{"disease":{"id":"treatment-resistant-depressive-disorder","name":"treatment resistant depressive disorder"},"drugs":{"marketed":[],"pipeline":[],"offLabel":[],"totalMarketed":0,"totalPipeline":0},"trials":{"data":[{"nct_id":"NCT02960763","title":"Optimizing Outcomes of Treatment-Resistant Depression in Older Adults","phase":"PHASE4","overall_status":"COMPLETED","enrollment_count":742,"lead_sponsor_name":"Washington University School of Medicine","has_results":true},{"nct_id":"NCT06462196","title":"Natural History of Depression, Bipolar Disorder and Suicide Risk","phase":"","overall_status":"RECRUITING","enrollment_count":500,"lead_sponsor_name":"National Institute of Mental Health (NIMH)","has_results":false},{"nct_id":"NCT03113968","title":"ELEKT-D: Electroconvulsive Therapy (ECT) vs. Ketamine in Patients With Treatment Resistant Depression (TRD)","phase":"PHASE2, PHASE3","overall_status":"COMPLETED","enrollment_count":403,"lead_sponsor_name":"Bo Hu","has_results":true},{"nct_id":"NCT02977299","title":"Comparative Effectiveness Research Trial for Antidepressant Incomplete and Non-responders With TRD","phase":"PHASE4","overall_status":"COMPLETED","enrollment_count":278,"lead_sponsor_name":"Massachusetts General Hospital","has_results":false},{"nct_id":"NCT06350396","title":"pBFS-guided rTMS Over DMPFC for Treatment-Resistant Depression","phase":"NA","overall_status":"RECRUITING","enrollment_count":270,"lead_sponsor_name":"Changping Laboratory","has_results":false},{"nct_id":"NCT04634669","title":"Open-Label Safety Study of AXS-05 in Subjects With TRD (EVOLVE)","phase":"PHASE2","overall_status":"TERMINATED","enrollment_count":181,"lead_sponsor_name":"Axsome Therapeutics, Inc.","has_results":true},{"nct_id":"NCT05641623","title":"OSU6162 as add-on in SSRI/SNRI-resistant Depression","phase":"PHASE2","overall_status":"RECRUITING","enrollment_count":180,"lead_sponsor_name":"Göteborg University","has_results":false},{"nct_id":"NCT05948839","title":"pBFS Guided rTMS Over DMPFC for Treatment-Resistant Depression","phase":"NA","overall_status":"UNKNOWN","enrollment_count":170,"lead_sponsor_name":"Changping Laboratory","has_results":false},{"nct_id":"NCT03435744","title":"Simvastatin as an Augmentation Treatment for Treatment Resistant Depression: Randomized Controlled Trial.","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":150,"lead_sponsor_name":"Pakistan Institute of Living and Learning","has_results":false},{"nct_id":"NCT06396312","title":"Deep Phenotyping for Clinical Inferring Response in Treatment Resistant Depression","phase":"","overall_status":"RECRUITING","enrollment_count":130,"lead_sponsor_name":"Max-Planck-Institute of Psychiatry","has_results":false},{"nct_id":"NCT07512284","title":"Mindfulness Engaged Neurostimulation for Depression (MEND II)","phase":"PHASE2","overall_status":"NOT_YET_RECRUITING","enrollment_count":120,"lead_sponsor_name":"University of California, San Diego","has_results":false},{"nct_id":"NCT01998958","title":"A Study to Evaluate the Safety and Efficacy of Intranasal Esketamine in Treatment-resistant Depression","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":108,"lead_sponsor_name":"Janssen Research & Development, LLC","has_results":true},{"nct_id":"NCT06132178","title":"Psilocybin rTMS for Treatment Resistant Depression","phase":"PHASE2","overall_status":"RECRUITING","enrollment_count":100,"lead_sponsor_name":"University of Texas at Austin","has_results":false},{"nct_id":"NCT06091163","title":"Ketogenic Diet for Treatment-Resistant Depression: Dietary Interventions for MEntal Health Study (DIME)","phase":"NA","overall_status":"COMPLETED","enrollment_count":88,"lead_sponsor_name":"University of Oxford","has_results":false},{"nct_id":"NCT05531591","title":"RCT of Brain Longitudinal Biomarker Study (OPT-Neuro RCT)","phase":"PHASE4","overall_status":"COMPLETED","enrollment_count":87,"lead_sponsor_name":"Centre for Addiction and Mental Health","has_results":false},{"nct_id":"NCT04226963","title":"A Naturalistic Study of Ketamine for Treatment Resistant Mood Disorders","phase":"","overall_status":"COMPLETED","enrollment_count":80,"lead_sponsor_name":"Medical