{"disease":{"id":"tobacco-use-disorder","name":"Tobacco Use Disorder","therapeutic_area":"","data":{},"enrichment_level":0,"last_enriched_at":null,"visit_count":0,"created_at":"2026-04-19T18:31:21.150Z","updated_at":"2026-04-19T18:31:21.551Z","meddra_pt":null,"meddra_code":null,"icd10_codes":null,"synonyms":[],"prevalence_global":null,"prevalence_us":null,"marketed_drug_count":0,"pipeline_drug_count":2,"trial_count":8},"drugs":{"marketed":[],"pipeline":[{"drug_id":"long-term-varenicline","indication_name":"Tobacco Use Disorder","indication_type":"pipeline","phase":"preclinical","line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Long-Term Varenicline","generic_name":"long-term-varenicline","company_name":"Pfizer Inc.","drug_phase":"preclinical","molecular_target":"","drug_class":"Varenicline tablet x 24 weeks","quality_score":null,"revenue":null,"mechanism":"Varenicline tablet x 24 weeks"},{"drug_id":"short-term-varenicline","indication_name":"Tobacco Use Disorder","indication_type":"pipeline","phase":"preclinical","line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Short-Term Varenicline","generic_name":"short-term-varenicline","company_name":"Pfizer Inc.","drug_phase":"preclinical","molecular_target":"","drug_class":"varenicline tablet for 12 weeks, followed by placebo tablet manufactured to mimic varenicline 1 mg t","quality_score":0,"revenue":null,"mechanism":"varenicline tablet for 12 weeks, followed by placebo tablet manufactured to mimic varenicline 1 mg t"}],"offLabel":[],"totalMarketed":0,"totalPipeline":2},"trials":{"data":[{"nct_id":"NCT02991534","title":"Cardiovascular Risk Screening and Risk Reduction in Women Vets","phase":"NA","overall_status":"COMPLETED","enrollment_count":6009,"lead_sponsor_name":"VA Office of Research and Development","has_results":true},{"nct_id":"NCT03194958","title":"Helping Poor Smokers Quit","phase":"NA","overall_status":"COMPLETED","enrollment_count":1944,"lead_sponsor_name":"Washington University School of Medicine","has_results":true},{"nct_id":"NCT05515354","title":"Smoking Cessation and Menstrual Cycle Phase","phase":"PHASE4","overall_status":"RECRUITING","enrollment_count":1200,"lead_sponsor_name":"Centre for Addiction and Mental Health","has_results":false},{"nct_id":"NCT02896400","title":"Optimizing Tobacco Dependence Treatment in the Emergency Department","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":1056,"lead_sponsor_name":"Yale University","has_results":true},{"nct_id":"NCT02146911","title":"The MATCH (Medication Aids for Tobacco Cessation and Health) Study","phase":"NA","overall_status":"COMPLETED","enrollment_count":968,"lead_sponsor_name":"Centre for Addiction and Mental Health","has_results":false},{"nct_id":"NCT02232737","title":"Project 3, Study 2: Extended Exposure to Low Nicotine Content Cigarettes in People With Current Affective Disorders","phase":"PHASE1, PHASE2","overall_status":"COMPLETED","enrollment_count":775,"lead_sponsor_name":"Brown University","has_results":true},{"nct_id":"NCT00507728","title":"Pharmacogenetics, Emotional Reactivity and Smoking","phase":"PHASE2, PHASE3","overall_status":"COMPLETED","enrollment_count":646,"lead_sponsor_name":"M.D. Anderson Cancer Center","has_results":true},{"nct_id":"NCT02271919","title":"Varenicline and Combined NRT for Smoking Cessation","phase":"PHASE4","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":631,"lead_sponsor_name":"M.D. Anderson Cancer Center","has_results":false},{"nct_id":"NCT02781090","title":"RCT of an Internet Cessation Program Plus Online Social Network for HIV+ Smokers","phase":"NA","overall_status":"COMPLETED","enrollment_count":512,"lead_sponsor_name":"Montefiore Medical Center","has_results":true},{"nct_id":"NCT06042361","title":"Enhancing Equity in Smoke-free Housing","phase":"NA","overall_status":"ENROLLING_BY_INVITATION","enrollment_count":480,"lead_sponsor_name":"Harvard School of Public Health (HSPH)","has_results":false},{"nct_id":"NCT01539525","title":"Screening to Augment Referral to Treatment- Project START","phase":"NA","overall_status":"COMPLETED","enrollment_count":439,"lead_sponsor_name":"Yale University","has_results":true},{"nct_id":"NCT03237949","title":"Text Messaging and Telephone Counseling for Supporting Post-discharge Quit Attempts","phase":"NA","overall_status":"COMPLETED","enrollment_count":400,"lead_sponsor_name":"Federal University of Juiz de Fora","has_results":false},{"nct_id":"NCT06966362","title":"Varenicline for Smoking Reduction in Veterans Not Ready To Quit","phase":"PHASE4","overall_status":"NOT_YET_RECRUITING","enrollment_count":400,"lead_sponsor_name":"VA Office of Research and