{"disease":{"id":"uterine-fibroids","name":"Uterine fibroids","therapeutic_area":"","data":{},"enrichment_level":0,"last_enriched_at":null,"visit_count":0,"created_at":"2026-04-19T18:31:21.150Z","updated_at":"2026-04-19T18:39:44.960Z","meddra_pt":null,"meddra_code":null,"icd10_codes":null,"synonyms":[],"prevalence_global":null,"prevalence_us":null,"marketed_drug_count":3,"pipeline_drug_count":1,"trial_count":0},"drugs":{"marketed":[{"drug_id":"relugolix","indication_name":"Uterine fibroids","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Orgovyx","generic_name":"relugolix","company_name":"MYOVANT SCIENCES","drug_phase":"marketed","molecular_target":"Gonadotropin-releasing hormone receptor","drug_class":"Gonadotropin Releasing Hormone Receptor Antagonist [EPC]","quality_score":72,"revenue":"421","mechanism":"Relugolix is a nonpeptide GnRH receptor antagonist that competitively binds to pituitary GnRH receptors."},{"drug_id":"linzagolix","indication_name":"Uterine fibroids","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Yselty","generic_name":"LINZAGOLIX","company_name":"Obseva Ireland Ltd","drug_phase":"marketed","molecular_target":"Gonadotropin-releasing hormone receptor","drug_class":"","quality_score":35,"revenue":null,"mechanism":""},{"drug_id":"norethindrone-acetate","indication_name":"Uterine fibroids","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Aygestin","generic_name":"NORETHINDRONE ACETATE","company_name":"Duramed Res","drug_phase":"marketed","molecular_target":"Progesterone receptor","drug_class":"Estrogen [EPC]","quality_score":46,"revenue":null,"mechanism":""}],"pipeline":[{"drug_id":"norethindrone","indication_name":"Uterine fibroids","indication_type":"pipeline","phase":"Phase 3","line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"NORETHINDRONE","company_name":"","drug_phase":"marketed","molecular_target":"Progesterone receptor","drug_class":"Estrogen [EPC]","quality_score":10,"revenue":null,"mechanism":""}],"offLabel":[],"totalMarketed":3,"totalPipeline":1},"trials":{"data":[{"nct_id":"NCT07177534","title":"Prospective Validation Study of a Uterine Fibroid-Related Infertility Prediction Model","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":7084,"lead_sponsor_name":"Tongji Hospital","has_results":false},{"nct_id":"NCT07137299","title":"POPQ Associated With Total Laparoscopic Hysterectomy","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":2000,"lead_sponsor_name":"Medical University of Silesia","has_results":false},{"nct_id":"NCT00339547","title":"Risk Factors for Uterine Fibroids: A Case Control Study","phase":"","overall_status":"COMPLETED","enrollment_count":1529,"lead_sponsor_name":"National Institute of Environmental Health Sciences (NIEHS)","has_results":false},{"nct_id":"NCT02748460","title":"Non-interventional Study to Evaluate Long Term Safety, Prescription Management Patterns of Esmya in a Long Term Setting","phase":"","overall_status":"COMPLETED","enrollment_count":1527,"lead_sponsor_name":"PregLem SA","has_results":false},{"nct_id":"NCT03194646","title":"Assess Safety and Efficacy of Vilaprisan in Subjects With Uterine Fibroids","phase":"PHASE3","overall_status":"TERMINATED","enrollment_count":1272,"lead_sponsor_name":"Bayer","has_results":true},{"nct_id":"NCT03586947","title":"Association Between Vitamin D and the Risk of Uterine Fibroids","phase":"NA","overall_status":"UNKNOWN","enrollment_count":1160,"lead_sponsor_name":"Second Affiliated Hospital of Wenzhou Medical University","has_results":false},{"nct_id":"NCT07480785","title":"TEAS Combined With Triple Antiemetic Drugs to Prevent PONV in High-Risk Patients","phase":"NA","overall_status":"RECRUITING","enrollment_count":780,"lead_sponsor_name":"Zhejiang University","has_results":false},{"nct_id":"NCT03240523","title":"A Study to Assess Safety and Efficacy of Vilaprisan in Subjects With Uterine