{"disease":{"id":"treatment-of-moderate-to-severe-vasomotor-symptoms-associated-with-the-menopause","name":"Treatment of moderate to severe vasomotor symptoms associated with the menopause","therapeutic_area":"","data":{},"enrichment_level":0,"last_enriched_at":null,"visit_count":0,"created_at":"2026-04-19T18:31:21.150Z","updated_at":"2026-04-19T18:39:44.960Z","meddra_pt":null,"meddra_code":null,"icd10_codes":null,"synonyms":[],"prevalence_global":null,"prevalence_us":null,"marketed_drug_count":1,"pipeline_drug_count":0,"trial_count":0},"drugs":{"marketed":[{"drug_id":"menest","indication_name":"Treatment of moderate to severe vasomotor symptoms associated with the menopause","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Menest","generic_name":"Estrogens, Esterified","company_name":"Pfizer Inc.","drug_phase":"marketed","molecular_target":"Estrogen receptor","drug_class":"Estrogen","quality_score":10,"revenue":null,"mechanism":"Esterified estrogens, sold under the brand names Estratab and Menest, are used for hormone therapy and cancer treatment."}],"pipeline":[],"offLabel":[],"totalMarketed":1,"totalPipeline":0},"trials":{"data":[],"total":0},"guidelines":[{"drug_id":"menest","guideline_body":"FDA label","recommendation":"Estrogens, esterified (Menest) is indicated for the treatment of female hypogonadism.","line_of_therapy":"1L","evidence_grade":"B","guideline_year":null},{"drug_id":"menest","guideline_body":"FDA label","recommendation":"Estrogens, esterified (Menest) is indicated for the treatment of female castration.","line_of_therapy":"1L","evidence_grade":"B","guideline_year":null},{"drug_id":"menest","guideline_body":"FDA label","recommendation":"Estrogens, esterified (Menest) is indicated for the treatment of primary ovarian failure.","line_of_therapy":"1L","evidence_grade":"B","guideline_year":null},{"drug_id":"menest","guideline_body":"FDA label","recommendation":"Estrogens, esterified (Menest) is indicated for the palliation of breast cancer in appropriately selected women and men with metastatic disease.","line_of_therapy":"2L","evidence_grade":"B","guideline_year":null},{"drug_id":"menest","guideline_body":"FDA label","recommendation":"Estrogens, esterified (Menest) is indicated for the palliative therapy of advanced prostatic carcinoma.","line_of_therapy":"2L","evidence_grade":"B","guideline_year":null},{"drug_id":"menest","guideline_body":"FDA label","recommendation":"Estrogens, esterified (Menest) is indicated for the treatment of moderate to severe vasomotor symptoms associated with the menopause.","line_of_therapy":"1L","evidence_grade":"B","guideline_year":null},{"drug_id":"menest","guideline_body":"FDA label","recommendation":"Estrogens, esterified (Menest) is indicated for the treatment of moderate to severe symptoms of vulvar and vaginal atrophy associated with the menopause. Topical vaginal products should be considered when prescribing solely for these symptoms.","line_of_therapy":"1L","evidence_grade":"B","guideline_year":null}],"source":"Drug Landscape verified database"}