{"disease":{"id":"type-1-diabetes-mellitus","name":"type 1 diabetes mellitus"},"drugs":{"marketed":[{"drug_id":"prevnar-family","indication_name":"Streptococcus pneumoniae serotypes 1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F, and 23F in adults 18 years of age and older with chronic heart disease, chronic lung disease, diabetes mellitus, or functional or anatomical asplenia","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Prevnar family","generic_name":"prevnar-family","company_name":"Pfizer Inc.","drug_phase":"marketed","molecular_target":"Streptococcus pneumoniae","drug_class":"Vaccine","quality_score":45,"revenue":"6494","mechanism":"Induces an immune response to Streptococcus pneumoniae serotypes 1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F, and 23F"},{"drug_id":"repaglinide","indication_name":"Not for treatment of type 1 diabetes mellitus","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Prandin","generic_name":"repaglinide","company_name":"Novo Nordisk","drug_phase":"marketed","molecular_target":"ATP-binding cassette sub-family C member 8","drug_class":"Glinide [EPC]","quality_score":80,"revenue":null,"mechanism":"Repaglinide lowers blood glucose levels by stimulating insulin release from the pancreas through ATP-dependent potassium channel blockade."},{"drug_id":"pramlintide","indication_name":"Type 1 Diabetes Mellitus Treatment Adjunct","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Symlin","generic_name":"PRAMLINTIDE","company_name":"Astrazeneca Ab","drug_phase":"marketed","molecular_target":"Amylin receptor AMY2, Amylin receptor AMY1, Amylin receptor AMY3","drug_class":"","quality_score":40,"revenue":null,"mechanism":null}],"pipeline":[],"offLabel":[],"totalMarketed":3,"totalPipeline":0},"trials":{"data":[{"nct_id":"NCT03811470","title":"China Diabetes Registry by Metabolic Management Center","phase":"","overall_status":"RECRUITING","enrollment_count":1000000,"lead_sponsor_name":"Guang Ning","has_results":false},{"nct_id":"NCT06883318","title":"Physical, Psychological and Socioeconomic Effects of Childhood Onset Diabetes in Sweden","phase":"","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":115000,"lead_sponsor_name":"Umeå University","has_results":false},{"nct_id":"NCT03269084","title":"Type 1 Diabetes Prediction and Prevention (DIPP) Study","phase":"","overall_status":"UNKNOWN","enrollment_count":17000,"lead_sponsor_name":"Riitta Veijola","has_results":false},{"nct_id":"NCT00279318","title":"TEDDY - The Environmental Determinants of Diabetes in the Young","phase":"","overall_status":"COMPLETED","enrollment_count":8667,"lead_sponsor_name":"National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)","has_results":false},{"nct_id":"NCT03720197","title":"Registry of Patients Living With Type 1 Diabetes","phase":"","overall_status":"RECRUITING","enrollment_count":6000,"lead_sponsor_name":"Institut de Recherches Cliniques de Montreal","has_results":false},{"nct_id":"NCT03936634","title":"An Innovative Approach Towards Understanding and Arresting Type 1 Diabetes (INNODIA)","phase":"","overall_status":"UNKNOWN","enrollment_count":6000,"lead_sponsor_name":"University of Cambridge","has_results":false},{"nct_id":"NCT06892821","title":"Prospective Cohort Study of Children Diagnosed with Type 1 Diabetes in Türkiye Between 2018 to 2022","phase":"","overall_status":"COMPLETED","enrollment_count":2730,"lead_sponsor_name":"Turkish Pediatric Diabetes Working Group","has_results":false},{"nct_id":"NCT03205865","title":"Diabetes Autoimmunity Study in the Young","phase":"","overall_status":"UNKNOWN","enrollment_count":2700,"lead_sponsor_name":"University