{"disease":{"id":"trigeminal-neuralgia","name":"Trigeminal neuralgia","therapeutic_area":"","data":{},"enrichment_level":0,"last_enriched_at":null,"visit_count":0,"created_at":"2026-04-19T18:31:21.150Z","updated_at":"2026-04-19T18:39:44.960Z","meddra_pt":null,"meddra_code":null,"icd10_codes":null,"synonyms":[],"prevalence_global":null,"prevalence_us":null,"marketed_drug_count":2,"pipeline_drug_count":0,"trial_count":1},"drugs":{"marketed":[{"drug_id":"carbamazepine","indication_name":"Trigeminal Neuralgia","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Tegretol","generic_name":"carbamazepine","company_name":"Novartis AG (originally Geigy)","drug_phase":"marketed","molecular_target":"Frizzled-8, Nuclear receptor subfamily 1 group I member 2, Neuronal acetylcholine receptor; alpha2/beta4","drug_class":"Mood Stabilizer [EPC]","quality_score":62,"revenue":null,"mechanism":"Carbamazepine reduces polysynaptic responses and blocks post-tetanic potentiation, potentially alleviating seizures and pain."},{"drug_id":"carbamazepine","indication_name":"Trigeminal neuralgia","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Tegretol","generic_name":"carbamazepine","company_name":"Novartis AG (originally Geigy)","drug_phase":"marketed","molecular_target":"Frizzled-8, Nuclear receptor subfamily 1 group I member 2, Neuronal acetylcholine receptor; alpha2/beta4","drug_class":"Mood Stabilizer [EPC]","quality_score":62,"revenue":null,"mechanism":"Carbamazepine reduces polysynaptic responses and blocks post-tetanic potentiation, potentially alleviating seizures and pain."},{"drug_id":"carbamazepin","indication_name":"Trigeminal neuralgia","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Carbamazepin","company_name":"Enanta Pharmaceuticals, Inc","drug_phase":"marketed","molecular_target":"Frizzled-8, Nuclear receptor subfamily 1 group I member 2, Neuronal acetylcholine receptor; alpha2/beta4","drug_class":"","quality_score":19,"revenue":null,"mechanism":null}],"pipeline":[],"offLabel":[],"totalMarketed":3,"totalPipeline":0},"trials":{"data":[{"nct_id":"NCT07135024","title":"Prospective Register Study to Assess Eligibility for and Efficacy of Surgical Treatment in Patients With nEuRovascular Conflict","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":5001,"lead_sponsor_name":"Gerrit A Schubert","has_results":false},{"nct_id":"NCT07238244","title":"Risk Factors for Recurrence of Trigeminal Neuralgia After Percutaneous Balloon Compression","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":700,"lead_sponsor_name":"Second Xiangya Hospital of Central South University","has_results":false},{"nct_id":"NCT06518421","title":"Emotion and Memory in Chronic Neuropathic Pain","phase":"","overall_status":"RECRUITING","enrollment_count":400,"lead_sponsor_name":"University Health Network, Toronto","has_results":false},{"nct_id":"NCT06472323","title":"The Efficacy and Safety of Pulsed Radiofrequency Combined With Platelet-rich Plasma for the Trigeminal Neuralgia","phase":"","overall_status":"RECRUITING","enrollment_count":270,"lead_sponsor_name":"Beijing Tiantan Hospital","has_results":false},{"nct_id":"NCT03593330","title":"Neurosurgical Transitional Care Programme","phase":"NA","overall_status":"TERMINATED","enrollment_count":242,"lead_sponsor_name":"Barts & The London NHS Trust","has_results":false},{"nct_id":"NCT06410859","title":"Botulinum Toxin Type A for Injection (HengLi®) in the Treatment of Trigeminal Neuralgia","phase":"PHASE2","overall_status":"ENROLLING_BY_INVITATION","enrollment_count":240,"lead_sponsor_name":"LKGS_277","has_results":false},{"nct_id":"NCT04570293","title":"5% Lidocaine-medicated Plaster for the Treatment of Trigeminal Neuralgia","phase":"PHASE4","overall_status":"COMPLETED","enrollment_count":226,"lead_sponsor_name":"Beijing