{"disease":{"id":"thyroid-dysfunction","name":"thyroid dysfunction"},"drugs":{"marketed":[{"drug_id":"levothyroxine-sodium","indication_name":"Diagnostic Test for Thyroid Dysfunction","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Unithroid","generic_name":"LEVOTHYROXINE SODIUM","company_name":"Fresenius Kabi","drug_phase":"marketed","molecular_target":"Thyroid hormone receptor beta","drug_class":"l-Thyroxine","quality_score":70,"revenue":null,"mechanism":"Unithroid works by replacing or supplementing the thyroid hormone thyroxine, which is produced by the thyroid gland."},{"drug_id":"liothyronine","indication_name":"Diagnostic Test for Thyroid Dysfunction","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Triostat","generic_name":"LIOTHYRONINE","company_name":"Pfizer","drug_phase":"marketed","molecular_target":"Thyroid hormone receptor alpha","drug_class":"l-Triiodothyronine","quality_score":57,"revenue":null,"mechanism":"Triostat works by mimicking the natural thyroid hormone, l-Triiodothyronine, to stimulate the thyroid hormone receptor alpha."},{"drug_id":"protirelin","indication_name":"Diagnostic Test for Thyroid Dysfunction","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Lopremone","generic_name":"PROTIRELIN","company_name":"","drug_phase":"marketed","molecular_target":"Thyrotropin-releasing hormone receptor","drug_class":"protirelin","quality_score":10,"revenue":null,"mechanism":""},{"drug_id":"levothyroxin","indication_name":"Diagnostic Test for Thyroid Dysfunction","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"levothyroxin","company_name":"Ain Shams University","drug_phase":"marketed","molecular_target":"THAP domain-containing protein 1, Macrophage migration inhibitory factor, Malate dehydrogenase, mitochondrial","drug_class":"","quality_score":19,"revenue":null,"mechanism":null},{"drug_id":"thyroxine","indication_name":"Diagnostic Test for Thyroid Dysfunction","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Thyroxine","company_name":"Cancer Institute and Hospital, Chinese Academy of Medical Sciences","drug_phase":"marketed","molecular_target":"THAP domain-containing protein 1, Macrophage migration inhibitory factor, Malate dehydrogenase, mitochondrial","drug_class":"","quality_score":19,"revenue":null,"mechanism":null},{"drug_id":"levothyroxine","indication_name":"Diagnostic Test for Thyroid Dysfunction","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Synthroid","generic_name":"levothyroxine","company_name":"Generic (originally multiple — AbbVie/Synthroid)","drug_phase":"marketed","molecular_target":"THAP domain-containing protein 1, Macrophage migration inhibitory factor, Malate dehydrogenase, mitochondrial","drug_class":"Thyroid hormone","quality_score":10,"revenue":null,"mechanism":"Synthetic thyroxine (T4) that replaces deficient thyroid hormone, restoring normal metabolism, growth, and development."},{"drug_id":"triiodothyronine","indication_name":"Diagnostic Test for Thyroid Dysfunction","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Triiodothyronine","company_name":"Northwell Health","drug_phase":"marketed","molecular_target":"THAP domain-containing protein 1, Cytochrome P450 2C9, Proliferating cell nuclear antigen","drug_class":"","quality_score":null,"revenue":null,"mechanism":null}],"pipeline":[],"offLabel":[],"totalMarketed":7,"totalPipeline":0},"trials":{"data":[{"nct_id":"NCT05687474","title":"Baby Detect : Genomic Newborn Screening","phase":"","overall_status":"COMPLETED","enrollment_count":6824,"lead_sponsor_name":"Centre Hospitalier Universitaire de Liege","has_results":false},{"nct_id":"NCT04565873","title":"Thyroid Stimulating Hormone (TSH) Level Variations in Early Pregnancy","phase":"","overall_status":"COMPLETED","enrollment_count":1527,"lead_sponsor_name":"University of Jordan","has_results":false},{"nct_id":"NCT04019509","title":"The