{"disease":{"id":"thyroid-cancer","name":"Thyroid Cancer","therapeutic_area":"Oncology","data":{"aiSummary":"The treatment landscape for thyroid cancer is evolving, with surgery and radioactive iodine therapy remaining cornerstones for differentiated thyroid cancer. Targeted therapies, such as lenvatinib and vandetanib, have improved outcomes in advanced or metastatic disease. Recent advances include the development of highly selective RET inhibitors like selpercatinib and pralsetinib, offering improved efficacy and tolerability for RET-altered cancers. Ongoing research focuses on refining treatment strategies, including the use of immunotherapy and novel targeted agents, to improve outcomes across all subtypes.","drug_count":5,"description":"Thyroid cancer is a malignancy that originates in the thyroid gland, a butterfly-shaped organ in the neck. The most common type is papillary thyroid cancer, followed by follicular thyroid cancer, medullary thyroid cancer, and anaplastic thyroid cancer. Treatment approaches vary based on the cancer type and stage, often involving surgery, radioactive iodine therapy, and targeted therapies.","subtype_count":11},"enrichment_level":2,"last_enriched_at":null,"visit_count":0,"created_at":"2026-03-25T12:16:34.968Z","updated_at":"2026-03-25T12:16:34.968Z","meddra_pt":null,"meddra_code":null,"icd10_codes":null,"synonyms":[],"prevalence_global":null,"prevalence_us":null,"marketed_drug_count":0,"pipeline_drug_count":0,"trial_count":0},"drugs":{"marketed":[{"drug_id":"cabometyx","indication_name":"Progressive, Metastatic Medullary Thyroid Cancer","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Cometriq","generic_name":"Cabometyx","company_name":"Exelixis","drug_phase":"marketed","molecular_target":"Vascular endothelial growth factor receptor 2","drug_class":"Kinase 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Cancer","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Cometriq","generic_name":"CABOZANTINIB","company_name":"Exelixis Inc","drug_phase":"marketed","molecular_target":"Vascular endothelial growth factor receptor 2","drug_class":"Kinase Inhibitor","quality_score":53,"revenue":null,"mechanism":"Cometriq works by blocking the activity of vascular endothelial growth factor receptor 2, a protein involved in tumor growth and angiogenesis."},{"drug_id":"pf-07059013","indication_name":"Treatment of certain types of thyroid cancer","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Pf-07059013","generic_name":"pf-07059013","company_name":"Pfizer","drug_phase":"marketed","molecular_target":"Unknown","drug_class":"Unknown","quality_score":25,"revenue":null,"mechanism":""},{"drug_id":"levoxyl","indication_name":"TSH suppression in thyrotropin-dependent well-differentiated thyroid cancer - adjunct to surgery","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Levoxyl","generic_name":"Levothyroxine Sodium","company_name":"Pfizer Inc.","drug_phase":"marketed","molecular_target":"Thyroid receptor proteins attached to DNA","drug_class":"Thyroid hormone replacement","quality_score":76,"revenue":null,"mechanism":"Levothyroxine binds thyroid receptors in cell nuclei to activate gene transcription and protein synthesis."},{"drug_id":"levoxyl","indication_name":"TSH suppression in thyrotropin-dependent well-differentiated thyroid cancer - adjunct to radioiodine therapy","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Levoxyl","generic_name":"Levothyroxine Sodium","company_name":"Pfizer Inc.","drug_phase":"marketed","molecular_target":"Thyroid receptor proteins attached to DNA","drug_class":"Thyroid hormone replacement","quality_score":76,"revenue":null,"mechanism":"Levothyroxine binds thyroid receptors in cell nuclei to activate gene transcription and protein synthesis."},{"drug_id":"trametinib","indication_name":"Locally advanced or metastatic anaplastic thyroid cancer (ATC) with BRAF V600E 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