{"disease":{"id":"valve-replacement","name":"valve replacement"},"drugs":{"marketed":[],"pipeline":[],"offLabel":[],"totalMarketed":0,"totalPipeline":0},"trials":{"data":[{"nct_id":"NCT07267117","title":"Cohort Observing Mechanisms, Progression and Sequelae of Valvular Heart Disease","phase":"","overall_status":"RECRUITING","enrollment_count":10000,"lead_sponsor_name":"Second Affiliated Hospital, School of Medicine, Zhejiang University","has_results":false},{"nct_id":"NCT07489313","title":"Association of Prosthesis Types for Aortic or Mitral Valve Replacement With Long-term Risk of Mental Disorders","phase":"","overall_status":"COMPLETED","enrollment_count":4761,"lead_sponsor_name":"Samsung Medical Center","has_results":false},{"nct_id":"NCT06782620","title":"Association Between Surgical Aortic Valve Replacement and Long-term Outcomes in 50 to 65-year-olds","phase":"","overall_status":"COMPLETED","enrollment_count":3761,"lead_sponsor_name":"Medical University of Vienna","has_results":false},{"nct_id":"NCT07168889","title":"The Choice of Mitral Valve Surgery Type and Mid-term Outcomes in Patients up to 70-years: Results of the AUTHEARTVISIT Study","phase":"","overall_status":"COMPLETED","enrollment_count":3520,"lead_sponsor_name":"Alissa Florian","has_results":false},{"nct_id":"NCT03636295","title":"Low INR to Minimize Bleeding With Mechanical Valves Trial","phase":"PHASE3","overall_status":"RECRUITING","enrollment_count":2625,"lead_sponsor_name":"Population Health Research Institute","has_results":false},{"nct_id":"NCT06000943","title":"Ischemic And Bleeding Risk Assessment After TAVR","phase":"","overall_status":"RECRUITING","enrollment_count":2500,"lead_sponsor_name":"Niguarda Hospital","has_results":false},{"nct_id":"NCT03885570","title":"Blood Transfusion Management in Patients With Mitral Valve Replacement in China","phase":"","overall_status":"UNKNOWN","enrollment_count":2000,"lead_sponsor_name":"The Third Xiangya Hospital of Central South University","has_results":false},{"nct_id":"NCT04139616","title":"Prospective Validation of a Pre-Specified Algorithm for the Management of Conduction Disturbances Following TAVR","phase":"","overall_status":"RECRUITING","enrollment_count":2000,"lead_sponsor_name":"Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Quebec","has_results":false},{"nct_id":"NCT02556203","title":"Global Study Comparing a rivAroxaban-based Antithrombotic Strategy to an antipLatelet-based Strategy After Transcatheter aortIc vaLve rEplacement to Optimize Clinical Outcomes","phase":"PHASE3","overall_status":"TERMINATED","enrollment_count":1653,"lead_sponsor_name":"Bayer","has_results":true},{"nct_id":"NCT02664649","title":"Anti-Thrombotic Strategy After Trans-Aortic Valve Implantation for Aortic Stenosis","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":1510,"lead_sponsor_name":"Assistance Publique - Hôpitaux de Paris","has_results":false},{"nct_id":"NCT05283356","title":"Single Antiplatelet Treatment With Ticagrelor or Aspirin After Transcatheter Aortic Valve Implantation","phase":"PHASE4","overall_status":"UNKNOWN","enrollment_count":1206,"lead_sponsor_name":"Fundacin Biomedica Galicia Sur","has_results":false},{"nct_id":"NCT07431762","title":"Comparison of Anti-Thrombotic Treatments Between Aspirin and Warfarin During Initial Six Months After Bioprpsthetic Heart Valve Replacement","phase":"PHASE4","overall_status":"NOT_YET_RECRUITING","enrollment_count":1058,"lead_sponsor_name":"Asan Medical Center","has_results":false},{"nct_id":"NCT05235555","title":"EffecTAVI Registry","phase":"","overall_status":"RECRUITING","enrollment_count":1000,"lead_sponsor_name":"Federico II University","has_results":false},{"nct_id":"NCT06403839","title":"Impact of Preoperative Dental Screening in Reducing Infective Endocarditis Risk in Surgical Valve Replacement Patients","phase":"","overall_status":"RECRUITING","enrollment_count":1000,"lead_sponsor_name":"Odense University Hospital","has_results":false},{"nct_id":"NCT06697249","title":"Feasibility of Valve-in-Root Transcatheter Aortic Valve Implantation in 363 Patients After Aortic Root Replacement and Repair","phase":"","overall_status":"COMPLETED","enrollment_count":760,"lead_sponsor_name":"Alicja Zientara","has_results":false},{"nct_id":"NCT07107568","title":"Assessment of Coronary Artery Disease Before Transcatheter Aortic Valve Replacement: A Randomized, Multicenter, Non-Inferiority