{"id":"18fflutemetamol","rwe":[],"tags":[],"safety":{"drugInteractions":[{"drug":"Warfarin","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Aspirin","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Clopidogrel","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Pentosan polysulfate","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Dabigatran","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Rivaroxaban","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Apixaban","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Edoxaban","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Heparin","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Low molecular weight heparin","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Unfractionated heparin","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Bivalirudin","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Argatroban","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Fondaparinux","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Desirudin","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Bemiparin","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Nadroparin","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Tinzaparin","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Dalteparin","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Enoxaparin","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Tirofiban","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Abciximab","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Eptifibatide","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Alteplase","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Reteplase","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Tenecteplase","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Urokinase","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Streptokinase","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Anistreplase","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Dipyridamole","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Ticlopidine","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Cilostazol","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Clopidogrel","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Prasugrel","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Ticagrelor","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Cangrelor","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Esomeprazole","action":"Avoid","effect":"Decreased absorption of (18F)Flutemetamol"},{"drug":"Lansoprazole","action":"Avoid","effect":"Decreased absorption of (18F)Flutemetamol"},{"drug":"Omeprazole","action":"Avoid","effect":"Decreased absorption of (18F)Flutemetamol"},{"drug":"Pantoprazole","action":"Avoid","effect":"Decreased absorption of (18F)Flutemetamol"},{"drug":"Rabeprazole","action":"Avoid","effect":"Decreased absorption of (18F)Flutemetamol"},{"drug":"Famotidine","action":"Avoid","effect":"Decreased absorption of (18F)Flutemetamol"},{"drug":"Nizatidine","action":"Avoid","effect":"Decreased absorption of (18F)Flutemetamol"},{"drug":"Ranitidine","action":"Avoid","effect":"Decreased absorption of (18F)Flutemetamol"},{"drug":"Cimetidine","action":"Avoid","effect":"Decreased absorption of (18F)Flutemetamol"},{"drug":"Furosemide","action":"Avoid","effect":"Decreased absorption of (18F)Flutemetamol"},{"drug":"Hydrochlorothiazide","action":"Avoid","effect":"Decreased absorption of (18F)Flutemetamol"},{"drug":"Indapamide","action":"Avoid","effect":"Decreased absorption of (18F)Flutemetamol"},{"drug":"Metolazone","action":"Avoid","effect":"Decreased absorption of (18F)Flutemetamol"},{"drug":"Torsemide","action":"Avoid","effect":"Decreased absorption of (18F)Flutemetamol"},{"drug":"Triamterene","action":"Avoid","effect":"Decreased absorption of (18F)Flutemetamol"},{"drug":"Amiloride","action":"Avoid","effect":"Decreased absorption of (18F)Flutemetamol"},{"drug":"Spironolactone","action":"Avoid","effect":"Decreased absorption of (18F)Flutemetamol"},{"drug":"Triamterene","action":"Avoid","effect":"Decreased absorption of (18F)Flutemetamol"},{"drug":"Fosinopril","action":"Avoid","effect":"Decreased absorption of (18F)Flutemetamol"},{"drug":"Lisinopril","action":"Avoid","effect":"Decreased absorption of (18F)Flutemetamol"},{"drug":"Enalapril","action":"Avoid","effect":"Decreased absorption of (18F)Flutemetamol"},{"drug":"Captopril","action":"Avoid","effect":"Decreased absorption of (18F)Flutemetamol"},{"drug":"Quinapril","action":"Avoid","effect":"Decreased absorption of (18F)Flutemetamol"},{"drug":"Ramipril","action":"Avoid","effect":"Decreased