{"id":"23vppv-tiv","safety":{"commonSideEffects":[{"rate":null,"effect":"Injection site pain or erythema"},{"rate":null,"effect":"Fever"},{"rate":null,"effect":"Myalgia"},{"rate":null,"effect":"Fatigue"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"23vPPV+TIV is a bivalent vaccine combining 23-valent pneumococcal polysaccharide vaccine (23vPPV) and trivalent inactivated influenza vaccine (TIV). The pneumococcal component provides protection against 23 serotypes of S. pneumoniae through polysaccharide-based immunity, while the influenza component induces antibody responses against three seasonal influenza strains. This combination vaccine approach allows simultaneous immunization against both pathogens in a single administration.","oneSentence":"A combined pneumococcal and influenza vaccine that stimulates immune responses against 23 serotypes of Streptococcus pneumoniae and seasonal influenza virus strains.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:25:20.133Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Prevention of pneumococcal disease caused by 23 serotypes of Streptococcus pneumoniae"},{"name":"Prevention of seasonal influenza"}]},"trialDetails":[{"nctId":"NCT02062281","phase":"PHASE4","title":"Study of Evaluating Safety and Immunogenicity of 23-Valent Pneumococcal Polysaccharide Vaccine With Influenza Vaccine in Children and Adults","status":"COMPLETED","sponsor":"Jiangsu Province Centers for Disease Control and Prevention","startDate":"2013-11","conditions":"Pneumococcal Infection, Influenza","enrollment":2225}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"23vPPV+TIV","genericName":"23vPPV+TIV","companyName":"Jiangsu Province Centers for Disease Control and Prevention","companyId":"jiangsu-province-centers-for-disease-control-and-prevention","modality":"Biologic","firstApprovalDate":"","aiSummary":"This is a combined pneumococcal polysaccharide vaccine (23-valent) plus trivalent inactivated influenza vaccine that stimulates immune responses against 23 serotypes of Streptococcus pneumoniae and three influenza virus strains. Used for Prevention of pneumococcal disease caused by 23 serotypes of Streptococcus pneumoniae, Prevention of seasonal influenza.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}