Trial","phase":"NA","overall_status":"RECRUITING","enrollment_count":700,"lead_sponsor_name":"Medical University Innsbruck","has_results":false},{"nct_id":"NCT01368666","title":"Safety and Effectiveness Study of Perceval S Valve for Extended CE Mark","phase":"NA","overall_status":"TERMINATED","enrollment_count":658,"lead_sponsor_name":"Corcym S.r.l","has_results":false},{"nct_id":"NCT05375474","title":"Antithrombotic Strategy Based on Clinical Events and 4D-CT for Patients After TAVR","phase":"PHASE4","overall_status":"UNKNOWN","enrollment_count":650,"lead_sponsor_name":"China National Center for Cardiovascular Diseases","has_results":false},{"nct_id":"NCT07129421","title":"Evaluation of Safety and Effectiveness of the EMBLOK EPS Compared With No Cerebral Embolic Protection During TAVR","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":560,"lead_sponsor_name":"Emblok, Inc.","has_results":false},{"nct_id":"NCT06559332","title":"Coronary Artery Disease Assessment Strategies in TAVI Patients","phase":"NA","overall_status":"RECRUITING","enrollment_count":546,"lead_sponsor_name":"Insel Gruppe AG, University Hospital Bern","has_results":false},{"nct_id":"NCT05295628","title":"Evaluation of Safety and Effectiveness of the EMBLOK EPS During TAVR","phase":"NA","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":532,"lead_sponsor_name":"Emblok, Inc.","has_results":false},{"nct_id":"NCT06953206","title":"Prospective, Long-term Evaluation of the SAPIEN 3 Ultra RESILIA Valve","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":500,"lead_sponsor_name":"Institut für Pharmakologie und Präventive Medizin","has_results":false},{"nct_id":"NCT06857201","title":"RAFT-TAVR PACE: LBBAP Vs. RVP Post-TAVR in Patients Requiring PPI","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":430,"lead_sponsor_name":"London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's","has_results":false},{"nct_id":"NCT03346044","title":"Medtronic's MOSAIC Bioprosthesis Versus Baxter Carpentier-Edwards SAV Porcine Valve","phase":"NA","overall_status":"COMPLETED","enrollment_count":428,"lead_sponsor_name":"University Hospital Plymouth NHS Trust","has_results":false},{"nct_id":"NCT04982406","title":"Transcatheter Aortic Valve Replacement (TAVR) Effects on Cardiac Conduction System","phase":"","overall_status":"COMPLETED","enrollment_count":409,"lead_sponsor_name":"Beth Israel Deaconess Medical Center","has_results":false},{"nct_id":"NCT05657912","title":"Cara CDRS (Conduction Disturbance Risk Score) 1.0","phase":"","overall_status":"COMPLETED","enrollment_count":355,"lead_sponsor_name":"Cara Medical Ltd","has_results":false},{"nct_id":"NCT06917586","title":"Mosaic Mitral Valve: Long-Term Outcomes in Patients Under 65","phase":"","overall_status":"RECRUITING","enrollment_count":300,"lead_sponsor_name":"Michael Moront","has_results":false},{"nct_id":"NCT03686527","title":"Myocardial Function of the Setonis Aortic Valve Before and Beyond Valve Replacement","phase":"","overall_status":"COMPLETED","enrollment_count":277,"lead_sponsor_name":"Rennes University Hospital","has_results":false},{"nct_id":"NCT02400489","title":"Clinical Study to Evaluate the Performance of Perimount Heart Valve in Chinese Patients","phase":"","overall_status":"COMPLETED","enrollment_count":265,"lead_sponsor_name":"Edwards Lifesciences","has_results":false},{"nct_id":"NCT07370467","title":"Transcatheter Mitral and Tricuspid Interventions: a Cardiac Magnetic Resonance Study","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":250,"lead_sponsor_name":"Centro Cardiologico Monzino","has_results":false},{"nct_id":"NCT01627691","title":"REPRISE II: REpositionable Percutaneous Replacement of Stenotic Aortic Valve Through Implantation of Lotus™ Valve System","phase":"NA","overall_status":"COMPLETED","enrollment_count":250,"lead_sponsor_name":"Boston Scientific Corporation","has_results":true},{"nct_id":"NCT05654792","title":"Prognostic Factors in NOP-LBBB After TAVI","phase":"","overall_status":"UNKNOWN","enrollment_count":230,"lead_sponsor_name":"Central Hospital, Nancy, France","has_results":false},{"nct_id":"NCT02523066","title":"Clinical Study to Evaluate the Performance of Magna Ease Heart Valve in Chinese Patients","phase":"","overall_status":"TERMINATED","enrollment_count":215,"lead_sponsor_name":"Edwards Lifesciences","has_results":false},{"nct_id":"NCT06212050","title":"Feasibility, Safety, and Effectiveness of