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It is used to prevent invasive pneumococcal disease in adults 18 years and older, including those with certain underlying medical conditions or HIV infection. The vaccine targets 15 serotypes of Streptococcus pneumoniae. It is a conjugate vaccine, which means it combines a weakened form of the bacteria with a carrier protein to stimulate an immune response. PCV15 is a valuable tool in preventing pneumococcal disease, particularly in high-risk populations. Its clinical differentiation lies in its ability to protect against a wide range of serotypes. 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The vaccine is formulated with a carrier protein to enhance immunogenicity and induce a strong immune response."},"_companyIR":{"url":"https://www.pfizer.com/investors","revenueRefs":[],"pipelineRefs":[]},"commercial":{"annualCostUS":"Generic pricing varies by manufacturer","genericStatus":"Generic — off-patent","peakSalesEstimate":"Not publicly reported"},"references":[{"id":1,"url":"https://clinicaltrials.gov/search?intr=15-valent-pneumococcal-conjugate-vaccine-pcv15","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=15-valent-pneumococcal-conjugate-vaccine-pcv15","fields":["publications"],"source":"PubMed/NCBI"},{"id":3,"url":"https://www.ebi.ac.uk/chembl/","fields":["molecular"],"source":"ChEMBL (EMBL-EBI)"},{"id":4,"url":"https://www.ema.europa.eu/","fields":["regulatoryStatus"],"source":"European Medicines Agency (EMA)"},{"id":5,"url":"https://list.essentialmeds.org/","fields":["regulatoryStatus"],"source":"WHO Essential 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