{"id":"14c-tak-906-oral-solution","_chembl":null,"modality":"Small molecule","_dailymed":null,"mechanism":{"target":"Dopamine D2/D3 receptors","explanation":"TAK-906 acts as a peripherally-restricted dopamine D2 and D3 receptor antagonist. By blocking these receptors, it modulates gastrointestinal motility and has been investigated for conditions involving gastric dysfunction. The [14C]-labeled version is used in metabolic studies.","oneSentence":"TAK-906 is a dopamine D2/D3 receptor antagonist that blocks dopaminergic signaling."},"_scrapedAt":"2026-03-28T05:44:43.151Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"_claudeStub":{"ts":1779123075,"model":"claude-sonnet-4-5-20250929"},"competitors":[{"name":"metoclopramide","brand":"Reglan","company":null,"rationale":"Dopamine antagonist used for gastroparesis and nausea"},{"name":"domperidone","brand":"Motilium","company":null,"rationale":"Peripheral dopamine antagonist for gastrointestinal motility disorders"}],"description":"[14C]-TAK-906 Oral Solution is a radiolabeled formulation of TAK-906 developed by Millennium Pharmaceuticals for Phase 1 clinical studies. The radiolabel enables tracking of drug metabolism and pharmacokinetics in human subjects to understand absorption, distribution, metabolism, and excretion pathways.","indications":{"approved":[{"status":"investigational","condition":"Gastroparesis","patientPopulation":"Adult patients"}]},"trialDetails":[],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_1","status":"active","brandName":"[14C]-TAK-906 Oral Solution","genericName":"[14C]-TAK-906 Oral Solution","companyName":"Millennium Pharmaceuticals, Inc.","companyId":"millennium-pharmaceuticals-inc","firstApprovalDate":"","aiSummary":"","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":1,"withResults":1},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":false,"score":2}}