the ACURATE neo2 Transcatheter Heart Valve for Severe Bicuspid Aortic Stenosis","phase":"","overall_status":"ENROLLING_BY_INVITATION","enrollment_count":200,"lead_sponsor_name":"National University of Ireland, Galway, Ireland","has_results":false},{"nct_id":"NCT04649190","title":"Post-TAVI Coronary Access Study","phase":"","overall_status":"COMPLETED","enrollment_count":200,"lead_sponsor_name":"Sheba Medical Center","has_results":false},{"nct_id":"NCT05259241","title":"ADAPT Transcatheter Aortic Valve Intervention (TAVI & Chronic Total Occlusion Percutaneous Coronary Intervention (CTO PCI)","phase":"NA","overall_status":"UNKNOWN","enrollment_count":200,"lead_sponsor_name":"Erasmus Medical Center","has_results":false},{"nct_id":"NCT03522454","title":"The PERFORM-TAVR Trial","phase":"NA","overall_status":"UNKNOWN","enrollment_count":200,"lead_sponsor_name":"Jewish General Hospital","has_results":false},{"nct_id":"NCT07455292","title":"Phenotyping Left Ventricle Failure With Hemodynamic Biomarkers From 4D Flow Magnetic Resonance Imaging","phase":"NA","overall_status":"RECRUITING","enrollment_count":190,"lead_sponsor_name":"IRCCS Policlinico S. Donato","has_results":false},{"nct_id":"NCT04107038","title":"Monitored Anesthesia Care vs. General Anesthesia for Transcatheter Aortic Valve Replacement","phase":"NA","overall_status":"COMPLETED","enrollment_count":170,"lead_sponsor_name":"Medical University of South Carolina","has_results":false},{"nct_id":"NCT02735902","title":"Anticoagulation Alone Versus Anticoagulation and Aspirin Following Transcatheter Aortic Valve Interventions (1:1)","phase":"PHASE4","overall_status":"COMPLETED","enrollment_count":170,"lead_sponsor_name":"Centre Hospitalier Universitaire de Nīmes","has_results":false},{"nct_id":"NCT05758701","title":"CT TAVR Abdomen Study","phase":"PHASE4","overall_status":"RECRUITING","enrollment_count":164,"lead_sponsor_name":"University of Maryland, Baltimore","has_results":false},{"nct_id":"NCT04012060","title":"Patient Reported Health-Related Quality of Life After Limited Access and Conventional Aortic Valve Replacement","phase":"NA","overall_status":"COMPLETED","enrollment_count":161,"lead_sponsor_name":"St. Antonius Hospital","has_results":false},{"nct_id":"NCT03801460","title":"Physiological Reconditioning Program Administered Remotely in Patients Undergoing Transcatheter Aortic Valve Replacement: A Pilot Study","phase":"NA","overall_status":"UNKNOWN","enrollment_count":160,"lead_sponsor_name":"Unity Health Toronto","has_results":false},{"nct_id":"NCT07123480","title":"The Role of 4 Different Consent Approaches on a Pilot Study to Increase Cardiac Rehabilitation Attendance","phase":"NA","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":160,"lead_sponsor_name":"Baystate Medical Center","has_results":false},{"nct_id":"NCT05217888","title":"The Sentinel Registry","phase":"","overall_status":"COMPLETED","enrollment_count":158,"lead_sponsor_name":"Duk-Woo Park, MD","has_results":false},{"nct_id":"NCT06040398","title":"The JUMPSTART Program: Encouraging Early Mobilization and Optimizing Recovery of TAVR Patients' Post-hospital Discharge","phase":"","overall_status":"UNKNOWN","enrollment_count":150,"lead_sponsor_name":"Hamilton Health Sciences Corporation","has_results":false},{"nct_id":"NCT07365345","title":"Frequency of Electrical Acupoint Stimulation on Hypotension in TAVR Patients","phase":"NA","overall_status":"RECRUITING","enrollment_count":150,"lead_sponsor_name":"Air Force Military Medical University, China","has_results":false},{"nct_id":"NCT06420830","title":"Valve Performance of the SAPIEN 3 Ultra RESILIA Valve: A Prospective Registry With Central Echocardiography Analysis.","phase":"","overall_status":"RECRUITING","enrollment_count":150,"lead_sponsor_name":"Institut universitaire de cardiologie et de pneumologie de Québec, University Laval","has_results":false},{"nct_id":"NCT05024942","title":"LUS in Aortic Stenosis Patients Undergoing TAVR","phase":"","overall_status":"UNKNOWN","enrollment_count":150,"lead_sponsor_name":"Catholic University of the Sacred Heart","has_results":false},{"nct_id":"NCT04652375","title":"Outcomes After Albumin Vs Lactated Ringer's Solution in CABG and AVR Procedures","phase":"NA","overall_status":"COMPLETED","enrollment_count":131,"lead_sponsor_name":"Yale University","has_results":false}],"total":50},"guidelines":[],"source":"Drug Landscape verified database"}