Fibroids","phase":"PHASE3","overall_status":"TERMINATED","enrollment_count":766,"lead_sponsor_name":"Bayer","has_results":false},{"nct_id":"NCT04400942","title":"Predictive Factors for Complete Myoma Resection During Hysteroscopic Myomectomy","phase":"","overall_status":"UNKNOWN","enrollment_count":600,"lead_sponsor_name":"Ospedale Policlinico San Martino","has_results":false},{"nct_id":"NCT03070899","title":"Efficacy and Safety of OBE2109 in Subjects With Heavy Menstrual Bleeding Associated With Uterine Fibroids","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":526,"lead_sponsor_name":"ObsEva SA","has_results":false},{"nct_id":"NCT03070951","title":"Efficacy and Safety of OBE2109 in Subjects With Heavy Menstrual Bleeding Associated With Uterine Fibroids","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":511,"lead_sponsor_name":"ObsEva SA","has_results":false},{"nct_id":"NCT03271489","title":"Long-Term Safety Study of Elagolix in Combination With Estradiol/Norethindrone Acetate for the Management of Heavy Menstrual Bleeding Associated With Uterine Fibroids in Premenopausal Women","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":478,"lead_sponsor_name":"AbbVie","has_results":true},{"nct_id":"NCT02925494","title":"An Extension Study to Evaluate the Efficacy and Safety of Elagolix in Premenopausal Women With Heavy Menstrual Bleeding Associated With Uterine Fibroids","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":433,"lead_sponsor_name":"AbbVie","has_results":true},{"nct_id":"NCT02654054","title":"Efficacy and Safety of Elagolix in Combination With Estradiol/Norethindrone Acetate for the Management of Heavy Menstrual Bleeding Associated With Uterine Fibroids in Premenopausal Women","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":413,"lead_sponsor_name":"AbbVie","has_results":true},{"nct_id":"NCT02691494","title":"Efficacy and Safety of Elagolix in Combination With Estradiol/Norethindrone Acetate for the Management of Heavy Menstrual Bleeding Associated With Uterine Fibroids in Premenopausal Women (Replicate Study)","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":378,"lead_sponsor_name":"AbbVie","has_results":true},{"nct_id":"NCT05442827","title":"A Phase II/III Study of Efficacy and Safety of SHR7280 Tablets in Subjects With Menorrhagia With Uterine Fibroids","phase":"PHASE2, PHASE3","overall_status":"RECRUITING","enrollment_count":357,"lead_sponsor_name":"Jiangsu HengRui Medicine Co., Ltd.","has_results":false},{"nct_id":"NCT06055114","title":"Study on Vaginal Microecology and Cervical Local Immune Function in Patients With Uterine Fibroids of Childbearing Age","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":300,"lead_sponsor_name":"Lin Yuan","has_results":false},{"nct_id":"NCT05440383","title":"A Clinical Study of KLH-2109 in Uterine Fibroids Patient With Menorrhagia","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":287,"lead_sponsor_name":"Kissei Pharmaceutical Co., Ltd.","has_results":false},{"nct_id":"NCT02655237","title":"A Phase 3 Study to Evaluate the Efficacy and Safety of Relugolix (TAK-385) 40 mg Compared With Leuprorelin in the Treatment of Uterine Fibroids","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":281,"lead_sponsor_name":"Takeda","has_results":true},{"nct_id":"NCT07378098","title":"to Evaluate the Efficacy and Safety of KLH-2109 in Patients With Uterine Fibroids and Menorrhagia","phase":"PHASE3","overall_status":"RECRUITING","enrollment_count":254,"lead_sponsor_name":"JW Pharmaceutical","has_results":false},{"nct_id":"NCT06845982","title":"Anatomopathological Evaluation of a New Ultrasound-guided Transuterine Vaginal Biopsy Technique in Uterine Fibromatous Disease","phase":"NA","overall_status":"RECRUITING","enrollment_count":250,"lead_sponsor_name":"Assistance Publique Hopitaux De Marseille","has_results":false},{"nct_id":"NCT07230444","title":"Artificial