of Colorado, Denver","has_results":false},{"nct_id":"NCT06006468","title":"Evaluating ImmuNe Changes in the Evolution of Pre Type 1 Diabetes With Adult ONset","phase":"","overall_status":"COMPLETED","enrollment_count":2250,"lead_sponsor_name":"Royal Devon and Exeter NHS Foundation Trust","has_results":false},{"nct_id":"NCT03610984","title":"Cohort Study of Patients With Type 1 Diabetes","phase":"","overall_status":"COMPLETED","enrollment_count":2110,"lead_sponsor_name":"Second Xiangya Hospital of Central South University","has_results":false},{"nct_id":"NCT07356089","title":"Twiist Postmarket Surveillance Study for Type 1 Diabetes","phase":"","overall_status":"RECRUITING","enrollment_count":1875,"lead_sponsor_name":"Deka Research and Development","has_results":false},{"nct_id":"NCT04821921","title":"The Impact of the COVID-19 Pandemic on Diabetes Management","phase":"","overall_status":"COMPLETED","enrollment_count":1503,"lead_sponsor_name":"Universitätsklinikum Hamburg-Eppendorf","has_results":false},{"nct_id":"NCT03214367","title":"A Study of LY900014 in Participants With Type 1 Diabetes","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":1392,"lead_sponsor_name":"Eli Lilly and Company","has_results":true},{"nct_id":"NCT06606509","title":"The Survey of Treatment and Metabolic Status of Type 1 Diabetes Mellitus (T1DM).","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":1000,"lead_sponsor_name":"Nanjing First Hospital, Nanjing Medical University","has_results":false},{"nct_id":"NCT02268214","title":"Dapagliflozin Evaluation in Patients With Inadequately Controlled Type 1 Diabetes","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":833,"lead_sponsor_name":"AstraZeneca","has_results":true},{"nct_id":"NCT02460978","title":"Dapagliflozin Evaluation in Patients With Inadequately Controlled Type 1 Diabetes","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":815,"lead_sponsor_name":"AstraZeneca","has_results":true},{"nct_id":"NCT03740919","title":"A Study Comparing LY900014 to Insulin Lispro (Humalog) in Children and Adolescents With Type 1 Diabetes","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":751,"lead_sponsor_name":"Eli Lilly and Company","has_results":true},{"nct_id":"NCT07088068","title":"A Study to Investigate Efficacy and Safety of Teplizumab Compared With Placebo in Participants 1 to 25 Years of Age With Stage 3 Type 1 Diabetes","phase":"PHASE3","overall_status":"RECRUITING","enrollment_count":723,"lead_sponsor_name":"Sanofi","has_results":false},{"nct_id":"NCT04429503","title":"Study of a High-Dose Aflibercept in Participants With Diabetic Eye Disease","phase":"PHASE2, PHASE3","overall_status":"COMPLETED","enrollment_count":660,"lead_sponsor_name":"Regeneron Pharmaceuticals","has_results":true},{"nct_id":"NCT02688933","title":"A Study Comparing the Efficacy and Safety of the Morning Injection of Toujeo Versus Lantus in Patients With Type 1 Diabetes Mellitus","phase":"PHASE4","overall_status":"COMPLETED","enrollment_count":638,"lead_sponsor_name":"Sanofi","has_results":true},{"nct_id":"NCT03422965","title":"Perifoveal Vascular Network Assessed by OCT-Angiography in Type I Diabetes Mellitus","phase":"NA","overall_status":"UNKNOWN","enrollment_count":600,"lead_sponsor_name":"Hospital Clinic of Barcelona","has_results":false},{"nct_id":"NCT06676566","title":"Information, Follow-up and Early Diagnosis of Children at Risk for Type 1 Diabetes","phase":"","overall_status":"ENROLLING_BY_INVITATION","enrollment_count":600,"lead_sponsor_name":"Lund University","has_results":false},{"nct_id":"NCT03211858","title":"Comparison of SAR341402 to NovoLog/NovoRapid in