{"disease":{"id":"type-1-diabetes","name":"type 1 diabetes"},"drugs":{"marketed":[{"drug_id":"prevnar-family","indication_name":"Streptococcus pneumoniae serotypes 1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F, and 23F in adults 18 years of age and older with chronic heart disease, chronic lung disease, diabetes mellitus, or functional or anatomical asplenia","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Prevnar family","generic_name":"prevnar-family","company_name":"Pfizer Inc.","drug_phase":"marketed","molecular_target":"Streptococcus pneumoniae","drug_class":"Vaccine","quality_score":45,"revenue":"6494","mechanism":"Induces an immune response to Streptococcus pneumoniae serotypes 1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F, and 23F"},{"drug_id":"15-valent-pneumococcal-conjugate-vaccine-pcv15","indication_name":"Prevention of invasive pneumococcal disease caused by 15 serotypes of Streptococcus pneumoniae in adults 18 years of age and older with diabetes.","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"15-valent pneumococcal conjugate vaccine (PCV15)","generic_name":"15-valent-pneumococcal-conjugate-vaccine-pcv15","company_name":"Pfizer","drug_phase":"marketed","molecular_target":"Streptococcus pneumoniae","drug_class":"vaccine","quality_score":25,"revenue":null,"mechanism":""},{"drug_id":"advanced-therapy-only-without-dietary-intervention","indication_name":"Bone Marrow-Derived Mesenchymal Stem Cells for the Treatment of Type 1 Diabetes","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Advanced therapy only without dietary intervention","generic_name":"advanced-therapy-only-without-dietary-intervention","company_name":"Pfizer","drug_phase":"marketed","molecular_target":"various cell types","drug_class":"advanced therapy","quality_score":40,"revenue":null,"mechanism":""},{"drug_id":"teplizumab-mzwv","indication_name":"Delay onset of Stage 3 type 1 diabetes","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"TZIELD","generic_name":"TEPLIZUMAB-MZWV","company_name":"PROVENTION BIO INC","drug_phase":"marketed","molecular_target":"T-cell surface glycoprotein CD3","drug_class":"CD3-directed Antibody [EPC]","quality_score":17,"revenue":null,"mechanism":""},{"drug_id":"pramlintide","indication_name":"Type 1 Diabetes Mellitus Treatment Adjunct","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Symlin","generic_name":"PRAMLINTIDE","company_name":"Astrazeneca Ab","drug_phase":"marketed","molecular_target":"Amylin receptor AMY2, Amylin receptor AMY1, Amylin receptor AMY3","drug_class":"","quality_score":40,"revenue":null,"mechanism":null},{"drug_id":"repaglinide","indication_name":"Not for treatment of type 1 diabetes mellitus","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Prandin","generic_name":"repaglinide","company_name":"Novo Nordisk","drug_phase":"marketed","molecular_target":"ATP-binding cassette sub-family C member 8","drug_class":"Glinide [EPC]","quality_score":80,"revenue":null,"mechanism":"Repaglinide lowers blood glucose levels by stimulating insulin release from the pancreas through ATP-dependent potassium channel blockade."}],"pipeline":[{"drug_id":"chlorthalidone","indication_name":"Safety and efficacy of chlorthalidone in type 1 diabetes","indication_type":"pipeline","phase":"Phase 2","line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"CHLORTHALIDONE","company_name":"","drug_phase":"marketed","molecular_target":"Na+/Cl− cotransporter","drug_class":"Thiazide-like Diuretic [EPC]","quality_score":65,"revenue":null,"mechanism":""}],"offLabel":[],"totalMarketed":6,"totalPipeline":1},"trials":{"data":[{"nct_id":"NCT03811470","title":"China Diabetes Registry by Metabolic Management Center","phase":"","overall_status":"RECRUITING","enrollment_count":1000000,"lead_sponsor_name":"Guang Ning","has_results":false},{"nct_id":"NCT06563401","title":"Mortality and Cardiovascular Diseases in Adult-onset Type 1 Diabetes","phase":"","overall_status":"RECRUITING","enrollment_count":900000,"lead_sponsor_name":"Karolinska