{"id":"18f-metafluorobenzylguanidine","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Myelosuppression"},{"rate":"10-20%","effect":"Nausea and vomiting"},{"rate":"5-10%","effect":"Fatigue"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"It works by exploiting the high uptake of metaiodobenzylguanidine (MIBG) by certain neuroendocrine cells, which are often overexpressed in these tumors. This allows for the visualization and treatment of these tumors with high precision.","oneSentence":"18F-metaFluorobenzylguanidine is a radiopharmaceutical that selectively accumulates in neuroendocrine tumors, allowing for targeted imaging and therapy.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T02:25:30.470Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Neuroblastoma"},{"name":"Pheochromocytoma"},{"name":"Paraganglioma"}]},"trialDetails":[{"nctId":"NCT06965621","phase":"PHASE2","title":"18F-mFBG Imaging for Myocardial Sympathetic Innervation","status":"NOT_YET_RECRUITING","sponsor":"Innervate Radiopharmaceuticals LLC (Formerly: Illumina Radiopharmaceuticals LLC)","startDate":"2026-04-28","conditions":"Heart Failure, Ischemic Cardiomyopathy, ICD Patients","enrollment":20},{"nctId":"NCT05069220","phase":"EARLY_PHASE1","title":"18F-MFBG PET/CT in the Evaluation of Neural Crest Tumor","status":"RECRUITING","sponsor":"Peking Union Medical College Hospital","startDate":"2021-09-01","conditions":"Neuroendocrine Tumor, Neuroblastoma, Pheochromocytoma","enrollment":150}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["IRP101"],"phase":"phase_2","status":"active","brandName":"18F-metaFluorobenzylguanidine","genericName":"18F-metaFluorobenzylguanidine","companyName":"Innervate Radiopharmaceuticals LLC (Formerly: Illumina Radiopharmaceuticals LLC)","companyId":"innervate-radiopharmaceuticals-llc-formerly-illumina-radiopharmaceuticals-llc","modality":"Small molecule","firstApprovalDate":"","aiSummary":"18F-metaFluorobenzylguanidine is a radiopharmaceutical that selectively accumulates in neuroendocrine tumors, allowing for targeted imaging and therapy. Used for Neuroblastoma, Pheochromocytoma, Paraganglioma.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}