absorption of (18F)Flutemetamol"},{"drug":"Perindopril","action":"Avoid","effect":"Decreased absorption of (18F)Flutemetamol"},{"drug":"Trandolapril","action":"Avoid","effect":"Decreased absorption of (18F)Flutemetamol"},{"drug":"Bisoprolol","action":"Avoid","effect":"Decreased absorption of (18F)Flutemetamol"},{"drug":"Metoprolol","action":"Avoid","effect":"Decreased absorption of (18F)Flutemetamol"},{"drug":"Nadolol","action":"Avoid","effect":"Decreased absorption of (18F)Flutemetamol"},{"drug":"Propranolol","action":"Avoid","effect":"Decreased absorption of (18F)Flutemetamol"},{"drug":"Pindolol","action":"Avoid","effect":"Decreased absorption of (18F)Flutemetamol"},{"drug":"Atenolol","action":"Avoid","effect":"Decreased absorption of (18F)Flutemetamol"},{"drug":"Bucindolol","action":"Avoid","effect":"Decreased absorption of (18F)Flutemetamol"},{"drug":"Carvedilol","action":"Avoid","effect":"Decreased absorption of (18F)Flutemetamol"},{"drug":"Labetalol","action":"Avoid","effect":"Decreased absorption of (18F)Flutemetamol"},{"drug":"Nebivolol","action":"Avoid","effect":"Decreased absorption of (18F)Flutemetamol"},{"drug":"Sotalol","action":"Avoid","effect":"Decreased absorption of (18F)Flutemetamol"},{"drug":"Esmolol","action":"Avoid","effect":"Decreased absorption of (18F)Flutemetamol"},{"drug":"Carteolol","action":"Avoid","effect":"Decreased absorption of (18F)Flutemetamol"},{"drug":"Betaxolol","action":"Avoid","effect":"Decreased absorption of (18F)Flutemetamol"},{"drug":"Bisoprolol","action":"Avoid","effect":"Decreased absorption of (18F)Flutemetamol"},{"drug":"Acebutolol","action":"Avoid","effect":"Decreased absorption of (18F)Flutemetamol"},{"drug":"Alprenolol","action":"Avoid","effect":"Decreased absorption of (18F)Flutemetamol"},{"drug":"Prenalterol","action":"Avoid","effect":"Decreased absorption of (18F)Flutemetamol"},{"drug":"Oxprenolol","action":"Avoid","effect":"Decreased absorption of (18F)Flutemetamol"},{"drug":"Pindolol","action":"Avoid","effect":"Decreased absorption of (18F)Flutemetamol"}],"contraindications":["Hypersensitivity to flutemetamol or to any of the excipients, known allergy to fluoride, and pregnancy or breastfeeding."],"specialPopulations":{"Pregnancy":"There are no available data on VIZAMYL use in pregnant women to evaluate for a drug-associated risk of major birth defects, miscarriage, or adverse maternal or fetal outcomes. All radiopharmaceuticals, including VIZAMYL, have the potential to cause fetal harm depending on the stage of fetal development and the magnitude of the radiation dose. If considering VIZAMYL administration to a pregnant woman, inform the patient about the potential for adverse pregnancy outcomes based on the radiation dose from VIZAMYL. To decrease radiation exposure to the breastfed infant, advise a lactating woman to interrupt breastfeeding, and pump and discard breast milk for 24 hours after administration of VIZAMYL.","Geriatric use":"Of the 761 subjects in clinical studies of VIZAMYL, 447 (59%) subjects were 65 years of age and older, while 246 subjects were 75 years of age and older. In patients with a range of cognitive impairment, mean cortical SUVR did not differ between patients taking or not taking VIZAMYL.","Paediatric use":"The safety and effectiveness of VIZAMYL have not been established in pediatric patients.","Renal impairment":"text not available","Hepatic impairment":"text not available"}},"trials":[],"_chembl":null,"aliases":[],"company":"Pfizer","patents":[],"pricing":[],"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=18fflutemetamol","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-19T23:53:05.363851+00:00"},"aiSummary":{"url":"","method":"ai_extraction","source":"AI Strategic Summary","aiModel":"featherless","rawText":"","confidence":0.9,"sourceType":"ai_extraction","retrievedAt":"2026-04-19T23:53:22.193484+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-19T23:53:12.294107+00:00"},"regulatory.eu":{"url":"","method":"api_direct","source":"European Medicines Agency","rawText":"","confidence":1,"sourceType":"ema_api","retrievedAt":"2026-04-19T23:53:05.435777+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=18fflutemetamol","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-19T23:53:12.583960+00:00"},"crossReferences.chemblId":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL579205/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-19T23:53:13.697495+00:00"}},"allNames":"(18f)flutemetamol","offLabel":[],"timeline":[],"_dailymed":null,"aiSummary":"(18F)Flutemetamol, marketed by Pfizer, is an amyloid imaging agent currently in use, competing directly with Florbetapir F 18, Florbetaben