{"id":"131i-tm-601","_chembl":null,"modality":"Small molecule","_dailymed":null,"mechanism":{"target":"Chlorotoxin-binding sites","explanation":"131I-TM-601 consists of a synthetic chlorotoxin-like peptide labeled with radioactive iodine-131. The peptide component binds selectively to certain tumor cells, particularly gliomas, allowing targeted delivery of beta radiation to malignant tissue while sparing normal cells.","oneSentence":"A radioiodinated synthetic peptide that binds to tumor cells for targeted delivery of radiation therapy."},"_scrapedAt":"2026-03-28T05:47:56.718Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"_claudeStub":{"ts":1779123333,"model":"claude-sonnet-4-5-20250929"},"competitors":[{"name":"carmustine","brand":"Gliadel","company":"Eisai","rationale":"Local therapy for malignant glioma"},{"name":"bevacizumab","brand":"Avastin","company":"Genentech","rationale":"Approved for recurrent glioblastoma"}],"description":"131I-TM-601 is an investigational radioiodinated peptide developed by TransMolecular for cancer imaging and therapy. The compound is in Phase 1 clinical development, exploring its potential use in oncology applications through targeted radiotherapy approaches.","indications":{"approved":[{"status":"investigational","condition":"Glioblastoma","patientPopulation":"Adult patients with recurrent or newly diagnosed disease"}]},"trialDetails":[{"nctId":"NCT00591058","phase":"PHASE1","title":"Safety and Dose-Finding Study of TM-601 in Adults With Recurrent Malignant Glioma","status":"UNKNOWN","sponsor":"TransMolecular","startDate":"2008-02","conditions":"Malignant Glioma, Glioblastoma Multiforme, GBM","enrollment":36},{"nctId":"NCT00683761","phase":"PHASE1, PHASE2","title":"A Study of 131I-TM601 in Adults With Recurrent Malignant Glioma","status":"UNKNOWN","sponsor":"TransMolecular","startDate":"2008-08","conditions":"Malignant Glioma, Glioblastoma Multiforme, GBM","enrollment":64},{"nctId":"NCT00733798","phase":"PHASE1, PHASE2","title":"A Safety and Efficacy Study of Intravenous 131I-TM601 in Adult Patients With Malignant Melanoma","status":"TERMINATED","sponsor":"TransMolecular","startDate":"","conditions":"Melanoma, Malignant Melanoma, Metastatic Melanoma","enrollment":58},{"nctId":"NCT00114309","phase":"PHASE2","title":"131-I-TM-601 Study in Adults With Recurrent High-Grade Glioma","status":"UNKNOWN","sponsor":"TransMolecular","startDate":"2004-11","conditions":"Malignant Glioma, Glioblastoma Multiforme, GBM","enrollment":66},{"nctId":"NCT00379132","phase":"PHASE1","title":"131-I-TM-601 Study in Adults With Solid Tumors","status":"COMPLETED","sponsor":"TransMolecular","startDate":"2006-08","conditions":"Breast Cancer, Non-Small Cell Lung Cancer, Melanoma","enrollment":60},{"nctId":"NCT00040573","phase":"PHASE1, PHASE2","title":"Safety and Tolerability Study of 131I-TM-601 to Treat Adult Patients With Recurrent Glioma.","status":"COMPLETED","sponsor":"TransMolecular","startDate":"2002-06","conditions":"Glioma, Brain Neoplasm","enrollment":18}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":4,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_1","status":"active","brandName":"131I-TM-601","genericName":"131I-TM-601","companyName":"TransMolecular","companyId":"transmolecular","firstApprovalDate":"","aiSummary":"131I-TM-601 is a treatment being studied for glioma, brain neoplasm, malignant glioma, glioblastoma multiforme, and GBM. It is administered intracavitary in a Phase I/II study to assess its safety and tolerability in adult patients with recurrent high-grade glioma.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":true,"score":3}}