Intelligence for the Intra-procedural Assessment of Uterine Artery Embolization","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":250,"lead_sponsor_name":"Emanuele Barabino","has_results":false},{"nct_id":"NCT07384468","title":"Ultrasound-Guided Stellate Ganglion Block Plus Propofol for Perimenopausal Insomnia With Anxiety","phase":"NA","overall_status":"COMPLETED","enrollment_count":233,"lead_sponsor_name":"Xiaochen Ji","has_results":false},{"nct_id":"NCT03751124","title":"Study of Relugolix With Estradiol and Norethindrone Acetate in Women With Heavy Menstrual Bleeding Associated With Uterine Fibroids","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":229,"lead_sponsor_name":"Myovant Sciences GmbH","has_results":true},{"nct_id":"NCT07186257","title":"Impact of Uterine Leiomyoma Location on Uterine Artery Doppler Velocimetry","phase":"","overall_status":"COMPLETED","enrollment_count":185,"lead_sponsor_name":"Bakirkoy Dr. Sadi Konuk Research and Training Hospital","has_results":false},{"nct_id":"NCT03476928","title":"A Study to Assess the Safety and Efficacy of Vilaprisan in Japanese Subjects With Uterine Fibroids and Heavy Menstrual Bleeding","phase":"PHASE3","overall_status":"TERMINATED","enrollment_count":153,"lead_sponsor_name":"Bayer","has_results":false},{"nct_id":"NCT07402369","title":"Phase II Study of CMS-D002 Capsule for Uterine Fibroids With Menorrhagia","phase":"PHASE2","overall_status":"RECRUITING","enrollment_count":120,"lead_sponsor_name":"Shenzhen Kangzhe Biotechnology Co., Ltd.","has_results":false},{"nct_id":"NCT06671548","title":"Efficacy & Safety Study of Relugolix in Women With Heavy Menstrual Bleeding Associated With Uterine Fibroids","phase":"PHASE3","overall_status":"RECRUITING","enrollment_count":120,"lead_sponsor_name":"Qilu Pharmaceutical Co., Ltd.","has_results":false},{"nct_id":"NCT06692335","title":"HIFU Versus Myomectomy for the Treatment of Symptomatic Uterine Fibroids","phase":"NA","overall_status":"RECRUITING","enrollment_count":112,"lead_sponsor_name":"Chinese University of Hong Kong","has_results":false},{"nct_id":"NCT03400956","title":"Assess Safety and Efficacy of Vilaprisan in Subjects With Uterine Fibroids (ASTEROID 4)","phase":"PHASE3","overall_status":"TERMINATED","enrollment_count":103,"lead_sponsor_name":"Bayer","has_results":true},{"nct_id":"NCT03400943","title":"Assess Safety and Efficacy of Vilaprisan in Subjects With Uterine Fibroids (ASTEROID 3)","phase":"PHASE3","overall_status":"TERMINATED","enrollment_count":93,"lead_sponsor_name":"Bayer","has_results":true},{"nct_id":"NCT06768086","title":"Preoperative Administration of EGCG, Vitamin D and DCI Prior Hysteroscopic Myomectomy","phase":"","overall_status":"COMPLETED","enrollment_count":90,"lead_sponsor_name":"Centro di Ricerca Clinica Salentino","has_results":false},{"nct_id":"NCT05445167","title":"A Clinical Study of KLH-2109 in Uterine Fibroids Patient With Menorrhagia and Pain","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":89,"lead_sponsor_name":"Kissei Pharmaceutical Co., Ltd.","has_results":false},{"nct_id":"NCT03886220","title":"A Study to Evaluate the Safety and Efficacy of Elagolix for the Management of Heavy Menstrual Bleeding Associated With Uterine Fibroids in Premenopausal Women","phase":"PHASE4","overall_status":"COMPLETED","enrollment_count":82,"lead_sponsor_name":"AbbVie","has_results":true},{"nct_id":"NCT04762316","title":"Composition for Treating Uterine Fibroid (SB-UF)","phase":"PHASE4","overall_status":"COMPLETED","enrollment_count":66,"lead_sponsor_name":"Trieu, Nguyen Thi, M.D.","has_results":false},{"nct_id":"NCT02655224","title":"A Placebo-Controlled, Phase 3 Study of Relugolix (TAK-385) 40 mg in the Treatment of Pain Symptoms Associated With Uterine Fibroids","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":65,"lead_sponsor_name":"Takeda","has_results":true},{"nct_id":"NCT00958334","title":"Extension