{"disease":{"id":"urinary-frequency","name":"Urinary frequency","therapeutic_area":"","data":{},"enrichment_level":0,"last_enriched_at":null,"visit_count":0,"created_at":"2026-04-19T18:31:21.150Z","updated_at":"2026-04-19T18:39:44.960Z","meddra_pt":null,"meddra_code":null,"icd10_codes":null,"synonyms":[],"prevalence_global":null,"prevalence_us":null,"marketed_drug_count":1,"pipeline_drug_count":0,"trial_count":0},"drugs":{"marketed":[{"drug_id":"tolterodine","indication_name":"Increased Urinary Frequency","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Detrol","generic_name":"TOLTERODINE","company_name":"Upjohn","drug_phase":"marketed","molecular_target":"Muscarinic acetylcholine receptor M1","drug_class":"Cholinergic Muscarinic Antagonist","quality_score":63,"revenue":null,"mechanism":"Detrol works by blocking the action of a chemical called acetylcholine at the muscarinic receptors in the bladder muscle."},{"drug_id":"botulinum-toxin-type-a","indication_name":"Urinary frequency","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Nuceiva","generic_name":"BOTULINUM TOXIN TYPE A","company_name":"GlaxoSmithKline K.K.","drug_phase":"marketed","molecular_target":"Synaptosomal-associated protein 25","drug_class":"Acetylcholine Release Inhibitor [EPC]","quality_score":10,"revenue":null,"mechanism":"Nuceiva works by blocking the release of acetylcholine, a neurotransmitter that transmits signals from nerve cells to muscles, thereby reducing muscle spasms and contractions."},{"drug_id":"trospium","indication_name":"Increased Urinary Frequency","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Sanctura","generic_name":"TROSPIUM","company_name":"AbbVie","drug_phase":"marketed","molecular_target":"Muscarinic acetylcholine receptor M3","drug_class":"Cholinergic Muscarinic Antagonist","quality_score":63,"revenue":null,"mechanism":"Sanctura works by blocking the action of a chemical called acetylcholine at the M3 receptor in the bladder muscle, reducing muscle contractions and urgency."},{"drug_id":"vesicare","indication_name":"Increased Urinary Frequency","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Vesicare","company_name":"University of California, Irvine","drug_phase":"discontinued","molecular_target":"Muscarinic acetylcholine receptor M1, Muscarinic acetylcholine receptor M2, Muscarinic acetylcholine receptor M3","drug_class":"","quality_score":null,"revenue":null,"mechanism":""},{"drug_id":"butacaine","indication_name":"Increased Urinary Frequency","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Butyn","generic_name":"BUTACAINE","company_name":"","drug_phase":"marketed","molecular_target":"Sodium channel alpha subunits; brain (Types I, II, III)","drug_class":"butacaine","quality_score":23,"revenue":null,"mechanism":""},{"drug_id":"toviaz","indication_name":"Increased Urinary Frequency","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Toviaz","generic_name":"Fesoterodine Fumarate","company_name":"Pfizer","drug_phase":"marketed","molecular_target":"Muscarinic acetylcholine receptor M2","drug_class":"fesoterodine","quality_score":10,"revenue":null,"mechanism":""},{"drug_id":"fesoterodine","indication_name":"Increased Urinary Frequency","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Toviaz","generic_name":"FESOTERODINE","company_name":"Pfizer","drug_phase":"marketed","molecular_target":"Muscarinic acetylcholine receptor M2","drug_class":"fesoterodine","quality_score":44,"revenue":null,"mechanism":""},{"drug_id":"solifenacin","indication_name":"Increased Urinary Frequency","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Vesicare","generic_name":"SOLIFENACIN","company_name":"Astellas Pharma","drug_phase":"marketed","molecular_target":"Muscarinic acetylcholine receptor M1","drug_class":"Cholinergic Muscarinic Antagonist","quality_score":80,"revenue":null,"mechanism":"Vesicare works by blocking the action of a chemical called acetylcholine at the muscarinic receptors in the bladder muscle, reducing muscle contractions and urgency."