":[{"nctId":"NCT05248230","phase":"PHASE2","title":"4D-710 in Adult Patients With Cystic Fibrosis","status":"RECRUITING","sponsor":"4D Molecular Therapeutics","startDate":"2022-03-29","conditions":"Cystic Fibrosis Lung","enrollment":30}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_2","status":"active","brandName":"4D-710","genericName":"4D-710","companyName":"4D Molecular Therapeutics","companyId":"4d-molecular-therapeutics","modality":"Biologic","firstApprovalDate":"","aiSummary":"4D-710 is a gene therapy that uses an adeno-associated virus to deliver a functional copy of the CFTR gene to the lungs, correcting the underlying genetic defect in cystic fibrosis. Used for Cystic fibrosis.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}