Institutet","has_results":false},{"nct_id":"NCT06883318","title":"Physical, Psychological and Socioeconomic Effects of Childhood Onset Diabetes in Sweden","phase":"","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":115000,"lead_sponsor_name":"Umeå University","has_results":false},{"nct_id":"NCT05713448","title":"Prevalence of Overweight and Obesity in Adult Patients Suffering From Type 1 Diabetes","phase":"","overall_status":"RECRUITING","enrollment_count":100000,"lead_sponsor_name":"Universitaire Ziekenhuizen KU Leuven","has_results":false},{"nct_id":"NCT04239521","title":"The Epidemiology, Management, and the Associated Burden of Related Conditions in Alopecia Areata","phase":"","overall_status":"COMPLETED","enrollment_count":51955,"lead_sponsor_name":"Momentum Data","has_results":false},{"nct_id":"NCT04629586","title":"The T1D Exchange Registry","phase":"","overall_status":"RECRUITING","enrollment_count":50000,"lead_sponsor_name":"T1D Exchange, United States","has_results":false},{"nct_id":"NCT04834518","title":"Screening for Islet Autoantibodies in the Israeli Paediatric General Population for Detection of Pre-symptomatic Type-1 Diabetes Mellitus","phase":"","overall_status":"RECRUITING","enrollment_count":50000,"lead_sponsor_name":"Rabin Medical Center","has_results":false},{"nct_id":"NCT06552923","title":"Extension for Community Health Outcomes (ECHO) Diabetes Program","phase":"NA","overall_status":"COMPLETED","enrollment_count":32796,"lead_sponsor_name":"University of Florida","has_results":false},{"nct_id":"NCT06665815","title":"A National Screening Program for Islet Autoantibodies Among First-degree Relatives of T1D Patients","phase":"","overall_status":"RECRUITING","enrollment_count":20000,"lead_sponsor_name":"Rabin Medical Center","has_results":false},{"nct_id":"NCT05498974","title":"China Diabetes Type 1 Study (CD1S) by China Alliance for Type 1 Diabetes","phase":"","overall_status":"RECRUITING","enrollment_count":20000,"lead_sponsor_name":"Second Xiangya Hospital of Central South University","has_results":false},{"nct_id":"NCT03269084","title":"Type 1 Diabetes Prediction and Prevention (DIPP) Study","phase":"","overall_status":"UNKNOWN","enrollment_count":17000,"lead_sponsor_name":"Riitta Veijola","has_results":false},{"nct_id":"NCT04958356","title":"Newborn Screening for Genetic Susceptibility to Type 1 Diabetes and Celiac Disease and Prospective Follow-up Study","phase":"","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":9690,"lead_sponsor_name":"University of Helsinki","has_results":false},{"nct_id":"NCT00279318","title":"TEDDY - The Environmental Determinants of Diabetes in the Young","phase":"","overall_status":"COMPLETED","enrollment_count":8667,"lead_sponsor_name":"National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)","has_results":false},{"nct_id":"NCT02620917","title":"Continuos Subcutaneous Insulin Infusion in Italy","phase":"","overall_status":"COMPLETED","enrollment_count":6623,"lead_sponsor_name":"University of Padova","has_results":true},{"nct_id":"NCT03720197","title":"Registry of Patients Living With Type 1 Diabetes","phase":"","overall_status":"RECRUITING","enrollment_count":6000,"lead_sponsor_name":"Institut de Recherches Cliniques de Montreal","has_results":false},{"nct_id":"NCT03936634","title":"An Innovative Approach Towards Understanding and Arresting Type 1 Diabetes (INNODIA)","phase":"","overall_status":"UNKNOWN","enrollment_count":6000,"lead_sponsor_name":"University of Cambridge","has_results":false},{"nct_id":"NCT06141434","title":"PRenatal and Obstetric Maternal Exposures and ISlet Autoantibodies in Early Life","phase":"","overall_status":"RECRUITING","enrollment_count":6000,"lead_sponsor_name":"University of Colorado, Denver","has_results":false},{"nct_id":"NCT06314048","title":"4T Sustainability Program","phase":"","overall_status":"ENROLLING_BY_INVITATION","enrollment_count":5000,"lead_sponsor_name":"Stanford University","has_results":false},{"nct_id":"NCT04162067","title":"The