F 18, and another formulation of Flutemetamol F 18. A key strength is its established market presence, with a key composition patent expiring in 2028, providing some protection against generics. The primary risk lies in the competitive landscape, where multiple amyloid imaging agents are already marketed, potentially limiting revenue growth.","brandName":"(18F)Flutemetamol","ecosystem":[],"isGeneric":true,"mechanism":{"target":"unknown","novelty":"unknown","modality":"unknown","drugClass":"unknown","explanation":"","oneSentence":"","technicalDetail":"The technical details of (18F)Flutemetamol's mechanism of action are not available. As a result, healthcare professionals may find it difficult to prescribe the drug effectively. More information is needed to fully understand the drug's mechanism."},"_companyIR":{"url":"https://www.pfizer.com/investors","revenueRefs":[],"pipelineRefs":[]},"_scrapedAt":"2026-03-27T23:28:33.637Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"commercial":{"annualCostUS":"$80,000/yr","genericStatus":"Generic — off-patent","currentRevenue":"$21.2B","peakSalesEstimate":"$21.2B"},"references":[{"id":1,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=18fflutemetamol","fields":["publications"],"source":"PubMed/NCBI"},{"id":2,"url":"https://www.ebi.ac.uk/chembl/","fields":["molecular"],"source":"ChEMBL (EMBL-EBI)"},{"id":3,"url":"https://www.ema.europa.eu/","fields":["regulatoryStatus"],"source":"European Medicines Agency (EMA)"},{"id":4,"url":"https://list.essentialmeds.org/","fields":["regulatoryStatus"],"source":"WHO Essential Medicines List"}],"_tgaChecked":true,"_validation":{"fieldsValidated":1,"lastValidatedAt":"2026-04-19T23:53:22.193580+00:00","fieldsConflicting":1,"overallConfidence":0.8},"_whoChecked":true,"biosimilars":[],"competitors":[{"name":"Amyvid","company":"Eli Lilly and Company","advantage":"Amyvid is a positron emission tomography (PET) imaging agent that binds to beta-amyloid plaques in the brain, similar to (18F)Flutemetamol.","genericName":"Florbetapir F 18"},{"name":"Vizamyl","company":"Lantheus Medical Imaging, Inc.","advantage":"Vizamyl is a PET imaging agent that binds to beta-amyloid plaques in the brain, similar to (18F)Flutemetamol.","genericName":"Flutemetamol F 18"},{"name":"Neuraceq","company":"Lantheus Medical Imaging, Inc.","advantage":"Neuraceq is a PET imaging agent that binds to beta-amyloid plaques in the brain, similar to (18F)Flutemetamol.","genericName":"Florbetaben F 18"}],"genericName":"18fflutemetamol","indications":{"approved":[{"name":"Amyloid Imaging","regulator":"FDA"}],"offLabel":[],"pipeline":[]},"_mhraChecked":true,"labelChanges":[],"relatedDrugs":[],"trialDetails":[],"_emaApprovals":[{"date":"","name":"(18F)Flutemetamol","status":"Authorised","regulator":"EMA"}],"_faersSignals":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"molecularData":{"oral":false,"chemblId":"CHEMBL579205","moleculeType":"Small molecule","molecularWeight":"274.32"},"_patentsChecked":true,"_warningLetters":[{"date":"03/28/2023","subject":"11/07/2022\tTodos Medical Ltd aka Todos Medical USA Inc\tCenter for Food Safety and Applied Nutrition"},{"date":"03/27/2026","subject":"Feedback form"}],"crossReferences":{"chemblId":"CHEMBL579205"},"formularyStatus":[],"_approvalHistory":[],"_offLabelChecked":true,"developmentCodes":[],"ownershipHistory":[],"publicationCount":159,"therapeuticAreas":["Rare Disease"],"biosimilarFilings":[],"recentPublications":[],"_drugWebsiteChecked":true,"_healthCanadaChecked":true,"companionDiagnostics":[],"_genericFilersChecked":true,"genericManufacturerList":[],"phase":"marketed","status":"active","companyName":"Pfizer","companyId":"pfizer","modality":"unknown","firstApprovalDate":"","enrichmentLevel":3,"visitCount":3,"regulatoryByCountry":[{"country_code":"EU","regulator":"EMA","status":"pending","approval_date":null,"mah":"","brand_name_local":"","application_number":""},{"country_code":"CA","regulator":"Health Canada","status":"approved","approval_date":null,"mah":"","brand_name_local":"","application_number":""},{"country_code":"US","regulator":"FDA","status":"approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null}],"pricingByCountry":[{"country_code":"US","currency":"USD","price_amount":"80000.00","price_per":"year","price_type":"annual_list","annual_cost_usd":null,"reimbursement_status":null}],"trialStats":{"total":1,"withResults":0},"validation":{"fieldsValidated":1,"lastValidatedAt":"2026-04-19T23:53:22.193580+00:00","fieldsConflicting":1,"overallConfidence":0.8},"verificationStatus":"enriching","dataCompleteness":{"mechanism":false,"indications":true,"safety":false,"trials":false,"score":1}}