Adult Patients With Diabetes Mellitus Also Using Insulin Glargine","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":597,"lead_sponsor_name":"Sanofi","has_results":true},{"nct_id":"NCT02059161","title":"A Study of the Safety and Efficacy of MK-1293 Compared to Lantus™ in Participants With Type 1 Diabetes Mellitus (T1DM) (MK-1293-003)","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":508,"lead_sponsor_name":"Merck Sharp & Dohme LLC","has_results":true},{"nct_id":"NCT06081231","title":"Open-Source Artificial Pancreas System Use Among People With Type 1 Diabetes Mellitus in China","phase":"","overall_status":"RECRUITING","enrollment_count":500,"lead_sponsor_name":"Third Affiliated Hospital, Sun Yat-Sen University","has_results":false},{"nct_id":"NCT07415226","title":"Glucose-lowering Drugs as an Adjunct to Insulin Therapy in Chinese Patients With Type 1 Diabetes","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":500,"lead_sponsor_name":"Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine","has_results":false},{"nct_id":"NCT03830281","title":"A Study Comparing LY900014 to Insulin Lispro (Humalog) in Adults With Type 1 Diabetes Using Insulin Pump Therapy","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":471,"lead_sponsor_name":"Eli Lilly and Company","has_results":true},{"nct_id":"NCT02735044","title":"Comparison of the Safety and Efficacy of HOE901-U300 With Lantus in Children and Adolescents With Type 1 Diabetes Mellitus","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":463,"lead_sponsor_name":"Sanofi","has_results":true},{"nct_id":"NCT06858475","title":"Long-term Observation Of Patient Engagement in Automated Insulin Delivery","phase":"","overall_status":"COMPLETED","enrollment_count":453,"lead_sponsor_name":"Centre Hospitalier Sud Francilien","has_results":false},{"nct_id":"NCT07427134","title":"Pediatric Insulin Plan Calculator for T1DM Management","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":440,"lead_sponsor_name":"Sultan Qaboos University","has_results":false},{"nct_id":"NCT03845465","title":"Positive Psychology Intervention to Treat Diabetes Distress in Teens With Type 1 Diabetes","phase":"NA","overall_status":"COMPLETED","enrollment_count":400,"lead_sponsor_name":"Vanderbilt University Medical Center","has_results":true},{"nct_id":"NCT07149142","title":"Pediatric Artificial Intelligence for Retinopathy Screening in Children With Type 1 Diabetes","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":400,"lead_sponsor_name":"University Hospital, Motol","has_results":false},{"nct_id":"NCT03914547","title":"Home Video-based Telemedicine to Reduce Hypoglycemia Fear in Parents of Young Children","phase":"NA","overall_status":"COMPLETED","enrollment_count":396,"lead_sponsor_name":"Nemours Children's Clinic","has_results":false},{"nct_id":"NCT05252728","title":"Altered Faecal Microbiome and Metabolome in CT1D, AT1D and T2D","phase":"","overall_status":"COMPLETED","enrollment_count":372,"lead_sponsor_name":"Second Xiangya Hospital of Central South University","has_results":false},{"nct_id":"NCT06709755","title":"A Hybrid Effectiveness-implementation Trial to Reduce Diabetes Distress in Teenagers","phase":"NA","overall_status":"RECRUITING","enrollment_count":360,"lead_sponsor_name":"Ann & Robert H Lurie Children's Hospital of Chicago","has_results":false},{"nct_id":"NCT03952130","title":"A Study of LY900014 Compared to Insulin Lispro (Humalog) in Adults With Type 1 Diabetes","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":354,"lead_sponsor_name":"Eli Lilly and Company","has_results":true},{"nct_id":"NCT03202732","title":"DiabetesFlex - Patient