{"id":"14c-etc-1002","_chembl":null,"modality":"Small molecule","_dailymed":null,"mechanism":{"target":"ATP citrate lyase","explanation":"ETC-1002 (bempedoic acid) inhibits ATP citrate lyase, an enzyme upstream of HMG-CoA reductase in the cholesterol biosynthesis pathway. The [14C] radiolabel allows researchers to track the drug's absorption, distribution, metabolism, and excretion in Phase 1 studies without altering the parent compound's biological activity.","oneSentence":"Radiolabeled tracer compound used to study the pharmacokinetics and metabolism of bempedoic acid."},"_scrapedAt":"2026-03-28T06:31:40.294Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"_claudeStub":{"ts":1779123058,"model":"claude-sonnet-4-5-20250929"},"description":"[14C-ETC-1002] is a radiolabeled version of ETC-1002 (bempedoic acid) developed by Esperion Therapeutics for Phase 1 clinical pharmacology studies. The carbon-14 labeling enables tracking of drug metabolism, distribution, and excretion pathways in early-stage human research.","indications":{"approved":[{"status":"investigational","condition":"Pharmacokinetic/metabolism studies","patientPopulation":"Healthy adult volunteers"}]},"trialDetails":[],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_1","status":"active","brandName":"[14C-ETC-1002]","genericName":"[14C-ETC-1002]","companyName":"Esperion Therapeutics, Inc.","companyId":"esperion-therapeutics-inc","firstApprovalDate":"","aiSummary":"14C-ETC-1002 is a small molecule inhibitor of the enzyme ATP-citrate synthase. It belongs to the drug class of inhibitors and has synonyms such as ACIDE BEMPEDOIQUE and BEMPEDOIC ACID.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":false,"score":2}}