Tiantan Hospital","has_results":false},{"nct_id":"NCT04467398","title":"Incidence of Intravascular (IV) Injection During Trigeminal Nerve Blocks","phase":"","overall_status":"UNKNOWN","enrollment_count":200,"lead_sponsor_name":"Seoul National University","has_results":false},{"nct_id":"NCT06890897","title":"Esketamine Combined Pulsed Radiofrequency for Acute/Subacute Zoster-associated Trigeminal Neuralgia","phase":"NA","overall_status":"RECRUITING","enrollment_count":174,"lead_sponsor_name":"Beijing Tiantan Hospital","has_results":false},{"nct_id":"NCT05217628","title":"An Efficacy and Safety Study of Basimglurant (NOE-101) in Patients With Trigeminal Neuralgia.","phase":"PHASE2, PHASE3","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":166,"lead_sponsor_name":"Noema Pharma AG","has_results":false},{"nct_id":"NCT03331913","title":"Botulinum Toxin for Trigeminal Neuralgia","phase":"PHASE3","overall_status":"UNKNOWN","enrollment_count":150,"lead_sponsor_name":"The First Affiliated Hospital of Zhengzhou University","has_results":false},{"nct_id":"NCT07046247","title":"Impact of Teflon Technique on Recurrence After Microvascular Decompression for Trigeminal Neuralgia","phase":"","overall_status":"COMPLETED","enrollment_count":150,"lead_sponsor_name":"University of Valencia","has_results":false},{"nct_id":"NCT04174443","title":"The Efficacy and Safety of Pulsed Radiofrequency Combined With Continuous Radiofrequency for the Trigeminal Neuralgia","phase":"NA","overall_status":"COMPLETED","enrollment_count":146,"lead_sponsor_name":"Beijing Tiantan Hospital","has_results":false},{"nct_id":"NCT03131466","title":"High-voltage Pulsed Radiofrequency on Gasserian Ganglion to Treat Patients With Primary Trigeminal Neuralgia","phase":"NA","overall_status":"COMPLETED","enrollment_count":134,"lead_sponsor_name":"Beijing Tiantan Hospital","has_results":false},{"nct_id":"NCT04996199","title":"Comparision Efficacy of Carbamazepine & Oxcarbazepine in the Treatment of Trigeminal Neuralgia- a Randomised Clinical Trial","phase":"PHASE4","overall_status":"UNKNOWN","enrollment_count":132,"lead_sponsor_name":"Postgraduate Institute of Dental Sciences Rohtak","has_results":false},{"nct_id":"NCT06977932","title":"The Alternative Effects of Electroacupuncture in the Treatment of Trigeminal Neuralgia","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":126,"lead_sponsor_name":"Yuanyuan Wu","has_results":false},{"nct_id":"NCT06849219","title":"Comparison of Oxcarbazepine Versus Carbamazepine in the Management of Trigeminal Neuralgia","phase":"PHASE4","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":122,"lead_sponsor_name":"Jinnah Postgraduate Medical Centre","has_results":false},{"nct_id":"NCT07252453","title":"Comparison b/w Carbamazepine vs Oxcarbazepine in Treatment of Trigeminal Neuralgia","phase":"NA","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":122,"lead_sponsor_name":"Abbasi Shaheed Hospital","has_results":false},{"nct_id":"NCT06853119","title":"Magnetic Resonance Imaging in Patients with Trigeminal Neuralgia","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":120,"lead_sponsor_name":"Tongji Hospital","has_results":false},{"nct_id":"NCT03580317","title":"Electroacupuncture Therapy for Change of Pain in Classical Trigeminal Neuralgia","phase":"NA","overall_status":"COMPLETED","enrollment_count":120,"lead_sponsor_name":"Zhejiang Chinese Medical University","has_results":false},{"nct_id":"NCT05075707","title":"Comparison Between Magnetic Field and Laser Therapy in Management of Trigeminal Neuralgia","phase":"NA","overall_status":"COMPLETED","enrollment_count":120,"lead_sponsor_name":"Delta University for Science and Technology","has_results":false},{"nct_id":"NCT04445766","title":"Efficacy and