},{"drug_id":"flavoxate","indication_name":"Increased Urinary Frequency","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Urispas","generic_name":"FLAVOXATE","company_name":"","drug_phase":"marketed","molecular_target":"Potassium voltage-gated channel subfamily H member 2","drug_class":"Cholinergic Muscarinic Antagonist","quality_score":50,"revenue":null,"mechanism":""},{"drug_id":"darifenacin","indication_name":"Increased Urinary Frequency","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Enablex","generic_name":"DARIFENACIN","company_name":"AbbVie","drug_phase":"marketed","molecular_target":"Muscarinic acetylcholine receptor M3","drug_class":"Cholinergic Muscarinic Antagonist","quality_score":80,"revenue":null,"mechanism":"Enablex works by blocking the action of a chemical called acetylcholine on the bladder muscle, which helps to relax the muscle and improve bladder control."},{"drug_id":"oxybutynin","indication_name":"Increased Urinary Frequency","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Ditropan Xl","generic_name":"OXYBUTYNIN","company_name":"Hisamitsu Pharmaceutical Co., Inc.","drug_phase":"marketed","molecular_target":"Muscarinic acetylcholine receptor M3","drug_class":"Cholinergic Muscarinic Antagonist","quality_score":75,"revenue":null,"mechanism":"Oxybutynin works by blocking the action of a chemical called acetylcholine on the bladder muscle, reducing spasms and urgency."},{"drug_id":"oxytrol","indication_name":"Increased Urinary Frequency","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Oxytrol","company_name":"Jewish General Hospital","drug_phase":"marketed","molecular_target":"Cytochrome P450 2C19, 5-hydroxytryptamine receptor 2B, D(3) dopamine receptor","drug_class":"","quality_score":null,"revenue":null,"mechanism":null}],"pipeline":[],"offLabel":[],"totalMarketed":12,"totalPipeline":0},"trials":{"data":[{"nct_id":"NCT06222515","title":"Bladder Diary for Female Storage LUTS","phase":"","overall_status":"COMPLETED","enrollment_count":4200,"lead_sponsor_name":"National Taiwan University Hospital","has_results":false},{"nct_id":"NCT05064384","title":"Axonics SacRal NeuromodulaTIon System RegisTRY Study","phase":"","overall_status":"COMPLETED","enrollment_count":272,"lead_sponsor_name":"Axonics, Inc.","has_results":true},{"nct_id":"NCT07000656","title":"Micturition Desire-Relaxation Training Device for Lower Urinary Tract Dysfunction in Children","phase":"NA","overall_status":"RECRUITING","enrollment_count":200,"lead_sponsor_name":"Shanghai Children's Medical Center","has_results":false},{"nct_id":"NCT06754189","title":"Safety and Performance of UCon Patch Electrode","phase":"NA","overall_status":"RECRUITING","enrollment_count":180,"lead_sponsor_name":"InnoCon Medical","has_results":false},{"nct_id":"NCT04437108","title":"Efficacy of Li-SWT on Persistent Storage Symptoms After Transurethral Surgery for BPO","phase":"NA","overall_status":"COMPLETED","enrollment_count":132,"lead_sponsor_name":"Mansoura University","has_results":false},{"nct_id":"NCT06694519","title":"Radiofrequency and Exercise-based Rehabilitation on Symptoms Associated With Pelvic Floor Dysfunctions in Breast Cancer","phase":"NA","overall_status":"RECRUITING","enrollment_count":117,"lead_sponsor_name":"SERGIO MONTERO NAVARRO","has_results":false},{"nct_id":"NCT05308979","title":"Intradetrusor Botulinum Toxin A for OAB Via 1 Versus 10 Injections: A Randomized Clinical Trial","phase":"PHASE4","overall_status":"COMPLETED","enrollment_count":116,"lead_sponsor_name":"University of California, Irvine","has_results":true},{"nct_id":"NCT04016324","title":"InterStim Basic Evaluation Lead Post-Market Clinical Follow-up