Influence of Different Thyroid Autoantibodies on Thyroid Function and Pregnancy Outcome After Assisted Reproductive Technology","phase":"NA","overall_status":"UNKNOWN","enrollment_count":900,"lead_sponsor_name":"Universitair Ziekenhuis Brussel","has_results":false},{"nct_id":"NCT06980064","title":"Wearable Devices Assist in the Detection, Screening, and Management of Major Diseases in Middle-aged and Elderly Populations","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":800,"lead_sponsor_name":"Tongji Hospital","has_results":false},{"nct_id":"NCT07428057","title":"Postoperative Hypocalcemia After Thyroidectomy","phase":"","overall_status":"RECRUITING","enrollment_count":600,"lead_sponsor_name":"Minia University","has_results":false},{"nct_id":"NCT04860622","title":"Normal Range of TSH and FT4 in Pregnancy","phase":"","overall_status":"COMPLETED","enrollment_count":528,"lead_sponsor_name":"Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research Hospital","has_results":false},{"nct_id":"NCT06169735","title":"Does Fluorescence With or Without Indocyanine Green Improve Parathyroid Identification and Preservation","phase":"PHASE4","overall_status":"RECRUITING","enrollment_count":417,"lead_sponsor_name":"University of Alabama at Birmingham","has_results":false},{"nct_id":"NCT04346992","title":"Prevalence Of Keratoconus Among Patients With Thyroid Gland Dysfunction","phase":"","overall_status":"COMPLETED","enrollment_count":400,"lead_sponsor_name":"Fayoum University","has_results":false},{"nct_id":"NCT04439747","title":"Develop and Implement Methods for Diagnostic and Treatment of Hormonal Disorders in Patients With Chronic Kidney Disease","phase":"","overall_status":"UNKNOWN","enrollment_count":400,"lead_sponsor_name":"Belarusian State Medical University","has_results":false},{"nct_id":"NCT03754621","title":"Upper Limit for TSH of First and Second Trimester Pregnancy in Turkey","phase":"","overall_status":"UNKNOWN","enrollment_count":400,"lead_sponsor_name":"Bartin State Hospital","has_results":false},{"nct_id":"NCT05786846","title":"Serum Thyroid Function After Iodinated Contrast Administration","phase":"","overall_status":"UNKNOWN","enrollment_count":400,"lead_sponsor_name":"Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University","has_results":false},{"nct_id":"NCT07272213","title":"Thyroid-Stimulating Hormone Levels in Pregnancy and Their Association With Depression, Anxiety, and Sexual Function","phase":"","overall_status":"RECRUITING","enrollment_count":180,"lead_sponsor_name":"Gaziosmanpasa Research and Education Hospital","has_results":false},{"nct_id":"NCT06293534","title":"Thyroid Dysfunction in Patients With Major Psychiatric Disorders","phase":"","overall_status":"UNKNOWN","enrollment_count":173,"lead_sponsor_name":"Assiut University","has_results":false},{"nct_id":"NCT06765941","title":"PTeye vs Surgeons Eyes in Intraoperative Identification and Functional Preservation of Parathyroid Glands During Thyroid Surgery: A Parallel Randomized Controlled Clinical Trial.","phase":"NA","overall_status":"RECRUITING","enrollment_count":154,"lead_sponsor_name":"Marcin Barczynski","has_results":false},{"nct_id":"NCT06739330","title":"Thyroid Dysfunction and Its Association With Metabolic Dysfunction-Associated Fatty Liver Disease","phase":"","overall_status":"RECRUITING","enrollment_count":150,"lead_sponsor_name":"Tanta University","has_results":false},{"nct_id":"NCT04470440","title":"Thyroid Dysfunction and Nivolumab Reponse in NSCLC","phase":"","overall_status":"COMPLETED","enrollment_count":134,"lead_sponsor_name":"University Hospital, Brest","has_results":false},{"nct_id":"NCT04160637","title":"Is There Benefit From Early Postoperative PTH Monitoring?","phase":"","overall_status":"UNKNOWN","enrollment_count":120,"lead_sponsor_name":"University Hospital