Complications of Microvascular Decompression","phase":"","overall_status":"COMPLETED","enrollment_count":115,"lead_sponsor_name":"Danish Headache Center","has_results":false},{"nct_id":"NCT06998420","title":"Developing a Clinical Prediction Model for Adverse Outcomes in Percutaneous Trigeminal Ganglion Balloon Compression","phase":"","overall_status":"COMPLETED","enrollment_count":110,"lead_sponsor_name":"Affiliated Hospital of Nantong University","has_results":false},{"nct_id":"NCT06261801","title":"Efficacy of Electroacupuncture Combined With Pregabalin in the Treatment of Trigeminal Herpetic Neuralgia: a Multicenter Randomized Controlled Trial Study Protocol","phase":"NA","overall_status":"RECRUITING","enrollment_count":102,"lead_sponsor_name":"The Third People's Hospital of Hangzhou","has_results":false},{"nct_id":"NCT07216547","title":"Post-Operative Trigeminal Pain After Microvascular Decompression for Trigeminal Neuralgia","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":100,"lead_sponsor_name":"Rutgers, The State University of New Jersey","has_results":false},{"nct_id":"NCT03152955","title":"Postoperative Analgesia in Patients With Microvascular Decompression","phase":"PHASE4","overall_status":"UNKNOWN","enrollment_count":90,"lead_sponsor_name":"Xiangya Hospital of Central South University","has_results":false},{"nct_id":"NCT06174818","title":"Pulsed Radiofrequency Treatment Of the Gasserian Ganglion for tRigeminal nEuralgia: a retroSpective Study","phase":"","overall_status":"COMPLETED","enrollment_count":85,"lead_sponsor_name":"Ziekenhuis Oost-Limburg","has_results":false},{"nct_id":"NCT03991039","title":"Comparing Clinical Benefits of Gamma Knife and Microvascular Decompression for Trigeminal Neuralgia","phase":"NA","overall_status":"COMPLETED","enrollment_count":84,"lead_sponsor_name":"University of Baghdad","has_results":false},{"nct_id":"NCT03066037","title":"Regional-anaesthesiological Infiltration Techniques for the Management of Chronic Pain: a Retrospective Study","phase":"","overall_status":"COMPLETED","enrollment_count":83,"lead_sponsor_name":"Charite University, Berlin, Germany","has_results":false},{"nct_id":"NCT06315790","title":"Safety and Efficacy of Botulinum Toxin A in Patients With Trigeminal Neuralgia","phase":"PHASE3","overall_status":"UNKNOWN","enrollment_count":80,"lead_sponsor_name":"Henrik Schytz","has_results":false},{"nct_id":"NCT06949436","title":"Ultra-Early Gamma Knife Stereotactic Radiosurgery for TN","phase":"PHASE2","overall_status":"RECRUITING","enrollment_count":80,"lead_sponsor_name":"University of Alberta","has_results":false},{"nct_id":"NCT01540630","title":"A Phase IIa Withdrawal Study of CNV1014802 in Patients With Trigeminal Neuralgia","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":67,"lead_sponsor_name":"Biogen","has_results":false},{"nct_id":"NCT03941834","title":"Trial for Treatment Refractory Trigeminal Neuralgia","phase":"PHASE2","overall_status":"TERMINATED","enrollment_count":65,"lead_sponsor_name":"Pfizer","has_results":true},{"nct_id":"NCT03778177","title":"Neurophysiologic Signatures of Trigeminal Neuralgia Pain","phase":"NA","overall_status":"COMPLETED","enrollment_count":61,"lead_sponsor_name":"University of Florida","has_results":false},{"nct_id":"NCT06684275","title":"Comparison of Pulsed and Thermal Radiofrequency for Trigeminal Neuralgia","phase":"NA","overall_status":"RECRUITING","enrollment_count":60,"lead_sponsor_name":"Zagazig University","has_results":false},{"nct_id":"NCT06290661","title":"Clinical Trial of the Safety and Efficacy of Peripheral Nerve Stimulation in the Treatment of Peripheral Neuropathic Pain.","phase":"NA","overall_status":"RECRUITING","enrollment_count":60,"lead_sponsor_name":"Union Hospital, Tongji Medical College, Huazhong