{"id":"18f-florbetapir-pet-imaging","safety":{"commonSideEffects":[{"rate":null,"effect":"Injection site reactions"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Dizziness"}]},"_chembl":{"chemblId":"CHEMBL1774461","moleculeType":"Small molecule","molecularWeight":"359.43"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"[18F]Florbetapir is a fluorine-18 labeled tracer that crosses the blood-brain barrier and selectively binds to fibrillar amyloid-beta aggregates in the brain. The radioactive fluorine-18 isotope emits positrons that are detected by PET imaging, allowing quantitative and qualitative assessment of amyloid burden. This enables early detection and monitoring of amyloid pathology in neurodegenerative diseases, particularly Alzheimer's disease.","oneSentence":"[18F]Florbetapir is a positron emission tomography (PET) imaging agent that binds to amyloid-beta plaques in the brain to visualize amyloid pathology.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:17:21.158Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Positron emission tomography imaging of amyloid pathology in patients with cognitive impairment to assess for Alzheimer's disease pathology"},{"name":"Research and clinical assessment of amyloid-beta burden in neurodegenerative disease"}]},"trialDetails":[],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":42,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Amyvid"],"phase":"marketed","status":"active","brandName":"[18F]Florbetapir PET imaging","genericName":"[18F]Florbetapir PET imaging","companyName":"Institute for Neurodegenerative Disorders","companyId":"institute-for-neurodegenerative-disorders","modality":"Small molecule","firstApprovalDate":"","aiSummary":"[18F]Florbetapir is a positron emission tomography (PET) imaging agent that binds to amyloid-beta plaques in the brain to visualize amyloid pathology. Used for Positron emission tomography imaging of amyloid pathology in patients with cognitive impairment to assess for Alzheimer's disease pathology, Research and clinical assessment of amyloid-beta burden in neurodegenerative disease.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":false,"score":3}}