Sestre Milosrdnice","has_results":false},{"nct_id":"NCT06272721","title":"Hypothyroidism in Pregnancy and Neuropsychological Development in Children","phase":"NA","overall_status":"UNKNOWN","enrollment_count":104,"lead_sponsor_name":"Fondazione Policlinico Universitario Agostino Gemelli IRCCS","has_results":false},{"nct_id":"NCT04613323","title":"Management of Thyroid Function in Hashimoto's Thyroiditis During Pregnancy","phase":"","overall_status":"UNKNOWN","enrollment_count":100,"lead_sponsor_name":"Centro Diagnostico Priamar","has_results":false},{"nct_id":"NCT04323007","title":"Thyroid Dysfunction in Patients With Nephrotic Syndrome","phase":"NA","overall_status":"UNKNOWN","enrollment_count":100,"lead_sponsor_name":"Merna Makram","has_results":false},{"nct_id":"NCT04304573","title":"Is Correcting Total Serum Calcium Levels Important After Thyroidectomy","phase":"","overall_status":"UNKNOWN","enrollment_count":100,"lead_sponsor_name":"University Hospital Sestre Milosrdnice","has_results":false},{"nct_id":"NCT07157267","title":"Evaluation of Thyroid Function, Lipid Profile, and Uric Acid Levels in Hemodialysis Patients","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":100,"lead_sponsor_name":"Assiut University","has_results":false},{"nct_id":"NCT05385029","title":"Fetal and Neonatal Thyroid in Pregnancies With Severe Acute Respiratory Syndrome Coronavirus 2 ( SARS- COV2 ) COVID-19","phase":"","overall_status":"COMPLETED","enrollment_count":95,"lead_sponsor_name":"OMER B ABDELBASIT","has_results":false},{"nct_id":"NCT06185309","title":"Evaluation of Different Psychiatric Symptoms in Patients With Thyroid Dysfunction","phase":"","overall_status":"UNKNOWN","enrollment_count":85,"lead_sponsor_name":"Assiut University","has_results":false},{"nct_id":"NCT05152927","title":"Near Infrared Autofluorescence (NIRAF) Detection for Identifying Parathyroid Glands During Parathyroidectomy","phase":"NA","overall_status":"COMPLETED","enrollment_count":79,"lead_sponsor_name":"University of California, San Francisco","has_results":true},{"nct_id":"NCT00504218","title":"Detection and Treatment of Endocrine Abnormalities in Childhood Cancer Survivors and Hematopoietic Stem Cell Transplant Recipients","phase":"","overall_status":"TERMINATED","enrollment_count":62,"lead_sponsor_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)","has_results":false},{"nct_id":"NCT06499142","title":"STP.168 Clinical Study Protocol Parakeet","phase":"NA","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":60,"lead_sponsor_name":"Neurovision Medical Products Inc","has_results":false},{"nct_id":"NCT04013308","title":"Iontophoresis With Potassium Iodide and Thyroid Function","phase":"NA","overall_status":"COMPLETED","enrollment_count":56,"lead_sponsor_name":"University of Rzeszow","has_results":false},{"nct_id":"NCT04658524","title":"Evaluation of Thyroid Function in Patients With Chronic Kidney Disease","phase":"","overall_status":"UNKNOWN","enrollment_count":44,"lead_sponsor_name":"Rio de Janeiro State University","has_results":false},{"nct_id":"NCT06187480","title":"Changes in Cardiac Functions in Patients Treated With Parathyroidectomy for Secondary Hyperparathyroidism","phase":"","overall_status":"COMPLETED","enrollment_count":37,"lead_sponsor_name":"Mersin University","has_results":false},{"nct_id":"NCT03787303","title":"Study of Euthyroid Hypothyroxinemia in Metastatic Breast Carcinoma","phase":"PHASE2","overall_status":"TERMINATED","enrollment_count":7,"lead_sponsor_name":"Aultman Health Foundation","has_results":true},{"nct_id":"NCT05980923","title":"Thyroid Profiles in Patients With Acute Illness","phase":"","overall_status":"WITHDRAWN","enrollment_count":0,"lead_sponsor_name":"Jordan Collaborating Cardiology Group","has_results":false}],"total":32},"guidelines":[],"source":"Drug Landscape verified database"}