University of Science and Technology","has_results":false},{"nct_id":"NCT04371575","title":"Symptomatic Trigeminal Neuralgia Attributed to Multiple Sclerosis - a Prospective Study in 60 Patients","phase":"","overall_status":"COMPLETED","enrollment_count":60,"lead_sponsor_name":"Stine Maarbjerg, MD PhD","has_results":false},{"nct_id":"NCT07013500","title":"Comparison of Two Types of Radiofrequency Treatment for Trigeminal Neuralgia","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":60,"lead_sponsor_name":"Mesut Bakır","has_results":false},{"nct_id":"NCT05328661","title":"Pathophysiological Mechanisms of Trigeminal Neuralgia - Neurophysiological Assessment of the Blink-reflex","phase":"","overall_status":"COMPLETED","enrollment_count":60,"lead_sponsor_name":"Danish Headache Center","has_results":false},{"nct_id":"NCT06620172","title":"CT-guided vs Fluoroscopy-guided Trigeminal Ganglion Radiofrequency Thermocoagulation for Idiopathic Trigeminal Neuralgia","phase":"NA","overall_status":"RECRUITING","enrollment_count":60,"lead_sponsor_name":"Zagazig University","has_results":false},{"nct_id":"NCT05516888","title":"Comparison of the Radiofrequency Treatments for the Treatment of Trigeminal Neuralgia.","phase":"NA","overall_status":"COMPLETED","enrollment_count":60,"lead_sponsor_name":"Diskapi Teaching and Research Hospital","has_results":false},{"nct_id":"NCT06240494","title":"Predictive Factors in Maxillary and Mandibular Nerve Radiofrequency Treatment for Trigeminal Neuralgia","phase":"","overall_status":"COMPLETED","enrollment_count":58,"lead_sponsor_name":"Diskapi Teaching and Research Hospital","has_results":false},{"nct_id":"NCT05101577","title":"Recurrence of Trigeminal Neuralgia in Patient's Undergoing Radiofrequency Ablation","phase":"","overall_status":"COMPLETED","enrollment_count":56,"lead_sponsor_name":"Shifa Clinical Research Center","has_results":false},{"nct_id":"NCT02713646","title":"Magnetic Resonance Imaging Study on Patients With Trigeminal Neuralgia","phase":"","overall_status":"COMPLETED","enrollment_count":55,"lead_sponsor_name":"First Affiliated Hospital Xi'an Jiaotong University","has_results":false},{"nct_id":"NCT07370142","title":"Sphenopalatine Ganglion Pulsed Radiofrequency Treatment Outcomes","phase":"NA","overall_status":"COMPLETED","enrollment_count":55,"lead_sponsor_name":"Ankara City Hospital Bilkent","has_results":false},{"nct_id":"NCT05032573","title":"Feasibility of Olive Oil for Reducing Facial Pain of Trigeminal Neuralgia","phase":"NA","overall_status":"COMPLETED","enrollment_count":52,"lead_sponsor_name":"University of Florida","has_results":false},{"nct_id":"NCT05810428","title":"Artificial Intelligence to Predict Surgical Outcomes and Assess Pain Neuromodulation in Trigeminal Neuralgia Subjects","phase":"NA","overall_status":"ENROLLING_BY_INVITATION","enrollment_count":50,"lead_sponsor_name":"IRCCS San Raffaele","has_results":false},{"nct_id":"NCT06440356","title":"Effect of Non-invasive Photobiomodulation Therapies in Patients With Trigeminal Neuralgia","phase":"NA","overall_status":"COMPLETED","enrollment_count":45,"lead_sponsor_name":"University of Gaziantep","has_results":false},{"nct_id":"NCT06366139","title":"Trigeminal Ganglion RFT vs Maxillary/Mandibular PRF in the Treatment of Trigeminal Neuralgia","phase":"NA","overall_status":"COMPLETED","enrollment_count":44,"lead_sponsor_name":"Diskapi Teaching and Research Hospital","has_results":false},{"nct_id":"NCT05712993","title":"Comparative Study Between Transcoronoid and Infrazygomatic Anterior Maneuvers","phase":"NA","overall_status":"COMPLETED","enrollment_count":40,"lead_sponsor_name":"Iraqi Board of medical specialties","has_results":false}],"total":50},"guidelines":[],"source":"Drug Landscape verified database"}