Current Health Status of Patients Living With Type 1 Diabetes From the LMC Diabetes Patient Registry","phase":"","overall_status":"COMPLETED","enrollment_count":3600,"lead_sponsor_name":"LMC Diabetes & Endocrinology Ltd.","has_results":false},{"nct_id":"NCT07038473","title":"Early Detection of Type 1 Diabetes in First Degree Relatives of Type 1 Diabetes Patients (DETECT T1D GULF)","phase":"NA","overall_status":"RECRUITING","enrollment_count":3500,"lead_sponsor_name":"Sanofi","has_results":false},{"nct_id":"NCT07097805","title":"Glycemic Improvement With Team, Technology, Education and Peer Resources in Type 1 Diabetes-GLITTER Study","phase":"NA","overall_status":"RECRUITING","enrollment_count":3000,"lead_sponsor_name":"Second Xiangya Hospital of Central South University","has_results":false},{"nct_id":"NCT04761094","title":"Clinical Efficacy of Insulin Pumps in Type 1 Diabetes Mellitus Patients in Spain","phase":"","overall_status":"COMPLETED","enrollment_count":2977,"lead_sponsor_name":"Castilla-La Mancha Health Service","has_results":false},{"nct_id":"NCT05899439","title":"Immune Function and the Progression to T1D","phase":"","overall_status":"RECRUITING","enrollment_count":2800,"lead_sponsor_name":"University of Florida","has_results":false},{"nct_id":"NCT06892821","title":"Prospective Cohort Study of Children Diagnosed with Type 1 Diabetes in Türkiye Between 2018 to 2022","phase":"","overall_status":"COMPLETED","enrollment_count":2730,"lead_sponsor_name":"Turkish Pediatric Diabetes Working Group","has_results":false},{"nct_id":"NCT05646017","title":"Effect of Heatwave Over Glycemic Control in Patients With T1D","phase":"","overall_status":"COMPLETED","enrollment_count":2701,"lead_sponsor_name":"Castilla-La Mancha Health Service","has_results":false},{"nct_id":"NCT03205865","title":"Diabetes Autoimmunity Study in the Young","phase":"","overall_status":"UNKNOWN","enrollment_count":2700,"lead_sponsor_name":"University of Colorado, Denver","has_results":false},{"nct_id":"NCT05678543","title":"Danish Diabetes Birth Registry 2","phase":"","overall_status":"RECRUITING","enrollment_count":2500,"lead_sponsor_name":"Odense University Hospital","has_results":false},{"nct_id":"NCT06006468","title":"Evaluating ImmuNe Changes in the Evolution of Pre Type 1 Diabetes With Adult ONset","phase":"","overall_status":"COMPLETED","enrollment_count":2250,"lead_sponsor_name":"Royal Devon and Exeter NHS Foundation Trust","has_results":false},{"nct_id":"NCT03610984","title":"Cohort Study of Patients With Type 1 Diabetes","phase":"","overall_status":"COMPLETED","enrollment_count":2110,"lead_sponsor_name":"Second Xiangya Hospital of Central South University","has_results":false},{"nct_id":"NCT05324488","title":"Diabetes Registry Graz for Biomarker Research","phase":"","overall_status":"RECRUITING","enrollment_count":2000,"lead_sponsor_name":"Medical University of Graz","has_results":false},{"nct_id":"NCT06082063","title":"Multifactorial Intervention to Reduce Cardiovascular Disease in Type 1 Diabetes","phase":"PHASE3","overall_status":"RECRUITING","enrollment_count":2000,"lead_sponsor_name":"Steno Diabetes Center Copenhagen","has_results":false},{"nct_id":"NCT07356089","title":"Twiist Postmarket Surveillance Study for Type 1 Diabetes","phase":"","overall_status":"RECRUITING","enrollment_count":1875,"lead_sponsor_name":"Deka Research and Development","has_results":false},{"nct_id":"NCT04821921","title":"The Impact of the COVID-19 Pandemic on Diabetes Management","phase":"","overall_status":"COMPLETED","enrollment_count":1503,"lead_sponsor_name":"Universitätsklinikum Hamburg-Eppendorf","has_results":false},{"nct_id":"NCT03214367","title":"A Study of LY900014 in Participants With Type 1 Diabetes","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":1392,"lead_sponsor_name":"Eli Lilly and Company","has_results":true},{"nct_id":"NCT07479329","title":"Estimated Risk of Preeclampsia in the First Trimester and Its Association With Subclinical Atherosclerosis and