University of Gdansk","has_results":false},{"nct_id":"NCT05422417","title":"Dorsomedial Prefrontal Neuromodulation in Treatment-resistant Depression","phase":"NA","overall_status":"UNKNOWN","enrollment_count":75,"lead_sponsor_name":"Taipei Veterans General Hospital, Taiwan","has_results":false},{"nct_id":"NCT07526454","title":"Electroconvulsive Therapy Versus Intravenous Ketamine in Treatment-Resistant Major Depressive Disorder","phase":"NA","overall_status":"COMPLETED","enrollment_count":70,"lead_sponsor_name":"Tanta University","has_results":false},{"nct_id":"NCT06399406","title":"Mindfulness Engaged Neurostimulation for Depression","phase":"PHASE2","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":70,"lead_sponsor_name":"University of California, San Diego","has_results":false},{"nct_id":"NCT05809609","title":"Glutamate Emotion Memory Study","phase":"NA","overall_status":"RECRUITING","enrollment_count":60,"lead_sponsor_name":"University of Oxford","has_results":false},{"nct_id":"NCT06783361","title":"Accelerated Transcranial Magnetic Stimulation in Treatment-Resistant Depressed Patients","phase":"NA","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":60,"lead_sponsor_name":"Ataturk University","has_results":false},{"nct_id":"NCT06511908","title":"Investigation of the Antidepressant Effects of (2R,6R)-HNK, an Enhancer of Synaptic Glutamate Release, in Treatment-Resistant Depression","phase":"PHASE2","overall_status":"RECRUITING","enrollment_count":50,"lead_sponsor_name":"National Institute of Mental Health (NIMH)","has_results":false},{"nct_id":"NCT03932825","title":"Nitrous Oxide for Major Depressive Disorder","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":44,"lead_sponsor_name":"Lingjiang Li","has_results":false},{"nct_id":"NCT04608396","title":"Mechanistic Evaluation of Response in TRD (MERIT)","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":44,"lead_sponsor_name":"Axsome Therapeutics, Inc.","has_results":false},{"nct_id":"NCT04957368","title":"Sustained Mood Improvement With Laughing Gas Exposure: A Randomized Controlled Pilot Trial","phase":"PHASE4","overall_status":"COMPLETED","enrollment_count":40,"lead_sponsor_name":"Unity Health Toronto","has_results":false},{"nct_id":"NCT02556606","title":"Ketamine for Treatment Resistant Late-Life Depression","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":33,"lead_sponsor_name":"VA Office of Research and Development","has_results":true},{"nct_id":"NCT04701866","title":"Music as an Intervention to Improve Hemodynamic Tolerability of Ketamine in Depression","phase":"NA","overall_status":"COMPLETED","enrollment_count":32,"lead_sponsor_name":"Douglas Mental Health University Institute","has_results":false},{"nct_id":"NCT07052058","title":"Triple-Blind Randomized Clinical Trial of Tocilizumab vs Placebo: Potential Use of an IL-6 Antagonist as an Adjuvant to Standard Treatment for Treatment-Resistant Major Depression in the Brazilian Public Health System (SUS)","phase":"PHASE2","overall_status":"NOT_YET_RECRUITING","enrollment_count":32,"lead_sponsor_name":"Hospital de Clinicas de Porto Alegre","has_results":false},{"nct_id":"NCT07422519","title":"Virtual Reality-Based Mindfulness as an Adjunct to Treatment as Usual in Treatment-Resistant Depression","phase":"NA","overall_status":"RECRUITING","enrollment_count":30,"lead_sponsor_name":"Hospital Universitari Vall d'Hebron Research Institute","has_results":false},{"nct_id":"NCT07097025","title":"2-Year Study of Vagus Nerve Stimulation for Higher-Grade Treatment-Resistant Depression: Clinical Outcomes and Policy Recommendation","phase":"","overall_status":"COMPLETED","enrollment_count":19,"lead_sponsor_name":"Dr.Yoav Domany","has_results":false},{"nct_id":"NCT04698603","title":"Clinical Study of GH001 in Depression","phase":"PHASE1, PHASE2","overall_status":"COMPLETED","enrollment_count":16,"lead_sponsor_name":"GH Research Ireland Limited","has_results":false},{"nct_id":"NCT07112261","title":"Avatar Therapy in Virtual Reality for Treatment-Resistant Major Depressive Disorder: A Pilot