Development","has_results":false},{"nct_id":"NCT04417595","title":"Omega-3 Fatty Acids for Smoking Cessation in Pregnancy","phase":"PHASE2","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":400,"lead_sponsor_name":"Vanderbilt University Medical Center","has_results":false},{"nct_id":"NCT07123389","title":"Family and Peer Influences on Nicotine Dependence in Medical Students of South Punjab","phase":"","overall_status":"COMPLETED","enrollment_count":366,"lead_sponsor_name":"Nishtar Medical University","has_results":false},{"nct_id":"NCT06239350","title":"Young Adult Tobacco/Nicotine and Cannabis Co-use","phase":"NA","overall_status":"RECRUITING","enrollment_count":350,"lead_sponsor_name":"Medical University of South Carolina","has_results":false},{"nct_id":"NCT05030272","title":"Comparing Two Behavioral Approaches to Quitting Smoking in Mental Health Settings","phase":"NA","overall_status":"COMPLETED","enrollment_count":343,"lead_sponsor_name":"Wake Forest University Health Sciences","has_results":false},{"nct_id":"NCT04498988","title":"Volitional Dysfunction in Self-control Failures and Addictive Behaviors","phase":"","overall_status":"COMPLETED","enrollment_count":338,"lead_sponsor_name":"Technische Universität Dresden","has_results":false},{"nct_id":"NCT00542373","title":"Widefield Fluorescence and Reflectance Imaging Systems and Oral Tissue Samples in Monitoring Participants at Risk for Developing Oral Cancer","phase":"NA","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":338,"lead_sponsor_name":"M.D. Anderson Cancer Center","has_results":false},{"nct_id":"NCT04092101","title":"Low Nicotine Content Cigarettes in Vulnerable Populations: Opioid Use Disorder","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":326,"lead_sponsor_name":"University of Vermont","has_results":true},{"nct_id":"NCT04090879","title":"Low Nicotine Content Cigarettes in Vulnerable Populations: Affective Disorders","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":326,"lead_sponsor_name":"Brown University","has_results":true},{"nct_id":"NCT04092387","title":"Low Nicotine Content Cigarettes in Vulnerable Populations: Women of Reproductive Age","phase":"NA","overall_status":"COMPLETED","enrollment_count":326,"lead_sponsor_name":"University of Vermont","has_results":true},{"nct_id":"NCT06614504","title":"Nicotine Regulation for Dual Users of E-cigarettes and Cigarettes","phase":"PHASE2","overall_status":"RECRUITING","enrollment_count":308,"lead_sponsor_name":"University of Vermont","has_results":false},{"nct_id":"NCT05110872","title":"Cigarette and E-cigarette Flavors Manipulations in the Experimental Tobacco Marketplace","phase":"NA","overall_status":"COMPLETED","enrollment_count":302,"lead_sponsor_name":"Virginia Polytechnic Institute and State University","has_results":true},{"nct_id":"NCT06790342","title":"Optimizing Treatment of Co-occurring Smoking and Unhealthy Alcohol Use Among PWH in Nairobi, Kenya","phase":"PHASE3","overall_status":"NOT_YET_RECRUITING","enrollment_count":300,"lead_sponsor_name":"University of Chicago","has_results":false},{"nct_id":"NCT01771627","title":"Varenicline or Nicotine Patch in Promoting Smoking Cessation Among Current Smokers","phase":"NA","overall_status":"COMPLETED","enrollment_count":300,"lead_sponsor_name":"Roswell Park Cancer Institute","has_results":true},{"nct_id":"NCT03365362","title":"A Trial of Directly Observed and Long-term Varenicline","phase":"PHASE4","overall_status":"COMPLETED","enrollment_count":243,"lead_sponsor_name":"Albert Einstein College of Medicine","has_results":false},{"nct_id":"NCT06922617","title":"STEPS: Substance Use Trial of E-cigarettes or Pharmacotherapy for Smoking","phase":"NA","overall_status":"RECRUITING","enrollment_count":240,"lead_sponsor_name":"Medical University of South Carolina","has_results":false},{"nct_id":"NCT07474623","title":"Effects of Nicotine Dependence on Multidimensional Health Outcomes","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":212,"lead_sponsor_name":"Izmir Democracy University","has_results":false},{"nct_id":"NCT03000387","title":"Personalized Dosing of Nicotine Replacement (NRT to Effect)","phase":"PHASE4","overall_status":"COMPLETED","enrollment_count":211,"lead_sponsor_name":"Centre for Addiction and Mental Health","has_results":false},{"nct_id":"NCT03948893","title":"Smoking Cessation Behavioral Treatment Study","phase":"NA","overall_status":"RECRUITING","enrollment_count":200,"lead_sponsor_name":"University of Missouri-Columbia","has_results":false},{"nct_id":"NCT06883162","title":"Cannabis-Tobacco Co-Use Treatment Study","phase":"PHASE3","overall_status":"RECRUITING","enrollment_count":200,"lead_sponsor_name":"Medical