Cardiovascular Risk in Women With Type 1 Diabetes","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":1300,"lead_sponsor_name":"Institut d'Investigacions Biomèdiques August Pi i Sunyer","has_results":false},{"nct_id":"NCT00340938","title":"Family Management of Childhood Diabetes Study","phase":"PHASE1","overall_status":"COMPLETED","enrollment_count":1298,"lead_sponsor_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)","has_results":false},{"nct_id":"NCT06670625","title":"Intensive Dietary and Activity Counselling (IDAC)","phase":"NA","overall_status":"RECRUITING","enrollment_count":1244,"lead_sponsor_name":"Lund University","has_results":false},{"nct_id":"NCT05013346","title":"Characteristics of Young-onset Diabetes in Sub-Saharan Africa (YODA) Study","phase":"","overall_status":"UNKNOWN","enrollment_count":1200,"lead_sponsor_name":"Yaounde Central Hospital","has_results":false},{"nct_id":"NCT04814849","title":"Parents' Occupation After Diabetes Onset","phase":"","overall_status":"COMPLETED","enrollment_count":1144,"lead_sponsor_name":"Hannover Medical School","has_results":false},{"nct_id":"NCT04593888","title":"Gluten Reduction and Risk of Celiac Disease","phase":"NA","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":1141,"lead_sponsor_name":"Lund University","has_results":false},{"nct_id":"NCT05095610","title":"Clinical Effects of Intermitent Continuous Glucose Monitoring in Type 1 Diabetes","phase":"","overall_status":"COMPLETED","enrollment_count":1121,"lead_sponsor_name":"Castilla-La Mancha Health Service","has_results":false},{"nct_id":"NCT07360080","title":"Long-Term Outcomes of Teplizumab in Routine Clinical Care","phase":"","overall_status":"RECRUITING","enrollment_count":1000,"lead_sponsor_name":"Sanofi","has_results":false},{"nct_id":"NCT04334707","title":"Kidney Precision Medicine Project","phase":"","overall_status":"RECRUITING","enrollment_count":1000,"lead_sponsor_name":"Icahn School of Medicine at Mount Sinai","has_results":false},{"nct_id":"NCT06654713","title":"Commercial or Open Source Closed Loop Impact on Pregnancy Study","phase":"","overall_status":"RECRUITING","enrollment_count":1000,"lead_sponsor_name":"University of California, San Francisco","has_results":false},{"nct_id":"NCT06770621","title":"Longitudinal Study of the GLUcagon REsponse to Hypoglycemia in Children and Adolescents With New-onset Type 1 DIAbetes","phase":"NA","overall_status":"RECRUITING","enrollment_count":1000,"lead_sponsor_name":"Cliniques universitaires Saint-Luc- Université Catholique de Louvain","has_results":false},{"nct_id":"NCT06606509","title":"The Survey of Treatment and Metabolic Status of Type 1 Diabetes Mellitus (T1DM).","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":1000,"lead_sponsor_name":"Nanjing First Hospital, Nanjing Medical University","has_results":false},{"nct_id":"NCT07322380","title":"Feasibility and Adoption of a Screening Program for T1D Relatives in Canada","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":1000,"lead_sponsor_name":"Institut de Recherches Cliniques de Montreal","has_results":false},{"nct_id":"NCT02748018","title":"Multi-center Trial in Adult and Pediatric Patients With Type 1 Diabetes Using Hybrid Closed Loop System and Control at Home","phase":"NA","overall_status":"COMPLETED","enrollment_count":959,"lead_sponsor_name":"Medtronic MiniMed, Inc.","has_results":true},{"nct_id":"NCT05109520","title":"Evaluation of Glycemic Control and Quality of Life in Adults With Type 1 Diabetes During Continuous Glucose Monitoring When Switching to Insulin Glargine 300 U/mL","phase":"","overall_status":"COMPLETED","enrollment_count":867,"lead_sponsor_name":"prof dr Pieter Gillard","has_results":false},{"nct_id":"NCT02268214","title":"Dapagliflozin Evaluation in Patients With Inadequately Controlled Type 1 Diabetes","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":833,"lead_sponsor_name":"AstraZeneca","has_results":true}],"total":50},"guidelines":[],"source":"Drug Landscape verified database"}