Study","phase":"NA","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":15,"lead_sponsor_name":"Ciusss de L'Est de l'Île de Montréal","has_results":false},{"nct_id":"NCT05615948","title":"Oral Aspirin + Ketamine as Adjunct to Oral Antidepressant Therapy for Depression","phase":"PHASE4","overall_status":"COMPLETED","enrollment_count":15,"lead_sponsor_name":"Maimonides Medical Center","has_results":false},{"nct_id":"NCT05045378","title":"Low-dose Ketamine Infusion Among Adolescents With Treatment-resistant Depression","phase":"PHASE4","overall_status":"COMPLETED","enrollment_count":12,"lead_sponsor_name":"Taipei Veterans General Hospital, Taiwan","has_results":false},{"nct_id":"NCT05196971","title":"A Study To Evaluate The Safety, Tolerability And Pharmacokinetics of HS-10345 In Treatment-Resistant Depression","phase":"PHASE1","overall_status":"COMPLETED","enrollment_count":12,"lead_sponsor_name":"Jiangsu Hansoh Pharmaceutical Co., Ltd.","has_results":false},{"nct_id":"NCT04727229","title":"Stellate Ganglion Block for Major Depressive Disorder.","phase":"PHASE4","overall_status":"COMPLETED","enrollment_count":10,"lead_sponsor_name":"Unity Health Toronto","has_results":false},{"nct_id":"NCT02882711","title":"The UTHealth Ketamine Project","phase":"PHASE2","overall_status":"TERMINATED","enrollment_count":10,"lead_sponsor_name":"The University of Texas Health Science Center, Houston","has_results":true},{"nct_id":"NCT03667872","title":"Efficacy and Safety of DBS in Patients With Treatment-Resistant Depression","phase":"NA","overall_status":"UNKNOWN","enrollment_count":6,"lead_sponsor_name":"Beijing Pins Medical Co., Ltd","has_results":false},{"nct_id":"NCT05323019","title":"Repeated Intranasal Esketamine Plus Almond Therapy in Patients With Treatment Resistant Depression","phase":"PHASE2","overall_status":"TERMINATED","enrollment_count":6,"lead_sponsor_name":"Zylorion Health","has_results":false},{"nct_id":"NCT06431386","title":"Behavioural Activation Therapy and Esketamine for Resistant Depression","phase":"NA","overall_status":"TERMINATED","enrollment_count":6,"lead_sponsor_name":"The Royal's Institute of Mental Health Research","has_results":false},{"nct_id":"NCT03360942","title":"Long Term Follow-up of Deep Brain Stimulation for Treatment-Resistant Depression","phase":"NA","overall_status":"TERMINATED","enrollment_count":5,"lead_sponsor_name":"Dartmouth-Hitchcock Medical Center","has_results":true},{"nct_id":"NCT06232291","title":"Observation of Safety and Tolerability Within 1 Year of the Use of R-ketamine / Placebo in Drug-resistant Depression","phase":"","overall_status":"COMPLETED","enrollment_count":3,"lead_sponsor_name":"Medical University of Gdansk","has_results":false},{"nct_id":"NCT06730841","title":"Dose-Optimized and Spaced Transcranial Direct Current Stimulation for Treatment-Resistant Depression","phase":"NA","overall_status":"COMPLETED","enrollment_count":3,"lead_sponsor_name":"University of California, San Diego","has_results":false},{"nct_id":"NCT03254017","title":"Remotely Programmed Deep Brain Stimulation of the Bilateral Habenula for Treatment- Resistant Major Depression: An Open Label Pilot Trial","phase":"NA","overall_status":"TERMINATED","enrollment_count":2,"lead_sponsor_name":"Ruijin Hospital","has_results":false},{"nct_id":"NCT02757521","title":"Nitrous TRD Bipolar Depression","phase":"EARLY_PHASE1","overall_status":"TERMINATED","enrollment_count":1,"lead_sponsor_name":"Washington University School of Medicine","has_results":true},{"nct_id":"NCT05438758","title":"Repeated Intranasal Esketamine Plus Almond Therapy in Participants With Treatment Resistant Depressive Disorder - 3 Month Extension Study","phase":"PHASE2","overall_status":"WITHDRAWN","enrollment_count":0,"lead_sponsor_name":"Zylorion Health","has_results":false},{"nct_id":"NCT05381974","title":"The Effects of Psilocybin on Self-Focus and Self-Related Processing in Treatment Resistant MDD","phase":"PHASE2","overall_status":"WITHDRAWN","enrollment_count":0,"lead_sponsor_name":"Massachusetts General Hospital","has_results":false}],"total":47},"guidelines":[],"source":"Drug Landscape verified database"}