University of South Carolina","has_results":false},{"nct_id":"NCT05766553","title":"Effects of Mindfulness Meditation in Virtual Reality on Craving and Smoking Cessation","phase":"NA","overall_status":"RECRUITING","enrollment_count":200,"lead_sponsor_name":"Centre Hospitalier Henri Laborit","has_results":false},{"nct_id":"NCT07366294","title":"Lemongrass (Cymbopogon Citratus) on Nicotine Dependence, Cotinine Levels, and Related Biomarkers in Adult Smokers","phase":"NA","overall_status":"COMPLETED","enrollment_count":200,"lead_sponsor_name":"Titin Andri Wihastuti","has_results":false},{"nct_id":"NCT04228965","title":"Cannabis and Tobacco Co-use Study","phase":"PHASE4","overall_status":"COMPLETED","enrollment_count":181,"lead_sponsor_name":"Medical University of South Carolina","has_results":true},{"nct_id":"NCT03163056","title":"Smoking Cessation Treatment for Depressed Smokers","phase":"NA","overall_status":"COMPLETED","enrollment_count":180,"lead_sponsor_name":"University of Oviedo","has_results":false},{"nct_id":"NCT03553992","title":"An Extended Facebook Intervention for Young Sexual and Gender Minority Smokers","phase":"NA","overall_status":"COMPLETED","enrollment_count":173,"lead_sponsor_name":"University of California, San Francisco","has_results":false},{"nct_id":"NCT07501624","title":"Engaging Pharmacists to Advance Tobacco Treatment Service Delivery","phase":"NA","overall_status":"ENROLLING_BY_INVITATION","enrollment_count":172,"lead_sponsor_name":"Medical University of South Carolina","has_results":false},{"nct_id":"NCT03259360","title":"A Facebook Intervention for Young Sexual and Gender Minority Smokers","phase":"NA","overall_status":"COMPLETED","enrollment_count":165,"lead_sponsor_name":"University of California, San Francisco","has_results":false},{"nct_id":"NCT06798324","title":"tDCS Plus Varenicline for Smoking Cessation","phase":"PHASE4","overall_status":"RECRUITING","enrollment_count":160,"lead_sponsor_name":"Centre for Addiction and Mental Health","has_results":false},{"nct_id":"NCT03694327","title":"Innovative Digital Therapeutic for Smoking Cessation","phase":"NA","overall_status":"COMPLETED","enrollment_count":158,"lead_sponsor_name":"My Digital Study","has_results":true},{"nct_id":"NCT05045326","title":"Effectiveness of a Smoking Cessation Intervention in a Mental Health Day Hospital","phase":"NA","overall_status":"UNKNOWN","enrollment_count":150,"lead_sponsor_name":"Hospital Clinic of Barcelona","has_results":false},{"nct_id":"NCT05947162","title":"Effect of Orexin System on Nicotine Addiction and Its Neural Mechanism","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":150,"lead_sponsor_name":"Shenzhen Kangning Hospital","has_results":false},{"nct_id":"NCT02439255","title":"Effect of Black Raspberry Phytochemicals on Oral Microbiome in Current Smokers and Non-smokers","phase":"NA","overall_status":"COMPLETED","enrollment_count":148,"lead_sponsor_name":"Ohio State University Comprehensive Cancer Center","has_results":false},{"nct_id":"NCT04768114","title":"Implementation of Genomics in Substance Use Disorder Treatment","phase":"NA","overall_status":"COMPLETED","enrollment_count":148,"lead_sponsor_name":"Washington University School of Medicine","has_results":true},{"nct_id":"NCT01434342","title":"Feasibility of Delivering a Quitline Based Smoking Cessation Intervention in Cancer Patients","phase":"EARLY_PHASE1","overall_status":"COMPLETED","enrollment_count":146,"lead_sponsor_name":"Wake Forest University Health Sciences","has_results":true},{"nct_id":"NCT07104006","title":"Smoking Cessation Intervention for Young Adults Using MTM: A Randomized Controlled Trial","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":144,"lead_sponsor_name":"University of Nevada, Las Vegas","has_results":false},{"nct_id":"NCT02596685","title":"Effects of Electronic Cigarette Use on the Lungs","phase":"NA","overall_status":"COMPLETED","enrollment_count":142,"lead_sponsor_name":"Ohio State University Comprehensive Cancer Center","has_results":false},{"nct_id":"NCT05726045","title":"Increasing Smoking Cessation Success Through Sleep-amplified Memory Consolidation","phase":"NA","overall_status":"RECRUITING","enrollment_count":140,"lead_sponsor_name":"Central Institute of Mental Health, Mannheim","has_results":false},{"nct_id":"NCT02245308","title":"Abstinence Reinforcement Therapy (ART) for Homeless Veteran Smokers","phase":"PHASE4","overall_status":"COMPLETED","enrollment_count":133,"lead_sponsor_name":"VA Office of Research and Development","has_results":true}],"total":50},"guidelines":[],"source":"Drug Landscape verified database"}