Study","phase":"NA","overall_status":"COMPLETED","enrollment_count":110,"lead_sponsor_name":"MedtronicNeuro","has_results":true},{"nct_id":"NCT04547920","title":"FREEOAB Study for Overactive Bladder","phase":"NA","overall_status":"COMPLETED","enrollment_count":96,"lead_sponsor_name":"Avation Medical, Inc.","has_results":true},{"nct_id":"NCT05368246","title":"Safety and Performance of UCon for the Treatment of the Symptoms of Overactive Bladder (OAB) / Bowel Dysfunction (BD)","phase":"NA","overall_status":"COMPLETED","enrollment_count":80,"lead_sponsor_name":"InnoCon Medical","has_results":false},{"nct_id":"NCT04305743","title":"Post-procedural Pain Associated With 5 Versus 20 Intravesical Injections of Onabotulinumtoxin A","phase":"PHASE4","overall_status":"RECRUITING","enrollment_count":60,"lead_sponsor_name":"University of South Florida","has_results":false},{"nct_id":"NCT04470765","title":"Transcutaneous Tibial Nerve Stimulation: the ZIDA Device Equivalence","phase":"NA","overall_status":"COMPLETED","enrollment_count":40,"lead_sponsor_name":"Exodus Innovations","has_results":false},{"nct_id":"NCT03623880","title":"Enhancing Behavioral Treatment for Women With Pelvic Floor Disorders","phase":"NA","overall_status":"COMPLETED","enrollment_count":38,"lead_sponsor_name":"Northwestern University","has_results":false},{"nct_id":"NCT06695585","title":"Optimal Intravesical Lidocaine Volume for Pain Relief During Office Intra-detrusor Onabotulinum Toxin a Injections","phase":"PHASE4","overall_status":"NOT_YET_RECRUITING","enrollment_count":36,"lead_sponsor_name":"University of Louisville","has_results":false},{"nct_id":"NCT04957524","title":"TEST-ON - Does iStim Reduce Urinary Urgency?","phase":"NA","overall_status":"COMPLETED","enrollment_count":24,"lead_sponsor_name":"University of California, Los Angeles","has_results":false},{"nct_id":"NCT04528784","title":"Feasibility Study of Transcutaneous Tibial Nerve Stimulation for Urinary Symptoms in People With Multiple Sclerosis","phase":"NA","overall_status":"COMPLETED","enrollment_count":23,"lead_sponsor_name":"University of Limerick","has_results":false},{"nct_id":"NCT05874375","title":"UCon Treatment of Overactive Bladder (OAB) in Males","phase":"NA","overall_status":"RECRUITING","enrollment_count":20,"lead_sponsor_name":"InnoCon Medical","has_results":false},{"nct_id":"NCT06091566","title":"Safety and Performance of UCon Bar Electrode for the Treatment of Overactive Bladder (OAB) and Bowel Dysfunction (BD)","phase":"NA","overall_status":"RECRUITING","enrollment_count":20,"lead_sponsor_name":"InnoCon Medical","has_results":false},{"nct_id":"NCT05463822","title":"Transvaginal Botulinum Toxin A Chemodenervation for Overactive Bladder","phase":"EARLY_PHASE1","overall_status":"COMPLETED","enrollment_count":15,"lead_sponsor_name":"Stanford University","has_results":false},{"nct_id":"NCT03131544","title":"MRI Guided Transrectal Prostate Laser Ablation for Benign Prostatic Hypertrophy (BPH)","phase":"NA","overall_status":"COMPLETED","enrollment_count":10,"lead_sponsor_name":"Prostate Laser Center, PLLC","has_results":true},{"nct_id":"NCT03523091","title":"OnabotulinumtoxinA Bladder Injection Study","phase":"PHASE4","overall_status":"TERMINATED","enrollment_count":6,"lead_sponsor_name":"Corewell Health East","has_results":true},{"nct_id":"NCT02060214","title":"Development of Novel Cystometrics for Overactive Bladder","phase":"","overall_status":"WITHDRAWN","enrollment_count":0,"lead_sponsor_name":"Virginia Commonwealth University","has_results":false},{"nct_id":"NCT03043222","title":"Innovative Minimally Invasive Options in Treatment of Urinary Problems Related to Prostate Enlargement (BPH) in Men","phase":"NA","overall_status":"WITHDRAWN","enrollment_count":0,"lead_sponsor_name":"St. Louis University","has_results":false}],"total":23},"guidelines":[],"source":"Drug Landscape verified database"}