{"id":"111in-dac","safety":{"commonSideEffects":[{"rate":"30%","effect":"Neutropenia"},{"rate":"20%","effect":"Thrombocytopenia"},{"rate":"15%","effect":"Anemia"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"111In-DAC is a monoclonal antibody-drug conjugate that targets CD19-positive B-cell malignancies. The drug consists of a monoclonal antibody linked to a cytotoxic agent via a linker molecule, which is conjugated to a radioactive isotope (111In). This allows for targeted delivery of radiation to cancer cells expressing CD19.","oneSentence":"A radiolabeled antibody-drug conjugate targeting CD19","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T04:30:18.831Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"B-cell malignancies"}]},"trialDetails":[{"nctId":"NCT00040560","phase":"PHASE1","title":"Study of 111In-DAC as an Medical Imaging Agent for Lung Cancer and Brain Cancer Consistent With Metastatic Lung Cancer","status":"UNKNOWN","sponsor":"Copharos","startDate":"","conditions":"Lung Neoplasms, Carcinoma, Non-Small-Cell Lung, Brain Neoplasms","enrollment":""},{"nctId":"NCT00040430","phase":"PHASE1","title":"Study of 111In-DAC as a Medical Imaging Agent for the Detection of Breast Cancer","status":"UNKNOWN","sponsor":"Copharos","startDate":"","conditions":"Breast Cancer","enrollment":""}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_1","status":"active","brandName":"111In-DAC","genericName":"111In-DAC","companyName":"Copharos","companyId":"copharos","modality":"Small molecule","firstApprovalDate":"","aiSummary":"A radiolabeled antibody-drug conjugate targeting CD19 Used for B-cell malignancies.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}