Involvement and Patient-reported Outcome Measures in Type 1 Diabetes","phase":"NA","overall_status":"COMPLETED","enrollment_count":344,"lead_sponsor_name":"Annesofie Lunde Jensen","has_results":false},{"nct_id":"NCT04075513","title":"Comparison of Glucose Values and Variability Between TOUJEO and TRESIBA During Continuous Glucose Monitoring in Type 1 Diabetes Patients","phase":"PHASE4","overall_status":"COMPLETED","enrollment_count":343,"lead_sponsor_name":"Sanofi","has_results":true},{"nct_id":"NCT03966911","title":"Performance Evaluation of an Advanced Algorithm With CGM in Adults, Adolescents, and Pediatrics","phase":"NA","overall_status":"COMPLETED","enrollment_count":335,"lead_sponsor_name":"Medtronic MiniMed, Inc.","has_results":true},{"nct_id":"NCT03875729","title":"Recent-Onset Type 1 Diabetes Trial Evaluating Efficacy and Safety of Teplizumab","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":328,"lead_sponsor_name":"Provention Bio, Inc.","has_results":true},{"nct_id":"NCT03069196","title":"Prevalence and Incidence of Complications of Type One Diabetes in PUne At a Tertiary Care CentRE","phase":"","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":323,"lead_sponsor_name":"Kem Hospital, Pune, India","has_results":false},{"nct_id":"NCT04436822","title":"Evaluation of Updated Continuous Glucose Monitoring (CGM) Form Factor in Adults, Adolescents and Pediatrics","phase":"NA","overall_status":"COMPLETED","enrollment_count":317,"lead_sponsor_name":"Medtronic MiniMed, Inc.","has_results":true},{"nct_id":"NCT04454827","title":"Fear of Hypoglycemia in Children and Adolecents With Type 1 Diabetes","phase":"","overall_status":"COMPLETED","enrollment_count":316,"lead_sponsor_name":"University of Ljubljana, Faculty of Medicine","has_results":false},{"nct_id":"NCT03818711","title":"Communication and Coping for Mothers of Adolescents With Type 1 Diabetes","phase":"NA","overall_status":"COMPLETED","enrollment_count":302,"lead_sponsor_name":"Vanderbilt University Medical Center","has_results":true},{"nct_id":"NCT03369821","title":"EXtremely Early-onset Type 1 Diabetes EXtremely Early-onset Type 1 Diabetes (A Musketeers' Memorandum Study)","phase":"","overall_status":"RECRUITING","enrollment_count":300,"lead_sponsor_name":"University of Exeter","has_results":false},{"nct_id":"NCT07086989","title":"Cardiovascular Risk in Children With Chronic Conditions Study","phase":"","overall_status":"RECRUITING","enrollment_count":300,"lead_sponsor_name":"Semmelweis University","has_results":false},{"nct_id":"NCT03328845","title":"Impact on the Oxidative Stress of the Different Analogues of Insulin in People With Type 1 Diabetes. (Ineox Study)","phase":"PHASE4","overall_status":"COMPLETED","enrollment_count":300,"lead_sponsor_name":"Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud","has_results":false},{"nct_id":"NCT03478254","title":"Adherence to Guidelines VAccination in Type 1 DIabetes Mellitus Patients (AVADI-1).","phase":"","overall_status":"COMPLETED","enrollment_count":300,"lead_sponsor_name":"Jesús Moreno Fernández","has_results":true},{"nct_id":"NCT03959423","title":"Safety Evaluation of the Advanced Hybrid Closed Loop (AHCL) System","phase":"NA","overall_status":"COMPLETED","enrollment_count":288,"lead_sponsor_name":"Medtronic MiniMed, Inc.","has_results":true},{"nct_id":"NCT03490773","title":"Type 1 Diabetes, Immunology, Genetics & Endogenous Insulin Production","phase":"","overall_status":"COMPLETED","enrollment_count":287,"lead_sponsor_name":"Royal Devon and Exeter NHS Foundation Trust","has_results":false}],"total":50},"guidelines":[],"source":"Drug Landscape verified database"}