Study of Proellex in Women Who Have Previously Completed Study ZPU 003","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":65,"lead_sponsor_name":"Repros Therapeutics Inc.","has_results":true},{"nct_id":"NCT06828419","title":"A Clinical Study on the Feasibility and Safety of Abdominal Endoscopic Single-port Surgery System to Assist Gynecological Day Surgery","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":63,"lead_sponsor_name":"Second Affiliated Hospital of Wenzhou Medical University","has_results":false},{"nct_id":"NCT05448365","title":"Vitamin D, Epigallocatechin Gallate, D-chiro-inositol and Vitamin B6 in Uterine Fibroid","phase":"NA","overall_status":"RECRUITING","enrollment_count":60,"lead_sponsor_name":"Lo.Li.Pharma s.r.l","has_results":false},{"nct_id":"NCT07352761","title":"Bilateral Uterine Artery Occlusion During Laparoscopic Myomectomy","phase":"NA","overall_status":"RECRUITING","enrollment_count":60,"lead_sponsor_name":"Alexandria University","has_results":false},{"nct_id":"NCT07501676","title":"Transmucosal Uterosacral Electrical Stimulation for Pelvic Pain Relief","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":60,"lead_sponsor_name":"Weill Medical College of Cornell University","has_results":false},{"nct_id":"NCT06640738","title":"Investigating the Optimal Remifentanil and Dexmedetomidine Concentration for Uterine Fibroid Ablation","phase":"PHASE4","overall_status":"NOT_YET_RECRUITING","enrollment_count":60,"lead_sponsor_name":"Kaohsiung Medical University","has_results":false},{"nct_id":"NCT07046949","title":"Anterior Quadratus Lumborum Block as a Component of Multimodal Analgesia for Abdominal Hysterectomies","phase":"NA","overall_status":"COMPLETED","enrollment_count":56,"lead_sponsor_name":"Yuri Semenyuk Rivne Regional Clinical Hospital","has_results":false},{"nct_id":"NCT04091529","title":"Tailored Radiofrequency Ablation of Uterine Myomas","phase":"NA","overall_status":"COMPLETED","enrollment_count":54,"lead_sponsor_name":"International Evangelical Hospital","has_results":false},{"nct_id":"NCT05078307","title":"Evaluation of a Hysteroscopic Method With Vaporization in the Hysteroscopic Treatment of Submucosal Uterine Fibroids","phase":"NA","overall_status":"UNKNOWN","enrollment_count":54,"lead_sponsor_name":"Assistance Publique Hopitaux De Marseille","has_results":false},{"nct_id":"NCT06697444","title":"Risk Factors and Disorders Linked to Uterine Adenomyosis on MRI in Reproductive-Age Women","phase":"","overall_status":"COMPLETED","enrollment_count":50,"lead_sponsor_name":"Mashhad University of Medical Sciences","has_results":false},{"nct_id":"NCT02301897","title":"A Multi-Center, Parallel Design, Randomized, Double-Blind Study to Evaluate the Safety and Efficacy of 6 and 12 mg Proellex® (Telapristone Acetate) Administered Orally in the Treatment of Premenopausal Women With Confirmed Symptomatic Uterine Fibroids","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":43,"lead_sponsor_name":"Repros Therapeutics Inc.","has_results":true},{"nct_id":"NCT02323646","title":"Safety and Efficacy of Telapristone Acetate (Proellex®) Administered Vaginally for the Treatment of Uterine Fibroids","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":42,"lead_sponsor_name":"Repros Therapeutics Inc.","has_results":true},{"nct_id":"NCT04177693","title":"Pharmacokinetics and Hepatic Safety of EGCG","phase":"PHASE1","overall_status":"COMPLETED","enrollment_count":39,"lead_sponsor_name":"Yale University","has_results":true},{"nct_id":"NCT02844920","title":"Evaluation of Uterine Patency Following Sonography-guided Transcervical Ablation of Fibroids","phase":"","overall_status":"COMPLETED","enrollment_count":37,"lead_sponsor_name":"Gynesonics","has_results":true}],"total":50},"guidelines":[],"source":"Drug Landscape verified database"}